Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases

Molecular Cell

Volumn 6, Issue 5, 2000, Pages 1195-1205

  Yan, Yuan ^a   Barlev, Nickolai A ^a   Haley, Randall H ^a   Berger, Shelley L ^a   Marmorstein, Ronen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COENZYME A; HISTONE ACETYLTRANSFERASE; HISTONE H1;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; YEAST;

EID: 0033635283     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00116-7     Document Type: Article

References (58)

1. Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila
2. NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p
3. The CBP co-activator is a histone acetyltransferase
4. Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs
5. The translocation t(8;16)(p11, p13) of acute myeloid leukemia fuses a putative acetyltransferase to the CREB binding protein
6. Slow-cooling protocols for crystallographic refinement by simulated annealing
7. Crystallographic R factor refinement by molecular dynamics
8. Crystallography and NMR system: A new software suite for macromolecular structure determination
9. Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)
10. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein
11. Esa1p is an essential histone acetyltransferase required for cell cycle progression
12. Crystal structure of the histone acetyltransferase domain of the human P/CAF transcriptional regulator bound to coenzyme-A
13. Structure of the histone acetyltransferase Hat1: A paradigm for the GCN5-related N-acetyltransferase superfamily
14. Purification and characterization of the cytoplasmic histone acetyltransferase B of maize embryos
15. Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription
16. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
17. The SAGA unfolds: Convergence of transcription regulators in chromatin-modifying complexes
18. The structural basis of ordered substrate binding by serotonin N-acetyltransferase: Enzyme complex at 1.8 A resolution with a bisubstrate analog
19. Melatonin biosynthesis: The structure of serotonin N-acetyltransferase at 2.5 angstrom resolution suggests a catalytic mechanism
20. mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
21. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein
22. Protein hydration observed by X-ray diffraction: Solvation properties of penicillopepsin and neuraminidase crystal structures
23. The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)- FACT complex
24. A graphics model building and refinement system for macromolecules
25. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 tat transactivator
26. ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation
27. Identification of a gene encoding a yeast histone H4 acetyltransferase
28. Substrate and sequential site specificity of cytoplasmic histone acetyltransferases of maize and rat liver
29. Roles of histone acetyltransferases and deacetylases in gene regulation
30. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
31. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
32. Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14
33. The TAF(II)230/250 subunit of TFIID has histone acetyltransferase activity
34. A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF
35. GCN5-related histone N-acetyltransferases belong to a diverse superfamily that include the yeast SPT10 protein
36. Oscillation data reduction program
37. The major cytoplasmic histone acetyltransferase in yeast: Links to chromatin replication and histone metabolism
38. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases
39. Torsion angle dynamics: Reduced variable conformational sampling enhances crystallographic structure refinement
40. Structure of the Tetrahymena GCN5 bound to coenzyme-A and a histone H3 peptide
41. HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4
42. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates
43. Zinc mining for protein domains
44. The p300/CBP family: Integrating signals with transcription factors and chromatin
45. ESA1 is a histone acetyltransferase that is essential for growth in yeast
46. The Drosophila MSL complex acetylates histone h4 at lysine 16, a chromatin modification linked to dosage compensation
47. Acetylation of histones and transcription-related factors
48. Sas3 is a histone acetyltransferase and requires a zinc finger motif
49. Catalytic mechanism and function of invariant glutamic acid-173 from the histone acetyltransferase GCN5 transcriptional coactivator
50. Automated MAD and MIR structure solution
51. Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator
52. Application of a novel fluorescence histone acetyltransferase enzyme assay to study the substrate specificity of human PCAF
53. Nucleosomal DNA regulates the core-histone-binding subunit of the human HAT1 acetyltransferase
54. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
55. Crystal structure of the anti-fungal target N-myristoyltransferase
56. Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase
57. Crystal structure of an aminoglcoside 6'-N-acetyltransferase: Defining the GCN5-related N-acetyltransferase superfamily fold