Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2

Circulation

Volumn 110, Issue 15, 2004, Pages 2132-2136

  Spiecker, Martin ^a   Darius, Harald ^c   Hankeln, Thomas ^d   Soufi, Muhidien ^e   Sattler, Alexander M ^e   Schaefer, Jürgen R ^e   Node, Koichi ^f   Börgel, Jan ^a   Mügge, Andreas ^a   Lindpaintner, Klaus ^g,h   Huesing, Anika ^b   Maisch, Bernhard ^e   Zeldin, Darryl C ⁱ   Liao, James K ^g  

^a ST JOSEF HOSPITAL   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d GENterprise GmbH   (Germany)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

^f SAGA UNIVERSITY   (Japan)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h F HOFFMANN LA ROCHE LTD   (Switzerland)

ⁱ NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Atherosclerosis; Coronary disease; Genetics; Inflammation; Molecular biology

Indexed keywords

CYTOCHROME P450 2J2; CYTOCHROME P450 ISOENZYME; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORONARY RISK; CYP2J2 GENE; ENZYME POLYMORPHISM; GENE; GENETIC RISK; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING;

3' UNTRANSLATED REGIONS; 8,11,14-EICOSATRIENOIC ACID; AGED; AMINO ACID SUBSTITUTION; ARACHIDONIC ACID; BASE SEQUENCE; BINDING SITES; CORONARY DISEASE; CYTOCHROME P-450 ENZYME SYSTEM; DNA MUTATIONAL ANALYSIS; EICOSANOIDS; EXONS; FEMALE; GENETIC SCREENING; GENOTYPE; GERMANY; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; INTRONS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OXYGENASES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RISK; SEQUENCE ANALYSIS, DNA; SP1 TRANSCRIPTION FACTOR;

EID: 20844452556     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000143832.91812.60     Document Type: Article

References (14)

1. Wu S, Moomaw CR, Tomer KB, et al. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J Biol Chem. 1996;271:3460-3468.
2. Node K, Huo Y, Ruan X, et al. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science. 1999;285: 1276-1279.
3. Collins T, Cybulsky MI. NF-κB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest. 2001;107:255-264.
4. Oilman CL, Weintraub NL, VanRollins M, et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ Res. 1998;83:932-939.
5. Pinto A, Abraham NG, Mullane KM. Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway. J Pharmacol Exp Ther. 1987; 240:856-863.
6. Fisslthaler B, Popp R, Kiss L, et al. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature. 1999;401:493-497.
7. s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J Biol Chem. 2001;276:15983-15989.
8. Sun J, Sui X, Bradbury JA, et al. Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circ Res. 2002;90:1020-1027.
9. Guengerich FP. Human cytochrome P-450 enzymes. Life Sci. 1992;50: 1471-1478.
10. Wolf CR, Miles JS, Gough A, et al. Molecular genetics of the human cytochrome P-450 system. Biochem Soc Trans. 1990;18:21-24.
11. King LM, Ma J, Srettabunjong S, et al. Cloning of CYP2J2 gene and identification of functional polymorphisms. Mol Pharmacol. 2002;61: 840-852.
12. Spiecker M, Lorenz I, Marx N, et al. Tranilast inhibits cytokine-induced nuclear factor kB activation in vascular endothelial cells. Mol Pharmacol. 2002;62:856-863.
13. VanRollins M, Kaduce TL, Knapp HR, et al. 14,15-Epoxyeicosatrienoic acid metabolism in endothelial cells. J Lipid Res. 1993;34:1931-1942.
14. Sinal CJ, Miyata M, Tohkin M, et al. Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem. 2000;275:40504-40510.