메뉴 건너뛰기




Volumn 13, Issue 10, 1999, Pages 1525-1533

The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator

Author keywords

ENL; Leukemia; MLL ALL1 HRX; t(11; 19); Transcription; Translocation

Indexed keywords

TRANSCRIPTION FACTOR;

EID: 0344466803     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401534     Document Type: Article
Times cited : (37)

References (44)
  • 1
    • 0025910286 scopus 로고
    • Oncogenic conversion of transcription factors by chromosomal translocations
    • Cleary ML. Oncogenic conversion of transcription factors by chromosomal translocations. Cell 1991; 66: 619-622.
    • (1991) Cell , vol.66 , pp. 619-622
    • Cleary, M.L.1
  • 2
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look TA. Oncogenic transcription factors in the human acute leukemias. Science 1997; 278: 1059-1064.
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, T.A.1
  • 3
    • 0025984266 scopus 로고
    • Translocations, master genes, and differences between the origins of acute and chronic leukemias
    • Rabbitts TH. Translocations, master genes, and differences between the origins of acute and chronic leukemias. Cell 1991; 67: 641-644.
    • (1991) Cell , vol.67 , pp. 641-644
    • Rabbitts, T.H.1
  • 4
    • 0027219166 scopus 로고
    • Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia
    • Felix CA, Winick NJ, Negrini M, Bowman WP, Croce CM, Lange BJ. Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia. Cancer Res 1993; 53: 2954-2956.
    • (1993) Cancer Res , vol.53 , pp. 2954-2956
    • Felix, C.A.1    Winick, N.J.2    Negrini, M.3    Bowman, W.P.4    Croce, C.M.5    Lange, B.J.6
  • 6
    • 0029018546 scopus 로고
    • Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations
    • Bernard OA, Berger R. Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. Genes Chromos Cancer 1995; 13: 75-85.
    • (1995) Genes Chromos Cancer , vol.13 , pp. 75-85
    • Bernard, O.A.1    Berger, R.2
  • 7
    • 0030941513 scopus 로고    scopus 로고
    • Disruption of a homolog of trithorax by 11q23 translocations: Leukemogenic and transcriptional implications
    • Waring PM, Cleary ML. Disruption of a homolog of trithorax by 11q23 translocations: leukemogenic and transcriptional implications. Curr Top Microbiol Immunol 1997; 220: 1-23.
    • (1997) Curr Top Microbiol Immunol , vol.220 , pp. 1-23
    • Waring, P.M.1    Cleary, M.L.2
  • 8
    • 0026936328 scopus 로고
    • A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukemia
    • Djabali M, Selleri L, Parry P, Bower M, Young BD, Evans GA. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukemia. Nat Genet 1992; 2: 113-118.
    • (1992) Nat Genet , vol.2 , pp. 113-118
    • Djabali, M.1    Selleri, L.2    Parry, P.3    Bower, M.4    Young, B.D.5    Evans, G.A.6
  • 9
    • 0026496887 scopus 로고
    • The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
    • Gu Y, Nakamura T, Alder H, Pasad R, Canaani O, Cimino G, Croce CM, Canaani E. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 1992; 71: 701-708.
    • (1992) Cell , vol.71 , pp. 701-708
    • Gu, Y.1    Nakamura, T.2    Alder, H.3    Pasad, R.4    Canaani, O.5    Cimino, G.6    Croce, C.M.7    Canaani, E.8
  • 10
    • 0026454451 scopus 로고
    • Disruption of a homolog of trithorax by 11q23 translocations in acute leukemias
    • Tkachuk DC, Kohler S, Cleary ML. Disruption of a homolog of trithorax by 11q23 translocations in acute leukemias. Cell 1992; 71: 691-700.
    • (1992) Cell , vol.71 , pp. 691-700
    • Tkachuk, D.C.1    Kohler, S.2    Cleary, M.L.3
  • 12
    • 0028869112 scopus 로고
    • Altered HOX expression and segmental identity in MLL-mutant mice
    • Yu BD, Hess JL, Horning SE, Brown GA, Korsmeyer SJ. Altered HOX expression and segmental identity in MLL-mutant mice. Nature 1995; 378: 505-508.
