Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)- bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors

Journal of Medicinal Chemistry

Volumn 50, Issue 15, 2007, Pages 3627-3644

  Bunnelle, William H ^a   Daanen, Jerome F ^a   Ryther, Keith B ^a   Schrimpf, Michael R ^a   Dart, Michael J ^a   Gelain, Arianna ^b   Meyer, Michael D ^a   Frost, Jennifer M ^a   Anderson, David J ^a   Buckley, Michael ^a   Curzon, Peter ^a   Cao, Ying Jun ^a   Puttfarcken, Pamela ^a   Searle, Xenia ^a   Ji, Anguo ^a   Putman, C Brent ^a   Surowy, Carol ^a   Toma, Lucio ^c   Barlocco, Daniela ^b  

^a ABBOTT LABORATORIES   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 CHLORO 3 PYRIDINYL) 2,5 DIAZABICYCLO[2.2.1]HEPTANE 4 TOLUENESULFONATE; 2 (6 CHLORO 5 HYDROXY 3 PYRIDINYL) 2,5 DIAZABICYCLO[2.2.1]HEPTANE 4 TOLUENESULFONATE; EPIBATIDINE; NICOTINIC AGENT; PYRIDINE; TOLUENESULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYDROPHILICITY; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANALGESICS; ANIMALS; BINDING, COMPETITIVE; BRAIN; CELL LINE; DIAMINES; DOPAMINE; HETEROCYCLIC COMPOUNDS, BRIDGED-RING; LIGANDS; MODELS, MOLECULAR; NICOTINIC AGONISTS; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; PYRIDINES; RATS; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34547642298     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070018l     Document Type: Article

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