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Volumn 2, Issue 1, 1996, Pages 21-39

Epibatidine: Pharmacological properties of a novel nicotinic acetylcholine receptor agonist and analgesic agent

Author keywords

analgesia; epibatidine; ion channels; nicotinic receptor

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; 3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; ALPHA BUNGAROTOXIN; ANALGESIC AGENT; ATROPINE; CHLORISONDAMINE; CYTISINE; DIHYDRO BETA ERYTHROIDINE; EPIBATIDINE; HEXAMETHONIUM; ION CHANNEL; MECAMYLAMINE; NALOXONE; NEUROTOXIN; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; PEMPIDINE; RADIOLIGAND; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; S 1663; SCOPOLAMINE; UNCLASSIFIED DRUG; YOHIMBINE;

EID: 0029921513     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.1996.tb00288.x     Document Type: Review
Times cited : (68)

References (68)
  • 1
    • 84910908793 scopus 로고
    • Enantiomers of epibatidine as potent nicotinic agonists at two identified subtypes of nicotinic acetylcholine receptors (nAChRs) in rat hippocampal neurons
    • Alkondon M, Albuquerque EX. Enantiomers of epibatidine as potent nicotinic agonists at two identified subtypes of nicotinic acetylcholine receptors (nAChRs) in rat hippocampal neurons. Soc Neurosci 1994;20:467.8.
    • (1994) Soc Neurosci , vol.20
    • Alkondon, M.1    Albuquerque, E.X.2
  • 3
    • 0028343246 scopus 로고
    • (S)-3-Methyl-5-(1-Methyl-2-Pyrrolidinyl)Isoxazole (ABT-418): A novel cholinergic ligand with cognition enhancing and anxiolytic activity. I. In vitro activity
    • Arneric SP, Sullivan JP, Briggs CA, et al. (S)-3-Methyl-5-(1-Methyl-2-Pyrrolidinyl)Isoxazole (ABT-418): A novel cholinergic ligand with cognition enhancing and anxiolytic activity. I. In vitro activity. J Pharmacol Exp Ther 1994;270:310-317.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 310-317
    • Arneric, S.P.1    Sullivan, J.P.2    Briggs, C.A.3
  • 4
    • 0003113946 scopus 로고
    • Neuronal nicotinic acetylcholine receptors: Novel targets for CNS therapeutics
    • Bloom F E and Kupfer D J eds. New York: Raven
    • Arneric SP, Sullivan JP, Williams M. Neuronal nicotinic acetylcholine receptors: Novel targets for CNS therapeutics. In Bloom F E and Kupfer D J eds. Psychopharmacology: Fourth Generation of Progress, Vol. 5. New York: Raven, 1995;94-110.
    • (1995) Psychopharmacology: Fourth Generation of Progress , vol.5 , pp. 94-110
    • Arneric, S.P.1    Sullivan, J.P.2    Williams, M.3
  • 5
    • 0003043534 scopus 로고
    • Nicotinic agonists in Alzheimer's disease: Does the molecular diversity of nicotine receptors offer the opportunity for developing CNS-selective cholinergic channel activators?
    • Racagni G, Brunello N, Langer S Z eds. Basel: Karger
    • Arneric SP, Williams M. Nicotinic agonists in Alzheimer's disease: Does the molecular diversity of nicotine receptors offer the opportunity for developing CNS-selective cholinergic channel activators? In Racagni G, Brunello N, Langer S Z eds. Recent Advances in the Treatment of Neurodegenerative Disorders and Cognitive Dysfunction., Vol. 7. Basel: Karger, 1994;58-70.
    • (1994) Recent Advances in the Treatment of Neurodegenerative Disorders and Cognitive Dysfunction , vol.7 , pp. 58-70
    • Arneric, S.P.1    Williams, M.2
  • 6
    • 0028230727 scopus 로고
    • Epibatidine, a potent analgetic and nicotinic agonist
    • Badio B, Daly JW. Epibatidine, a potent analgetic and nicotinic agonist. Mol Pharmacol 1994;45:563-569.
    • (1994) Mol Pharmacol , vol.45 , pp. 563-569
    • Badio, B.1    Daly, J.W.2
  • 7
    • 0001679612 scopus 로고
    • Epibatidine: Discovery and definition as a potent analgesic and nicotinic agonist
    • Badio B, Garraffo HM, Spande TF, Daly JW, Epibatidine: Discovery and definition as a potent analgesic and nicotinic agonist. Med Chem Res 1994;4:440-448.