    • (1995) Nature , vol.378 , pp. 505-508
    • Yu, B.D.1    Hess, J.L.2    Horning, S.E.3    Brown, G.A.4    Korsmeyer, S.J.5
  • 13
    • 0032168459 scopus 로고    scopus 로고
    • Mll, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
    • Yu BD, Hanson RD, Hess JL, Horning SE, Korsmeyer SJ. MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci USA 1998; 95: 10632-10636.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10632-10636
    • Yu, B.D.1    Hanson, R.D.2    Hess, J.L.3    Horning, S.E.4    Korsmeyer, S.J.5
  • 14
    • 0032126677 scopus 로고    scopus 로고
    • Growth disturbance in fetal liver hematopoiesis of MLL-mutant mice
    • Yagi H, Deguchi K, Aono A, Tani Y, Kishimoto T, Komori T. Growth disturbance in fetal liver hematopoiesis of MLL-mutant mice. Blood 1998; 92: 108-117.
    • (1998) Blood , vol.92 , pp. 108-117
    • Yagi, H.1    Deguchi, K.2    Aono, A.3    Tani, Y.4    Kishimoto, T.5    Komori, T.6
  • 15
    • 0030791974 scopus 로고    scopus 로고
    • Immortalization and leukemic transformation of a myelomonocytic precursor by retro-virally transduced HRX-ENL
    • Lavau C, Szilvassy SJ, Slany R, Cleary ML. Immortalization and leukemic transformation of a myelomonocytic precursor by retro-virally transduced HRX-ENL. EMBO J 1997; 16: 4226-4237.
    • (1997) EMBO J , vol.16 , pp. 4226-4237
    • Lavau, C.1    Szilvassy, S.J.2    Slany, R.3    Cleary, M.L.4
  • 16
    • 0031972784 scopus 로고    scopus 로고
    • The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX
    • Slany RK, Lavau C, Cleary ML. The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Mol Cell Biol 1998; 18: 122-129.
    • (1998) Mol Cell Biol , vol.18 , pp. 122-129
    • Slany, R.K.1    Lavau, C.2    Cleary, M.L.3
  • 19
    • 0028091804 scopus 로고
    • 11q23 translocations split the 'AT-hook' cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene
    • Zeleznik-Le NJ, Harden AM, Rowley JD. 11q23 translocations split the 'AT-hook' cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene. Proc Natl Acad Sci USA 1994; 91: 10610-10614.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10610-10614
    • Zeleznik-Le, N.J.1    Harden, A.M.2    Rowley, J.D.3
  • 20
    • 0028169259 scopus 로고
    • ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional transactivation potential in lymphoid and myeloid cells
    • Rubnitz JE, Morrissey J, Savage PA, Cleary ML. ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional transactivation potential in lymphoid and myeloid cells. Blood 1994; 84: 1747-1752.
    • (1994) Blood , vol.84 , pp. 1747-1752
    • Rubnitz, J.E.1    Morrissey, J.2    Savage, P.A.3    Cleary, M.L.4
  • 21
    • 0032190230 scopus 로고    scopus 로고
    • AT-hook motifs identified in a wide variety of DNA-binding proteins
    • Aravind L, Landsman D. AT-hook motifs identified in a wide variety of DNA-binding proteins. Nucleic Acids Res 1998; 26: 4413-4421.
    • (1998) Nucleic Acids Res , vol.26 , pp. 4413-4421
    • Aravind, L.1    Landsman, D.2
  • 22
    • 0025753468 scopus 로고
    • Separate elements cause lineage restriction and specify boundaries of Hox1.1 expression
    • Püschel AW, Balling R, Gruss P. Separate elements cause lineage restriction and specify boundaries of Hox1.1 expression. Development 1991; 112: 279-287.
    • (1991) Development , vol.112 , pp. 279-287
    • Püschel, A.W.1    Balling, R.2    Gruss, P.3
  • 23
    • 0028929415 scopus 로고
    • A conserved enhancer of the human and murine Hoxa7 gene specifies the anterior boundary of expression during embryonal development
    • Knittel T, Kessel M, Kim MH, Gruss P. A conserved enhancer of the human and murine Hoxa7 gene specifies the anterior boundary of expression during embryonal development. Development 1995; 121: 1077-1088.
