Synthesis and biological evaluation of N-pyrazolyl-N′-alkyl/benzyl/ phenylureas: A new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis

Journal of Medicinal Chemistry

Volumn 50, Issue 15, 2007, Pages 3618-3626

  Bruno, Olga ^a   Brullo, Chiara ^a   Bondavalli, Francesco ^a   Schenone, Silvia ^a   Ranise, Angelo ^a   Arduino, Nicoletta ^a   Bertolotto, Maria B ^a   Montecucco, Fabrizio ^a   Ottonello, Luciano ^a   Dallegri, Franco ^a   Tognolini, Massimiliano ^b   Ballabeni, Vigilio ^b   Bertoni, Simona ^b   Barocelli, Elisabetta ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 HYDROXY 2 PHENYLETHYL) 5 (3 PHENYLUREIDO) 1H PYRAZOLE 4 CARBOXYLIC ACID ETHYL ESTER; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; F ACTIN; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE MODEL; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OVARY INFLAMMATION; PERITONITIS; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOPODIUM; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ACTINS; ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS; CHEMOTAXIS, LEUKOCYTE; HUMANS; INTERLEUKIN-8; MALE; MICE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PERITONEAL CAVITY; PERITONITIS; PHENYLUREA COMPOUNDS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PSEUDOPODIA; PYRAZOLES; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34547563852     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0704402     Document Type: Article

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