    • (1994) Med Chem Res , vol.4 , pp. 440-448
    • Badio, B.1    Garraffo, H.M.2    Spande, T.F.3    Daly, J.W.4
  • 8
    • 0028997458 scopus 로고
    • Is epibatidine really analgesic? Dissociation of the locomotor activity, temperature, and analgesic effects of (±)-epibatidine
    • Bannon AW, Gunther KL, Decker MW. Is epibatidine really analgesic? Dissociation of the locomotor activity, temperature, and analgesic effects of (±)-epibatidine. Pharmacol Biochem Behav 1995;51:693-698.
    • (1995) Pharmacol Biochem Behav , vol.51 , pp. 693-698
    • Bannon, A.W.1    Gunther, K.L.2    Decker, M.W.3
  • 9
    • 0028933123 scopus 로고
    • The influence of Bay K 8644 treatment on (±)-epibatidine-induced analgesia
    • Bannon AW, Gunther KL, Decker MW, Arneric SP. The influence of Bay K 8644 treatment on (±)-epibatidine-induced analgesia. Brain Res 1995;678:244-250.
    • (1995) Brain Res , vol.678 , pp. 244-250
    • Bannon, A.W.1    Gunther, K.L.2    Decker, M.W.3    Arneric, S.P.4
  • 10
    • 0024819194 scopus 로고
    • Effect of nicotine on the release of acetylcholine and amino acids in the brain
    • Beani L, Bianchi C, Ferraro L, et al. Effect of nicotine on the release of acetylcholine and amino acids in the brain. Prog Brain Res 1989;79:149-155.
    • (1989) Prog Brain Res , vol.79 , pp. 149-155
    • Beani, L.1    Bianchi, C.2    Ferraro, L.3
  • 11
    • 0026343407 scopus 로고
    • Nicotine and coronary heart disease
    • Benowitz NL. Nicotine and coronary heart disease. Trends Cardiovasc Med 1992;1:315-321.
    • (1992) Trends Cardiovasc Med , vol.1 , pp. 315-321
    • Benowitz, N.L.1
  • 12
    • 0028905669 scopus 로고
    • Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine
    • Bonhaus DW, Bley KR, Broka CA, et al. Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine. J Pharmacol Exp Ther 1995;272:1199-1203.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 1199-1203
    • Bonhaus, D.W.1    Bley, K.R.2    Broka, C.A.3
  • 13
    • 0342713112 scopus 로고    scopus 로고
    • The pharmacology of epibatidine and ABT-418 on putative subtypes of rat neuronal nicotinic receptors
    • in press
    • Boulton BA, Thinschmidt JS, Quintana R, Meyer EM, Papke RL. The pharmacology of epibatidine and ABT-418 on putative subtypes of rat neuronal nicotinic receptors. Mol Pharmacol 1996, in press.
    • (1996) Mol Pharmacol
    • Boulton, B.A.1    Thinschmidt, J.S.2    Quintana, R.3    Meyer, E.M.4    Papke, R.L.5
  • 14
  • 15
    • 0027420050 scopus 로고
    • Nicotinic receptor agonists facilitate retention of avoidance training: Participation of dopaminergic mechanisms
    • Brioni JD, Arneric SP. Nicotinic receptor agonists facilitate retention of avoidance training: Participation of dopaminergic mechanisms. Behav Neural Biol 1993;59:57-62.
    • (1993) Behav Neural Biol , vol.59 , pp. 57-62
    • Brioni, J.D.1    Arneric, S.P.2
  • 17
    • 0027232237 scopus 로고
    • Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test
    • Brioni JK, O'Neill AB, Kim DJB, Decker MW. Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test. Eur J Pharmacol 1993;238:1-8.
    • (1993) Eur J Pharmacol , vol.238 , pp. 1-8
    • Brioni, J.K.1    O'Neill, A.B.2    Kim, D.J.B.3    Decker, M.W.4
  • 18
    • 0001650460 scopus 로고
    • Synthetic approaches to epibatidine
    • Broka CA. Synthetic approaches to epibatidine. Med Chem Res 1994;4:449-460.
    • (1994) Med Chem Res , vol.4 , pp. 449-460
    • Broka, C.A.1
  • 23
    • 0000205033 scopus 로고
    • Analgesic activity of epibatidine and its enantiomers in a chemical model of pain in mice
    • Damaj MI, Tucker SM, Aceto MD, Martin BR. Analgesic activity of epibatidine and its enantiomers in a chemical model of pain in mice. Med Chem Res 1994;4:483-492.
