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Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 3, 2002, Pages 1246-1252

Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine

(5) Avalos, Melva a Parker, Michael J b Maddox, Floyd N a Ivy Carroll, F b Luetje, Charles W a,b

a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE (United States)

b RTI INTERNATIONAL (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINONORCHLOROEPIBATIDINE; BROMONORCHLOROEPIBATIDINE; DIMETHYLAMINONORCHLOROEPIBATIDINE; EPIBATIDINE; EPIBATIDINE DERIVATIVE; FLUORONORCHLOROEPIBATIDINE; HYDROXYNORCHLOROEPIBATIDINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NORCHLOROEPIBATIDINE; RECEPTOR SUBTYPE; TRIFLUOROMETHANESULFONATE NORCHLOROEPIBATIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; NEURONS; NICOTINIC AGONISTS; OOCYTES; PATCH-CLAMP TECHNIQUES; PERIPHERAL NERVOUS SYSTEM; PYRIDINES; RATS; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0036721041 PISSN: 00223565 EISSN: None Source Type: Journal
DOI: 10.1124/jpet.102.035899 Document Type: Article

Times cited : (37)

References (29)

1
- 0031443680
- Neuronal nicotinic acetylcholine receptor activation modulates γ-aminobutyric acid release from CA1 neurons of rat hippocampal slices
- (1998) J Pharmacol Exp Ther , vol.283 , pp. 1396-1411
- Alkondon, M.¹ Pereira, E.F.² Barbosa, C.T.³ Albuquerque, E.X.⁴

2
- 0028230727
- Epibatidine, a potent analgetic and nicotinic agonist
- (1994) Mol Pharmacol , vol.45 , pp. 563-569
- Badio, B.¹ Daly, J.W.²

3
- 0031053794
- Synthesis and nicotinic activity of epiboxidine: An isoxazole analogue of epibatidine
- (1997) Eur J Pharmacol , vol.321 , pp. 189-194
- Badio, B.¹ Garraffo, H.M.² Plummer, C.V.³ Padgett, W.L.⁴ Daly, J.W.⁵

4
- 0028905669
- Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine
- (1995) J Pharmacol Exp Ther , vol.272 , pp. 1199-1203
- Bonhaus, D.W.¹ Bley, K.R.² Broka, C.A.³ Fontana, D.J.⁴ Leung, E.⁵ Lewis, R.⁶ Shiieh, A.⁷ Wong, E.H.F.⁸

5
- 0343378913
- The pharmacology of (-)-nicotine and novel cholinergic channel modulators
- (1997) Adv Pharmacol , vol.37 , pp. 153-213
- Brioni, J.D.¹ Decker, M.W.² Sullivan, J.P.³ Arneric, S.P.⁴

6
- 0033814977
- The unusual nature of epibatidine responses at the α4β2 nicotinic acetylcholine receptor
- (2000) Neuropharmacology , vol.39 , pp. 2561-2569
- Buisson, B.¹ Vallejo, Y.F.² Green, W.N.³ Bertrand, D.⁴

7
- 0035927437
- Synthesis, nicotinic acetylcholine receptor binding and antinociceptive properties of 2-exo-2-(2′-substituted 5′-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues
- (2001) J Med Chem , vol.44 , pp. 2229-2237
- Carroll, F.I.¹ Liang, F.² Navarro, H.A.³ Brieaddy, L.E.⁴ Abraham, P.⁵ Damaj, I.I.⁶ Martin, B.R.⁷

8
- 0015861774
- 50) of an enzymatic reaction
- (1973) Biochem Pharmacol , vol.22 , pp. 3099-3108
- Cheng, Y.C.¹ Prusoff, W.H.²

9
- 17544372511
- Nicotinic receptors at the amino acid level
- (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 431-458
- Corringer, P.J.¹ Le Novere, N.² Changeux, J.P.³

10
- 0028883095
- Diversity of neuronal nicotinic acetylcholine receptors: Lessons from behavior and implications for CNS therapeutics
- (1995) Life Sci , vol.56 , pp. 545-570
- Decker, M.W.¹ Brioni, J.D.² Bannon, A.W.³ Arneric, S.P.⁴

11
- 0035852933
- α 10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
- (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3501-3506
- Elgoyhen, A.B.¹ Vetter, D.E.² Katz, E.³ Rothlin, C.V.⁴ Heinemann, S.F.⁵ Boulter, J.⁶

12
- 0028838303
- Comparative pharmacology of epibatidine: A potent agonist for neuronal nicotinic acetylcholine receptors
- (1995) Mol Pharmacol , vol.48 , pp. 774-782
- Gerzanich, V.¹ Peng, X.² Wang, F.³ Wells, G.⁴ Anand, R.⁵ Fletcher, S.⁶ Lindstrom, J.⁷

13
- 0029936826
- Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine α4/β2 receptor
- (1996) J Pharmacol Exp Ther , vol.276 , pp. 289-297
- Gopalakrishnan, M.¹ Monteggia, L.M.² Anderson, D.J.³ Molinari, E.J.⁴ Piattoni-Kaplan, M.⁵ Donnelly-Roberts, D.⁶ Arneric, S.P.⁷ Sullivan, J.P.⁸