    • (1995) Development , vol.121 , pp. 1077-1088
    • Knittel, T.1    Kessel, M.2    Kim, M.H.3    Gruss, P.4
  • 24
    • 0030571481 scopus 로고    scopus 로고
    • Sequence and functional analysis of an upstream regulatory region of human HOXA7 gene
    • Min W, Cho M, Jang SI, Chang HH, Lee CS, Jun MH, Kim MH. Sequence and functional analysis of an upstream regulatory region of human HOXA7 gene. Gene 1996; 182: 1-6.
    • (1996) Gene , vol.182 , pp. 1-6
    • Min, W.1    Cho, M.2    Jang, S.I.3    Chang, H.H.4    Lee, C.S.5    Jun, M.H.6    Kim, M.H.7
  • 25
    • 0029128120 scopus 로고
    • 2 macroglobulin gene confers LIF-induced transcriptional activation in embryonal stem cells
    • 2 macroglobulin gene confers LIF-induced transcriptional activation in embryonal stem cells. Cytokine 1995; 7: 491-502.
    • (1995) Cytokine , vol.7 , pp. 491-502
    • Hocke, G.M.1    Cui, M.-Z.2    Fey, G.H.3
  • 26
    • 0344198239 scopus 로고
    • Versatile retroviral vectors for potential use in gene therapy
    • Hawley RG, Lieu FHL, Fong AZC, Hawley TS. Versatile retroviral vectors for potential use in gene therapy. Gene Therapy 1994; 4: 436-438.
    • (1994) Gene Therapy , vol.4 , pp. 436-438
    • Hawley, R.G.1    Lieu, F.H.L.2    Fong, A.Z.C.3    Hawley, T.S.4
  • 27
    • 0027080293 scopus 로고
    • DEAE-dextran enhances electroporation of mammalian cells
    • Gauss GH, Lieber MR. DEAE-dextran enhances electroporation of mammalian cells. Nucleic Acids Res 1992; 20: 6739-6740.
    • (1992) Nucleic Acids Res , vol.20 , pp. 6739-6740
    • Gauss, G.H.1    Lieber, M.R.2
  • 28
    • 0030905542 scopus 로고    scopus 로고
    • The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures
    • Butler LH, Slany RK, Cui X, Cleary ML, Mason DY. The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures. Blood 1997; 89: 3361-3370.
    • (1997) Blood , vol.89 , pp. 3361-3370
    • Butler, L.H.1    Slany, R.K.2    Cui, X.3    Cleary, M.L.4    Mason, D.Y.5
  • 29
    • 0028985626 scopus 로고
    • Organization, sequence and regulation of the murine Hoxa7 gene
    • Parikh H, Shah S, Hilt D, Peterofsky A. Organization, sequence and regulation of the murine Hoxa7 gene. Gene 1995; 154: 237-242.
    • (1995) Gene , vol.154 , pp. 237-242
    • Parikh, H.1    Shah, S.2    Hilt, D.3    Peterofsky, A.4
  • 30
    • 0030806686 scopus 로고    scopus 로고
    • The FEL (AF-4) protein donates transcriptional activation sequences to HRX-FEL fusion proteins in leukemias containing t(4;11)(q21;23) chromosomal translocations
    • Morrissey JJ, Raney S, Cleary ML. The FEL (AF-4) protein donates transcriptional activation sequences to HRX-FEL fusion proteins in leukemias containing t(4;11)(q21;23) chromosomal translocations. Leukemia Res 1997; 21: 911-917.
    • (1997) Leukemia Res , vol.21 , pp. 911-917
    • Morrissey, J.J.1    Raney, S.2    Cleary, M.L.3
  • 31
    • 0029930974 scopus 로고    scopus 로고
    • Infant leukemia biology, aetiology and treatment
    • Greaves MF. Infant leukemia biology, aetiology and treatment. Leukemia 1996; 10: 372-377.
    • (1996) Leukemia , vol.10 , pp. 372-377
    • Greaves, M.F.1
  • 32
    • 0030029955 scopus 로고    scopus 로고
    • The mixed lineage leukemia (MLL) protein involved in 11q23 translocations contains a domain that binds cruciform DNA and scaffold attachment region (SAR) DNA
    • Broeker PL, Harden A, Rowley JD, Zeleznik-Le N. The mixed lineage leukemia (MLL) protein involved in 11q23 translocations contains a domain that binds cruciform DNA and scaffold attachment region (SAR) DNA. Curr Top Microbiol Immunol 1996; 211: 259-268.
    • (1996) Curr Top Microbiol Immunol , vol.211 , pp. 259-268
    • Broeker, P.L.1    Harden, A.2    Rowley, J.D.3    Zeleznik-Le, N.4
  • 33
