Synthesis and Muscarinic Receptor Activity of Ester Derivatives of 2-Substituted 2-Azabicyclo[2.2.1]heptan-5-ol and -6-ol

Journal of Medicinal Chemistry

Volumn 35, Issue 12, 1992, Pages 2184-2191

  Carroll, F Ivy ^a,b   Abraham, Phillip ^a,b   Chemburkar, Sanjay ^a,b   He, Xu chang ^a,b   Mascarella, S Wayne ^a,b   Kwon, Yong Wha ^a,b   Triggle, David J ^a,b  

^a RTI INTERNATIONAL   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID 2 METHYL 2 AZABICYCLO[2.2.1]HEPT 5 YL ESTER; ACETIC ACID DERIVATIVE; AZAPROPHEN; DRUG CARRIER; ESTER DERIVATIVE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; RADIOLIGAND; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CELL CULTURE; CELL MEMBRANE; CHO CELL; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HEART; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMAL; AZA COMPOUNDS; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; BRAIN; CELL MEMBRANE; CHO CELLS; COMPARATIVE STUDY; HAMSTERS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCARINE; MYOCARDIUM; PARASYMPATHOMIMETICS; QUINUCLIDINYL BENZILATE; RATS; RATS, INBRED STRAINS; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION;

EID: 0026734203     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00090a006     Document Type: Article

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