    • (1994) Med Chem Res , vol.4 , pp. 483-492
    • Damaj, M.I.1    Tucker, S.M.2    Aceto, M.D.3    Martin, B.R.4
  • 24
    • 0027855978 scopus 로고
    • Involvement of calcium and L-type channels in nicotine-induced antinociception
    • Damaj MI, Welch SP, Martin BR. Involvement of calcium and L-type channels in nicotine-induced antinociception. J Pharmacol Exp Ther 1993;266:1330-1338.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 1330-1338
    • Damaj, M.I.1    Welch, S.P.2    Martin, B.R.3
  • 25
    • 0028243316 scopus 로고
    • (S)-3-Methyl-5-(1-Methyl-2-Pyrrolidinyl)Isoxazole(ABT-418): A novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization
    • Decker MW, Brioni JD, Sullivan JP et al. (S)-3-Methyl-5-(1-Methyl-2-Pyrrolidinyl)Isoxazole(ABT-418): A novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. J Pharmacol Exp Ther 1994;270:319-328.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 319-328
    • Decker, M.W.1    Brioni, J.D.2    Sullivan, J.P.3
  • 26
    • 0026503635 scopus 로고
    • Effects of nicotine on spatial memory deficits in rats with medial septal lesions
    • Decker MW, Majchrzak MJ, Anderson DJ. Effects of nicotine on spatial memory deficits in rats with medial septal lesions. Brain Res 1992;572:281-285.
    • (1992) Brain Res , vol.572 , pp. 281-285
    • Decker, M.W.1    Majchrzak, M.J.2    Anderson, D.J.3
  • 27
    • 0025851708 scopus 로고
    • The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory
    • Decker MW, Mc Gaugh JL. The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 1991;7:151-168.
    • (1991) Synapse , vol.7 , pp. 151-168
    • Decker, M.W.1    Mc Gaugh, J.L.2
  • 28
    • 0025968656 scopus 로고
    • Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors
    • Deneris ES, Connolly J, Rogers SW, Duvoisin R. Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors. Trends Pharmacol Sci 1991;12:34-40.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 34-40
    • Deneris, E.S.1    Connolly, J.2    Rogers, S.W.3    Duvoisin, R.4
  • 29
    • 0028171296 scopus 로고
    • Alpha-9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells
    • Elogoyhen AB, Johnson D, Boulter J, Vetter D, Heineman SF. Alpha-9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 1994;79:705-715.
    • (1994) Cell , vol.79 , pp. 705-715
    • Elogoyhen, A.B.1    Johnson, D.2    Boulter, J.3    Vetter, D.4    Heineman, S.F.5
  • 30
    • 0028037690 scopus 로고
    • Epibatidine, an alkaloid from the poison frog Epipedobates tricolor, is a powerful ganglionic depolarizing agent
    • Fischer M, Huangfu D, T.Y.S, Guynet PG. Epibatidine, an alkaloid from the poison frog Epipedobates tricolor, is a powerful ganglionic depolarizing agent. J Pharmacol Exp Ther 1994;270:702-708.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 702-708
    • Fischer, M.1    Huangfu, D.2    S., T.Y.3    Guynet, P.G.4
  • 31
    • 0026593533 scopus 로고
    • A subtype of nicotinic cholinergic receptor is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment
    • Flores CM, Rogers SW, Pabreza LA, Wolfe B, Kellar KJ. A subtype of nicotinic cholinergic receptor is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment. Mol Pharmacol 1992;41:31-37.
    • (1992) Mol Pharmacol , vol.41 , pp. 31-37
    • Flores, C.M.1    Rogers, S.W.2    Pabreza, L.A.3    Wolfe, B.4    Kellar, K.J.5
  • 32
    • 0028177088 scopus 로고
    • Homomers of α8 and α7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties
    • Gerzanich V, Anand R, Lindstrom J. Homomers of α8 and α7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties. Mol Pharmacol 1994;45:212-220.
    • (1994) Mol Pharmacol , vol.45 , pp. 212-220
    • Gerzanich, V.1    Anand, R.2    Lindstrom, J.3
  • 33
    • 0028838303 scopus 로고
    • Comparative pharmacology of epibatidine, a potent selective agonist for neuronal nicotinic acetylcholine receptors
    • Gerzanich V, Peng X, Wells G, et al. Comparative pharmacology of epibatidine, a potent selective agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol 1995;48:776-782.