    • 0029665594 scopus 로고    scopus 로고
    • TFG3/TAF30/ANC1 a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9
    • Cairns B, Henry NL, Kornberg RD. TFG3/TAF30/ANC1 a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9. Mol Cell Biol 1996; 16: 3308-3316.
    • (1996) Mol Cell Biol , vol.16 , pp. 3308-3316
    • Cairns, B.1    Henry, N.L.2    Kornberg, R.D.3
  • 35
    • 0033559686 scopus 로고    scopus 로고
    • A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos
    • Carr AC, Biggin MD. A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos. EMBO J 1999; 18: 1598-1608.
    • (1999) EMBO J , vol.18 , pp. 1598-1608
    • Carr, A.C.1    Biggin, M.D.2
  • 36
    • 0031001394 scopus 로고    scopus 로고
    • An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer dependent transcription in vitro
    • Bagga R, Emerson BM. An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer dependent transcription in vitro. Genes Dev 1997; 11: 629-639.
    • (1997) Genes Dev , vol.11 , pp. 629-639
    • Bagga, R.1    Emerson, B.M.2
  • 37
    • 84936073167 scopus 로고
    • The high motility group protein HMCI(Y) is required for NFkappaB-dependent virus induction of the human IFNbeta gene
    • Thanos D, Maniatis T. The high motility group protein HMCI(Y) is required for NFkappaB-dependent virus induction of the human IFNbeta gene. Cell 1992; 71: 691-700.
    • (1992) Cell , vol.71 , pp. 691-700
    • Thanos, D.1    Maniatis, T.2
  • 38
    • 0026697174 scopus 로고
    • 2+ binding regulatory domain
    • 2+ binding regulatory domain. EMBO J 1992; 11: 2611-2617.
    • (1992) EMBO J , vol.11 , pp. 2611-2617
    • Bestor, T.H.1
  • 39
    • 0030977310 scopus 로고    scopus 로고
    • A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins
    • Cross SH, Meehan RR, Nan X, Bird A. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat Genet 1997; 16: 256-259.
    • (1997) Nat Genet , vol.16 , pp. 256-259
    • Cross, S.H.1    Meehan, R.R.2    Nan, X.3    Bird, A.4
  • 40
    • 0003187137 scopus 로고
    • Epigenetic regulation in Drosophila: A conspiracy of silence
    • Hames BD, Glover DM (eds). IRL Press at Oxford University Press: Oxford
    • Eissenberg JC, Elgin SCR, Paro R. Epigenetic regulation in Drosophila: a conspiracy of silence. In: Hames BD, Glover DM (eds). Chromatin Structure and Gene Expression. IRL Press at Oxford University Press: Oxford, 1995, pp 147-165.
    • (1995) Chromatin Structure and Gene Expression , pp. 147-165
    • Eissenberg, J.C.1    Elgin, S.C.R.2    Paro, R.3
  • 41
    • 0030790432 scopus 로고    scopus 로고
    • Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein
    • Yano T, Nakamura T, Blechman J, Sorio C, Dang CV, Geiger B, Canaani E. Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein. Proc Natl Acad Sci USA 1997; 94: 7286-7291.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7286-7291
    • Yano, T.1    Nakamura, T.2    Blechman, J.3    Sorio, C.4    Dang, C.V.5    Geiger, B.6    Canaani, E.7
  • 43
    • 0029954818 scopus 로고    scopus 로고
    • The role of hox homeobox genes in normal and leukemic hematopoiesis
    • Lawrence HJ, Sauvageau G, Humphries RK, Largman C. The role of hox homeobox genes in normal and leukemic hematopoiesis. Stem Cells 1996; 14: 281-291.
    • (1996) Stem Cells , vol.14 , pp. 281-291
    • Lawrence, H.J.1    Sauvageau, G.2    Humphries, R.K.3    Largman, C.4
  • 44
    • 0032519809 scopus 로고    scopus 로고
    • Stage-specific expression of polycomb group genes in human bone marrow cells
    • Lessard J, Baban S, Sauvageau G. Stage-specific expression of polycomb group genes in human bone marrow cells. Blood 1998; 91: 1216-1224.
    • (1998) Blood , vol.91 , pp. 1216-1224
    • Lessard, J.1    Baban, S.2    Sauvageau, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.