2-(aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 19, 1996, Pages 2283-2288

  Elliott, Richard L ^b   Kopecka, Hana ^b   Gunn, David E ^b   Lin, Nan Horng ^b   Garvey, David S ^a   Ryther, Keith B ^b   Holladay, Mark W ^b   Anderson, David J ^b   Campbell, Jeffrey E ^b   Sullivan, James P ^b   Buckley, Michael J ^b   Gunther, Karen L ^b   O'Neill, Alyssa B ^b   Decker, Michael W ^b   Arneric', Stephen P ^b  

^a NitroMed Research Laboratories   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AZETIDINE DERIVATIVE; NICOTINIC RECEPTOR; PYRROLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MASS SPECTROMETRY; MEMORY; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; REACTION ANALYSIS;

EID: 0030575611     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00416-7     Document Type: Article

References (36)

1. 1. Abreo, M. A.; Lin, N. H.; Garvey, D. S.; Gunn, D. E.; Hettinger, A-M.; Wasicak, J. T.; Pavlik, P. A.; Martin, Y. C.; Donnelly-Roberts, D. L.; Anderson, D. J.; Sullivan, J. P.; Williams, M.; Arneric, S. P.; Holladay, M. W. J. Med. Chem. 1996, 39, 817.
2. 2. Williams, M.; Sullivan, J. P.; Arneric', S. P. Drug News Perspect.. 1994, 7, 205.
3. 3. Arneric', S. P.; Williams, M. In Recent Advances in the Treatment of Neurodegenerative Disorders and Cognitive Function; Racagni, G.; Brunello, N.; Langer, S. Z., Ed.; Karger: Basel, 1994; Vol. 7, pp 58-70.
4. 4. Arneric', S. P.; Sullivan, J. P.; Williams, M., In Psychopharmacology: The Fourth Generation of Progress; Bloom, F. E.; Kupfer, D. J., Ed.; Raven: New York, 1995, Ch. 9.
5. 5. Court J. A.; Perry, E. K. CNS Drugs 1994, 2, 216.
6. 6. Benowitz, N. L. New England J. Med. 1988, 319, 1318.
7. 7. Deneris, E. S.; Connolly, J.; Rogers, S. W.; Duvoisin, R. Trends Pharmacol. Sci. 1991, 12, 34.
8. 8. Role, L. Curr. Opin. Neurobiol. 1992, 2, 254.
9. 9. Sargent, P. B. Annu. Rev. Neurosci. 1993, 16, 403.
10. 10. Galzi, J.-L.; Changeux, J.-P. Neuropharmacol. 1995, 34, 563.
11. 11. Lucas, R. J. Annals Of The New York Academy Of Sciences 1995, 757, 153.
12. 12. Lindstrom, J.; Anand, R.; Peng, X.; Gerzanich, V.; Wang F; Li, Y. Annals Of The New York Academy Of Sciences 1995, 757, 100.
13. 13. Arneric' S. P., Williams M. In Recent Advances In The Treatment of Neurodegenerative Disorders and Cognitive Funcition Int. Acad. Biomed. Drug Res. Vol 7, 30, 1993.
14. 14. Holladay, M. W.; Lebold, S. A.; Lin, N. H. Drug Development Research 1995, 35, 191.
15. 15. Whitehouse, P. J.; Martino A. M.; Wagster, M. V.; Price, D. L.; Mayeux, R., Atach, J. R.-Keilar, K. J. Neurology 1988, 38, 720.
16. 16. Sugaya, K.; Giacobini, Chiappinelli, V. A. J. Neurosci. Res. 1990, 27, 349.
17. 17. Brioni, J. D.; Arneric', S. A. Behavioral and Neural Biology 1993, 59, 57.
18. 18. Decker, M. W.; Majchrzak, M. J.; Anderson, D. J. Brain Research 1992, 572, 281.
19. 19. Levin, E. D. Psychopharmacology 1992,108, 417.
20. 20. Bovet, D.; Bovet-Nitti, F.; Olivero, A. Psychopharmacol. 1966, 10, 1.
21. 21. Evangelista, A. M.; Gattoni, R. C.; Izquierdo, I. Pharmacology 1970, 3, 91.
22. 22. Haroutunian, V.; Barnes, E.; Davies, K. L. Psychopharmacol. 1985, 87, 266.
23. 23. Gray, J. A.; Mitchell, S. N.; Joseph, M. H.; Grigoryan, G.; Dawe, S.; Hodges, H. Drug Dev. Res 1994, 31, 3.
24. 24. Elrod, K.; Buccafusco, J. J.; Jackson, W. J. Life Sciences 1988, 43, 277.
25. 25. Buccafusco, J.; Jackson, W. Neurobiology of Aging 1991, 12, 233.
26. 26. Sahakian, B.; Jones, G.; Levy, R., Gray; J.; Warburton, D. British Journal of Psych. 1989, 154, 797.
27. 27. Jones, G. M. M.; Sahakian, B. J.; Levy, R.; Warburton, D. M.; Gray, J. A. Psychopharmacol. 1992, 108, 485.
28. 28. Newhouse, P. A.; Sunderland, T.; Tariot, P. N.; Blumhardt, C. L.; Weingartner, H.; Mellow, A.; Murphy, D. L. Psychopharmacology 1988, 95, 171.
29. 29. (a) Garvey, D. S.; Wasicak, J. T.; Decker, M. W.; Brioni, J. D.; Buckley, M. J.; Sullivan, J. P.; Carrera, G. M.; Holladay, M. W.; Arneric', S. P.; Williams, M. J. Med. Chem. 1994, 37, 1055.
30. (b) Garvey, D. S.; Wasicak, J. T.; Elliott, R. L.; Lebold, S. A.; Hettinger, A-M.; Carrera, G. M.; Lin, N. H.; He, Y.; Holladay, M. W.; Anderson, D. J.; Cadman, E. D.; Raszkiewicz, J. L.; Sullivan, J. P.; and Arneric', S. P. J. Med. Chem. 1994, 37 , 4455.
31. 30. Lin, N. H.; He, Y.; Arneric', S. P.; Sullivan, J. P. Bioorg. Med. Chem. Lett. 1995, 5, 1141.
32. 31. Arneric', S. P.; Sullivan, J. P.; Briggs, C. A; Donnelly-Roberts, D.; Anderson, D. J.; Raszkiewicz, J. L.; Hughes, M.; Cadman, E. D.; Adams, P.; Garvey, D. S.; Wasicak, J.; Williams, M. J. Pharmacol. Exp. Therap. 1994, 270 , 310.
33. 32. Decker, M. W.; Brioni, J. D.; Sullivan, J. P.; Buckley, M. J.; Radek, R. J.; Raszkiewicz, J. L.; Kang, C. H.; Kim, D. J. B.; Giardina, W. J.; Wasicak, J.; Garvey, D. S.; Williams, M.; Arneric', S. P. J. Pharm. Exp. Ther. 1994, 270, 319.
34. 33. Elliott, R. L.; Ryther, K. B; Anderson, D. J.; Raszkiewicz, J. L.; Campbell, J. E.; Sullivan, J. P.; Garvey, D. S. Bioorg. Med. Chem. Lett. 1995, 5, 991.
35. 34. Pabreza, L. A.; Dhawan, S.; Kellar, K. J. Mol. Pharmacol. 1991, 39, 9.
36. 35. Beers, W. H.; Reich, E. Nature (London) 1970, 228, 917.