Epibatidine: A Novel (Chloropyridy1)azabicycloheptane with Potent Analgesic Activity from an Ecuadoran Poison Frog

Journal of the American Chemical Society

Volumn 114, Issue 9, 1992, Pages 3475-3478

  Spande, Thomas F ^a   Garraffo, Hugo Martin ^a   Edwards, Michael W ^a   Yeh, Herman J C ^a   Pannell, Lewis ^a   Daly, John W ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; ANALGESIC AGENT; EPIBATIDINE;

ANIMAL TISSUE; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; FROG; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SKIN;

EID: 0026551490     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja00035a048     Document Type: Article

References (11)

1. Daly, J. W.; Tokuyama, T.; Fujiwara, T.; Highet, R. J.; Karle, I. L. J. Am. Chem. Soc. 1980, 102, 830-836.
2. Aceto, M. D.; McKean, D. B.; Pearl, J. Br. J. Pharmacol. 1969, 36, 225-239.
3. Daly, J. W.; Brown, G. B.; Mensah-Dwumah, M.; Myers, C. W. Toxicon 1978, 16, 163-188.
4. Daly, J. W.; Myers, C. W.; Whittaker, N. Toxicon 1987, 25, 1023-1095.
5. Aldrich Library of FTIR spectra, Vapor Phase Spectra, 1st ed.; Pouchert, C. J. Ed.; Aldrich Chemical Co.: Milwaukee, WI, 1989; Vol. 3;.
6. Kricka, L. J.; Vernon, J. M. Adv. Heterocycl. Chem. 1974, 16, 87.
7. La Planche, L. A.; Rogers, M. T. J. Am. Chem. Soc. 1963, 85, 3728-3730.
8. Busby, R. E.; Iqbal, M.; Khan, M. A.; Parrick, J.; Shaw, C. J. G. J. Chem. Soc., Perkin Trans. 1 1979, 1578-1582.
9. Fraser, R. R.; Swingle, R. B. Can. J. Chem. 1970, 48, 2065-2074.
10. Anet, F. A. L. Can. J. Chem. 1961, 39, 789-794.
11. Ramey, K. C.; Lini, D. C.; Moriarty, R. M.; Gopal, H.; Welsh, H. G. J. Am. Chem. Soc. 1967, 89, 2401-2408.