    • (1995) Mol Pharmacol , vol.48 , pp. 776-782
    • Gerzanich, V.1    Peng, X.2    Wells, G.3
  • 34
    • 0000949429 scopus 로고
    • Epibatidine-aided studies towards definition of a nicotine receptor pharmacophore
    • Glennon RA, Herndon JL, Dukat M. Epibatidine-aided studies towards definition of a nicotine receptor pharmacophore. Med Chem Res 1994;4:461-473.
    • (1994) Med Chem Res , vol.4 , pp. 461-473
    • Glennon, R.A.1    Herndon, J.L.2    Dukat, M.3
  • 35
    • 0028984455 scopus 로고
    • Pharmacological characterization of the human a7 neuronal nicotinic acetylcholine receptor subtype stably expressed in a mammalian cell line
    • Gopalakrishnan M, Buisson B, Touma E, et al. Pharmacological characterization of the human a7 neuronal nicotinic acetylcholine receptor subtype stably expressed in a mammalian cell line. Eur J Pharmacol 1995;290:237-246.
    • (1995) Eur J Pharmacol , vol.290 , pp. 237-246
    • Gopalakrishnan, M.1    Buisson, B.2    Touma, E.3
  • 39
  • 41
    • 9344224258 scopus 로고
    • Mapping determinants of competitive antagonist sensitivity on neuronal nicotinic receptor subunits
    • Clarke PBS, Quik M, Thorseau K, Alkondon F eds. Basel: Birkhausar Verlag
    • Luetje CW, Harvey SC, Maddox F. Mapping determinants of competitive antagonist sensitivity on neuronal nicotinic receptor subunits. In Clarke PBS, Quik M, Thorseau K, Alkondon F eds. International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II. Basel: Birkhausar Verlag, 1994:13.
    • (1994) International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II , pp. 13
    • Luetje, C.W.1    Harvey, S.C.2    Maddox, F.3
  • 42
    • 0025934097 scopus 로고
    • Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors
    • Luetje CW, Patrick J. Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J Neurosci 1991;11:837-845.
    • (1991) J Neurosci , vol.11 , pp. 837-845
    • Luetje, C.W.1    Patrick, J.2
  • 43
    • 0027375195 scopus 로고
    • Expression of ganglia-type nicotinic acetylcholine receptors and nicotinic ligand binding sites by cells of the IMR-32 human neuroblastoma clonal cell line
    • Lukas RJ. Expression of ganglia-type nicotinic acetylcholine receptors and nicotinic ligand binding sites by cells of the IMR-32 human neuroblastoma clonal cell line. J Pharmacol Exp Ther 1993;265:294-302.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 294-302
    • Lukas, R.J.1
  • 44
    • 0023845177 scopus 로고
    • Methyllycaconitine and (+)-anatoxin-A differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems
    • Macallan DR, Lunt GG, Wonnacott S, Swanson KL, Rapoport H, Albuquerque EX. Methyllycaconitine and (+)-anatoxin-A differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems. FEBS Lett 1988;226:357-363.
    • (1988) FEBS Lett , vol.226 , pp. 357-363
    • Macallan, D.R.1    Lunt, G.G.2    Wonnacott, S.3    Swanson, K.L.4    Rapoport, H.5    Albuquerque, E.X.6
  • 45
    • 0027759941 scopus 로고
    • Nicotinic receptor function determined by stimulation of rubidium efflux from mouse brain synaptosomes
    • Marks MJ, Garnham DA, Grady SR, Collins AC. Nicotinic receptor function determined by stimulation of rubidium efflux from mouse brain synaptosomes. J Pharmacol Exp Ther 1993;264:542-552.
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 542-552
    • Marks, M.J.1    Garnham, D.A.2    Grady, S.R.3    Collins, A.C.4
  • 46
    • 0023029997 scopus 로고
    • Nicotinic binding sites in rat and mouse brain: Comparison of acetylcholine, nicotine, and α-bungarotoxin
    • Marks MJ, Stitzel A, Romm E, Wehner JM, Collins AC. Nicotinic binding sites in rat and mouse brain: Comparison of acetylcholine, nicotine, and α-bungarotoxin. Mol Pharmacol 1986;30:427-436.
