Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d] pyrimidines 4-amino substituted and their biological evaluation

European Journal of Medicinal Chemistry

Volumn 39, Issue 2, 2004, Pages 153-160

  Schenone, Silvia ^a   Bruno, Olga ^a   Bondavalli, Francesco ^a   Ranise, Angelo ^a   Mosti, Luisa ^a   Menozzi, Giulia ^a   Fossa, Paola ^a   Manetti, Fabrizio ^b   Morbidelli, Lucia ^b   Trincavelli, Letizia ^c   Martini, Claudia ^c   Lucacchini, Antonio ^c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

Adenosine; Epidermal growth factor; Pyrazolo pyrimidines

Indexed keywords

1 (2 HYDROXY 2 PHENYLETHYL) 6 (METHYLTHIO) 1,5 DIHYDRO 4H PYRAZOLO[3,4 D]PYRIMIDIN 4 ONE; 1 (2 HYDROXY 2 PHENYLETHYL) 6 THIOXO 1,5,6,7 TETRAHYDRO 4H PYRAZOLO[3,4 D]PYRIMIDIN 4 ONE; 4 CHLORO 1 (2 CHLORO 2 PHENYLETHYL) 6 (METHYLTHIO) 1H PYRAZOLO[3,4 D]PYRIMIDNE; 4 CHLORO 6 (METHYLTHIO) 1 (2 PHENYLVINYL) 1H PYRAZOLO[3,4 D]PYRIMIDINE; ADENOSINE A1 RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ETHYL 5 [[(BENZOYLAMINO)CARBONOTHIOYL]AMINO] 1 (2 HYDROXY 2 PHENYLETHYL) 1H PYRAZOLE 4 CARBOXYLATE; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; EVALUATION; HUMAN; HUMAN CELL; PHOSPHORYLATION; RECEPTOR AFFINITY;

EID: 10744224155     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2003.11.007     Document Type: Article

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