Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes

Journal of Medicinal Chemistry

Volumn 45, Issue 14, 2002, Pages 3041-3047

  Cheng, Jie ^a   Zhang, Chunming ^a   Stevens, Edwin D ^a   Izenwasser, Sari ^b   Wade, Dean ^a   Chen, Shaoyi ^b   Paul, Dennis ^c   Trudell, Mark L ^a  

^a UNIVERSITY OF NEW ORLEANS   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 AZABICYCLO[2.2.1]HEPTANE DERIVATIVE; ALKYL GROUP; BICYCLO COMPOUND; CHLORINE DERIVATIVE; CYTISINE; EPIBATIDINE; HEPTANE; HETEROCYCLIC COMPOUND; LIGAND; N (3 PYRIDYLMETHYL) 7 AZABICYCLO[2.2.1]HEPTANE; N [(2 CHLORO 5 PYRIDYL)METHYL] 7 AZABICYCLO[2.2.1]HEPTANE; NICOTINIC RECEPTOR; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN TISSUE; DOSE RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; RAT; TAIL FLICK TEST;

ANALGESICS, NON-NARCOTIC; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BODY TEMPERATURE; BRAIN; CRYSTALLOGRAPHY, X-RAY; DOPAMINE; INJECTIONS, SPINAL; LIGANDS; MICE; NICOTINIC AGONISTS; PAIN MEASUREMENT; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037019265     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0103561     Document Type: Article

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