    • (1986) Mol Pharmacol , vol.30 , pp. 427-436
    • Marks, M.J.1    Stitzel, A.2    Romm, E.3    Wehner, J.M.4    Collins, A.C.5
  • 47
    • 0021049819 scopus 로고
    • Pharmacology of opioid receptors
    • Martin WR. Pharmacology of opioid receptors. Pharmacol Rev 1983;35:283-323.
    • (1983) Pharmacol Rev , vol.35 , pp. 283-323
    • Martin, W.R.1
  • 50
    • 0025924689 scopus 로고
    • 3H]Cytisine binding to nicotinic cholinergic receptors in brain
    • 3H]Cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 1991;41:9-12.
    • (1991) Mol Pharmacol , vol.41 , pp. 9-12
    • Pabreza, L.A.1    Dhawan, S.2    Kellar, K.J.3
  • 54
    • 0027998167 scopus 로고
    • Antinociceptive and toxic effects of (+)-epibatidine oxalate attributable to nicotinic agonist activity
    • Rupniak NMJ, Patel S, Marwood R, et al. Antinociceptive and toxic effects of (+)-epibatidine oxalate attributable to nicotinic agonist activity. Br J Pharmacol 1994;113:1487-1493.
    • (1994) Br J Pharmacol , vol.113 , pp. 1487-1493
    • Rupniak, N.M.J.1    Patel, S.2    Marwood, R.3
  • 55
    • 0018642954 scopus 로고
    • Antinociceptive effects of central and systemic administration of nicotine in the rat
    • Sahley TL, Bernston GG. Antinociceptive effects of central and systemic administration of nicotine in the rat. Psychopharmacology 1979;65:279-283.
    • (1979) Psychopharmacology , vol.65 , pp. 279-283
    • Sahley, T.L.1    Bernston, G.G.2
  • 56
    • 0027398069 scopus 로고
    • The diversity of neuronal nicotinic acetylcholine receptors
    • Sargent PB. The diversity of neuronal nicotinic acetylcholine receptors. Ann Rev Neurosci 1993;16:403-443.
    • (1993) Ann Rev Neurosci , vol.16 , pp. 403-443
    • Sargent, P.B.1
  • 57
    • 0027518923 scopus 로고
    • Molecular cloning, functional properties and distribution of rat brain a7; a nicotinic cation channel highly permeable to calcium
    • Seguela P, Wadiche J, Dineley-Miller K, Dani JA, Partick JW. Molecular cloning, functional properties and distribution of rat brain a7; a nicotinic cation channel highly permeable to calcium. J Neurosci 1993;13:596-604.
    • (1993) J Neurosci , vol.13 , pp. 596-604
    • Seguela, P.1    Wadiche, J.2    Dineley-Miller, K.3    Dani, J.A.4    Partick, J.W.5
  • 58
    • 84986984213 scopus 로고
    • Synthesis and biological evaluation of (±)-epibatidine and the congeners
    • Senokuchi K, Nakai H, Kawamura M, et al. Synthesis and biological evaluation of (±)-epibatidine and the congeners. Syn Lett 1994;343-344.
    • (1994) Syn Lett , pp. 343-344
    • Senokuchi, K.1    Nakai, H.2    Kawamura, M.3
  • 59
    • 0026551490 scopus 로고
    • Epibatidine: A novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog
    • Spande TF, Garraffo HM, Edwards MW, Yeh HJC, Pannell L, Daly JW. Epibatidine: A novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog. J Am Chem Soc 1992;114:3475-3478.
    • (1992) J Am Chem Soc , vol.114 , pp. 3475-3478
    • Spande, T.F.1    Garraffo, H.M.2    Edwards, M.W.3    Yeh, H.J.C.4    Pannell, L.5    Daly, J.W.6
  • 60
    • 0000727741 scopus 로고
    • (±)-Epibatidine can differentially evoke responses mediated by putative subtypes of nicotinic acetylcholine receptors (nAChRs)
    • Sullivan JP, Briggs CA, Donnelly-Roberts D, et al. (±)-Epibatidine can differentially evoke responses mediated by putative subtypes of nicotinic acetylcholine receptors (nAChRs). Med Chem Res 1994;4: 502-516.
