A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit

Journal of Immunology

Volumn 169, Issue 11, 2002, Pages 6435-6444

  Podolin, Patricia L ^a   Bolognese, Brian J ^a   Foley, James J ^a   Schmidt, Dulcie B ^a   Buckley, Peter T ^a   Widdowson, Katherine L ^a   Jin, Qi ^a   White, John R ^a   Lee, Judithann M ^a   Goodman, Richard B ^b   Hagen, Tonja R ^b   Kajikawa, Osamu ^b   Marshall, Lisa A ^a   Hay, Douglas W P ^a   Sarau, Henry M ^a  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 8; LEUKOTRIENE B4; LEUKOTRIENE C4; LIGAND; LIPOPOLYSACCHARIDE; N [3 (AMINOSULFONYL) 4 CHLORO 2 HYDROXYPHENYL] N' (2,3 DICHLOROPHENYL) UREA; PROSTAGLANDIN E2; RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DRUG DERIVATIVE; N (3 (AMINOSULFONYL) 4 CHLORO 2 HYDROXYPHENYL) N' (2,3 DICHLOROPHENYL)UREA; N-(3-(AMINOSULFONYL)-4-CHLORO-2-HYDROXYPHENYL)-N'-(2,3-DICHLOROPHENYL)UREA; NONSTEROID ANTIINFLAMMATORY AGENT; OVALBUMIN; RECOMBINANT PROTEIN; UREA;

ANIMAL MODEL; ARTHRITIS; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; INFLAMMATION; JOINT DESTRUCTION; KNEE; LEUKOCYTE MIGRATION; LYMPHOCYTE; MONOCYTE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABBIT; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; ACUTE DISEASE; ANIMAL; CHRONIC DISEASE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; IN VITRO STUDY; METABOLISM;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CHEMOTAXIS, LEUKOCYTE; CHRONIC DISEASE; FEMALE; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; NEUTROPHILS; OVALBUMIN; RABBITS; RECEPTORS, INTERLEUKIN-8B; RECOMBINANT PROTEINS; UREA;

EID: 0036884730     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.11.6435     Document Type: Article

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