14
- 0029889642
- Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor β subunits
- (1996) J Neurosci , vol.16 , pp. 3798-3806
- Harvey, S.C.¹ Luetje, C.W.²

15
- 0345434817
- Regional distribution of nicotinic receptor subunit mRNAs in human brain: Comparison between Alzheimer and normal brain
- (1999) Mol Brain Res , vol.66 , pp. 94-103
- Hellstrom-Lindahl, E.¹ Mousavi, M.² Zhang, X.³ Ravid, R.⁴ Nordberg, A.⁵

16
- 14444267817
- 11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors
- (1998) J Med Chem , vol.41 , pp. 4199-4206
- Horti, A.G.¹ Scheffel, U.² Kimes, A.S.³ Musachio, J.L.⁴ Ravert, H.T.⁵ Mathews, W.B.⁶ Zhan, Y.⁷ Finley, P.A.⁸ London, E.D.⁹ Daniels, R.F.¹⁰

17
- 0037022640
- 2+-binding sites
- (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3210-3215
- Le Novere, N.¹ Grutter, T.² Changeux, J.P.³

18
- 0026485457
- Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs
- (1992) Neuron , vol.9 , pp. 861-871
- Liman, E.R.¹ Tytgat, J.² Hess, P.³

19
- 0032970174
- International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits
- (1999) Pharmacol Rev , vol.51 , pp. 397-401
- Lucas, R.J.¹ Changeux, J.P.² Le Novere, N.³ Albuquerque, E.X.⁴ Balfour, D.J.K.⁵ Berg, D.K.⁶ Bertrand, D.⁷ Chiappinelli, V.A.⁸ Clarke, P.B.S.⁹ Collins, A.C.¹⁰

20
- 0032438649
- Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity
- (1998) Mol Pharmacol , vol.54 , pp. 1132-1139
- Parker, M.J.¹ Beck, A.² Luetje, C.W.³

21
- 0034802363
- Determinants of agonist binding affinity on neuronal nicotinic receptor β subunits
- (2001) J Pharmacol Exp Ther , vol.299 , pp. 385-391
- Parker, M.J.¹ Harvey, S.C.² Luetje, C.W.³

22
- 0034017540
- Nicotinic receptors in the brain: Links between molecular biology and behavior
- (2000) Neuropsychopharmacology , vol.22 , pp. 451-465
- Picciotto, M.R.¹ Caldarone, B.J.² King, S.L.³ Zachariou, V.⁴

23
- 0027767522
- Epibatidine is a nicotinic analgesic
- (1993) Eur J Pharmacol , vol.250
- Qian, C.¹ Li, T.² Shen, T.Y.³ Libertine-Garahan, L.⁴ Eckman, J.⁵ Biftu, T.⁶ Ip, S.⁷

24
- 0034638247
- Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization
- (2000) J Comp Neurol , vol.425 , pp. 58-69
- Quik, M.¹ Polonskaya, Y.² Gillespie, A.³ Jakowec, M.⁴ Lloyd, G.K.⁵ Langston, J.W.⁶

25
- 0027443439
- Multiple spinal mediators in parental nicotine induced antinociception
- (1993) J Pharmacol Exp Ther , vol.267 , pp. 341-349
- Rogers, D.T.¹ Iwamoto, E.T.²

26
- 0033925760
- Chemical modification of epibatidine causes a switch from agonist to antagonist and modifies its selectivity for neuronal nicotinic acetylcholine receptors
- (2000) Chem Biol , vol.7 , pp. 545-555
- Spang, J.E.¹ Bertrand, S.² Westera, G.³ Patt, J.T.⁴ Schubiger, P.A.⁵ Bertrand, D.⁶

27
- 0028172276
- (±)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors
- (1994) J Pharmacol Exp Ther , vol.271 , pp. 624-631
- Sullivan, J.P.¹ Decker, M.W.² Brioni, J.D.³ Donnelly-Roberts, D.⁴ Anderson, D.J.⁵ Bannon, A.W.⁶ Kang, C.-H.⁷ Adams, P.⁸ Piattoni-Kaplan, M.⁹ Buckley, M.J.¹⁰

28
- 0029815970
- Nicotinic receptors in the brain: Molecular biology, function and therapeutics
- (1996) Mol Chem Neuropathol , vol.28 , pp. 3-11
- Vidal, C.¹

29
- 0033232716
- Multiorgan autonomic dysfunction in mice lacking the β2 and the β4 subunits of neuronal nicotinic acetylcholine receptors
- (1999) J Neurosci , vol.19 , pp. 9298-9305
- Xu, W.¹ Orr-Urtreger, A.² Nigro, F.³ Gelber, S.⁴ Sutcliffe, C.B.⁵ Armstrong, D.⁶ Patrick, J.W.⁷ Role, L.W.⁸ Beaudet, A.L.⁹ De Biasi, M.¹⁰

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.