    • (1994) Med Chem Res , vol.4 , pp. 502-516
    • Sullivan, J.P.1    Briggs, C.A.2    Donnelly-Roberts, D.3
  • 61
    • 0028172276 scopus 로고
    • (±)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors
    • Sullivan JP, Decker MW, Brioni JD, et al. (±)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors. J Pharmacol Exp Ther 1994;271:324-331.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 324-331
    • Sullivan, J.P.1    Decker, M.W.2    Brioni, J.D.3
  • 62
    • 0346213872 scopus 로고
    • Stable expression and pharmacologic properties of the human neuronal nicotinic acetylcholine receptor alpha4beta2 subtype
    • Sullivan JP, Monteggia LM, Anderson DJ, Giordano TG, Arneric SP, Gopalakrishnan M. Stable expression and pharmacologic properties of the human neuronal nicotinic acetylcholine receptor alpha4beta2 subtype. FASEB J 1995;9:S2262.
    • (1995) FASEB J , vol.9
    • Sullivan, J.P.1    Monteggia, L.M.2    Anderson, D.J.3    Giordano, T.G.4    Arneric, S.P.5    Gopalakrishnan, M.6
  • 63
    • 0026007054 scopus 로고
    • Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts
    • Whiting P, Schoepfer R, Lindstrom J, Priestly T. Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts. Mol Pharmacol 1992;40:463-472.
    • (1992) Mol Pharmacol , vol.40 , pp. 463-472
    • Whiting, P.1    Schoepfer, R.2    Lindstrom, J.3    Priestly, T.4
  • 64
    • 0028859846 scopus 로고
    • Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, α3β4, expressed in transfected eucaryotic cells
    • Wong ET, Holstad SG, Mennerick SJ, Hong SE, Zorumski CF, Isenberg KE. Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, α3β4, expressed in transfected eucaryotic cells. Mol Brain Res 1995;28:101-109.
    • (1995) Mol Brain Res , vol.28 , pp. 101-109
    • Wong, E.T.1    Holstad, S.G.2    Mennerick, S.J.3    Hong, S.E.4    Zorumski, C.F.5    Isenberg, K.E.6
  • 65
    • 0000158143 scopus 로고
    • Methyllycaconitine: A new probe that discriminates between nicotinic acetylcholine receptor subclasses
    • Wonnacott S, Albuquerque EX, Bertrand D. Methyllycaconitine: A new probe that discriminates between nicotinic acetylcholine receptor subclasses. Meth Neurosci 1993;12:263-275.
    • (1993) Meth Neurosci , vol.12 , pp. 263-275
    • Wonnacott, S.1    Albuquerque, E.X.2    Bertrand, D.3
  • 66
    • 0024987190 scopus 로고
    • Presynaptic nicotinic receptors and the modulation of transmission release
    • G. B. a. J. Marsh (Eds.), Chichester: Wiley
    • Wonnacott S, Drasdo A, Sanderson E, Rowell P. Presynaptic nicotinic receptors and the modulation of transmission release. In G. B. a. J. Marsh (Eds.), The Biology of Nicotine Dependence. Chichester: Wiley, 1990:87-105.
    • (1990) The Biology of Nicotine Dependence , pp. 87-105
    • Wonnacott, S.1    Drasdo, A.2    Sanderson, E.3    Rowell, P.4
  • 67
    • 0024803782 scopus 로고
    • Presynaptic modulation of transmitter release by nicotinic receptors
    • Nordberg A., Fuxe K., Holmstedt B., Sundwall A. eds. Amsterdam: Elsevier
    • Wonnacott S, Irons J, Rapier C, Thorne B, Lunt GG. Presynaptic modulation of transmitter release by nicotinic receptors. In Nordberg A., Fuxe K., Holmstedt B., Sundwall A. eds. Progress in Brain Research Amsterdam: Elsevier, 1990;80:157-163.
    • (1990) Progress in Brain Research , vol.80 , pp. 157-163
    • Wonnacott, S.1    Irons, J.2    Rapier, C.3    Thorne, B.4    Lunt, G.G.5
  • 68
    • 0025786515 scopus 로고
    • Nicotinic pharmacology of anatoxin analogs II. Side chain structure-activity relationships at neuronal nicotinic ligand binding sites
    • Wonnacott S, Jackman JL, Swanson KL, Rapoport H, Albuquerque EX. Nicotinic pharmacology of anatoxin analogs II. Side chain structure-activity relationships at neuronal nicotinic ligand binding sites. J Pharmacol Exp Ther 1991;259:387-391.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 387-391
    • Wonnacott, S.1    Jackman, J.L.2    Swanson, K.L.3    Rapoport, H.4    Albuquerque, E.X.5


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