메뉴 건너뛰기




Volumn 110, Issue 2, 2007, Pages 686-694

Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; CD135 ANTIGEN;

EID: 34547120985     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-10-053181     Document Type: Article
Times cited : (28)

References (64)
  • 1
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 2
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia. 1997;11:1605-1609.
    • (1997) Leukemia , vol.11 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3
  • 3
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 4
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3:650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 5
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia. 1998;12:1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3
  • 6
    • 0035383768 scopus 로고    scopus 로고
    • FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood. 2001;97:3589-3595.
    • (2001) Blood , vol.97 , pp. 3589-3595
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 7
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S, Woods WG, Stirewalt DL, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood. 2001;97:89-94.
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.G.2    Stirewalt, D.L.3
  • 8
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002;100:59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 9
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 10
    • 0001097136 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children
    • Xu F, Taki T, Yang HW, et al. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol. 1999;105:155-162.
    • (1999) Br J Haematol , vol.105 , pp. 155-162
    • Xu, F.1    Taki, T.2    Yang, H.W.3
  • 11
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H, Naoe T, Nakano Y, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074-3080.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3
  • 12
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 13
    • 0033758958 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group
    • Abu-Duhier FM, Goodeve AC, Wilson GA, et al. FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group. Br J Haematol. 2000;111:190-195.
    • (2000) Br J Haematol , vol.111 , pp. 190-195
    • Abu-Duhier, F.M.1    Goodeve, A.C.2    Wilson, G.A.3
  • 14
    • 16944366584 scopus 로고    scopus 로고
    • Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
    • Horiike S, Yokota S, Nakao M, et al. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia. 1997;11:1442-1446.
    • (1997) Leukemia , vol.11 , pp. 1442-1446
    • Horiike, S.1    Yokota, S.2    Nakao, M.3
  • 15
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 17
    • 0027130517 scopus 로고
    • Hematopoietic receptors of class III receptor-type tyrosine kinases
    • Rosnet O, Birnbaum D. Hematopoietic receptors of class III receptor-type tyrosine kinases. Crit Rev Oncog. 1993;4:595-613.
    • (1993) Crit Rev Oncog , vol.4 , pp. 595-613
    • Rosnet, O.1    Birnbaum, D.2
  • 18
    • 0025770646 scopus 로고
    • A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
    • Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell. 1991;65:1143-1152.
    • (1991) Cell , vol.65 , pp. 1143-1152
    • Matthews, W.1    Jordan, C.T.2    Wiegand, G.W.3    Pardoll, D.4    Lemischka, I.R.5
  • 19
    • 9244260192 scopus 로고    scopus 로고
    • Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells
    • Rosnet O, Buhring HJ, Marchetto S, et al. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia. 1996;10:238-248.
    • (1996) Leukemia , vol.10 , pp. 238-248
    • Rosnet, O.1    Buhring, H.J.2    Marchetto, S.3
  • 20
    • 0029998037 scopus 로고    scopus 로고
    • FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells
    • Turner AM, Lin NL, Issarachai S, Lyman SD, Broudy VC. FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells. Blood. 1996;88:3383-3390.
    • (1996) Blood , vol.88 , pp. 3383-3390
    • Turner, A.M.1    Lin, N.L.2    Issarachai, S.3    Lyman, S.D.4    Broudy, V.C.5
  • 21
    • 0036167084 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line
    • Srinivasa SP, Doshi PD. Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line. Leukemia. 2002;16:244-253.
    • (2002) Leukemia , vol.16 , pp. 244-253
    • Srinivasa, S.P.1    Doshi, P.D.2
  • 22
    • 0034649210 scopus 로고    scopus 로고
    • Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
    • Zhang S, Broxmeyer HE. Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. Biochem Biophys Res Commun. 2000;277:195-199.
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 195-199
    • Zhang, S.1    Broxmeyer, H.E.2
  • 23
    • 0034605042 scopus 로고    scopus 로고
    • Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
    • Zhang S, Fukuda S, Lee Y, et al. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J Exp Med. 2000;192:719-728.
    • (2000) J Exp Med , vol.192 , pp. 719-728
    • Zhang, S.1    Fukuda, S.2    Lee, Y.3
  • 24
    • 0033020705 scopus 로고    scopus 로고
    • Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells
    • Zhang S, Mantel C, Broxmeyer HE. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. J Leukoc Biol. 1999;65:372-380.
    • (1999) J Leukoc Biol , vol.65 , pp. 372-380
    • Zhang, S.1    Mantel, C.2    Broxmeyer, H.E.3
  • 25
    • 0034749999 scopus 로고    scopus 로고
    • Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
    • Adolfsson J, Borge OJ, Bryder D, et al. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity. 2001;15:659-669.
    • (2001) Immunity , vol.15 , pp. 659-669
    • Adolfsson, J.1    Borge, O.J.2    Bryder, D.3
  • 26
    • 0035807964 scopus 로고    scopus 로고
    • Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
    • Christensen JL, Weissman IL. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A. 2001;98:14541-14546.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14541-14546
    • Christensen, J.L.1    Weissman, I.L.2
  • 27
    • 0032519768 scopus 로고    scopus 로고
    • c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
    • Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101-1134.
    • (1998) Blood , vol.91 , pp. 1101-1134
    • Lyman, S.D.1    Jacobsen, S.E.2
  • 28
    • 0041743233 scopus 로고    scopus 로고
    • Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: Distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells
    • Sitnicka E, Buza-Vidas N, Larsson S, Nygren JM, Liuba K, Jacobsen SE. Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells. Blood. 2003;102:881-886.
    • (2003) Blood , vol.102 , pp. 881-886
    • Sitnicka, E.1    Buza-Vidas, N.2    Larsson, S.3    Nygren, J.M.4    Liuba, K.5    Jacobsen, S.E.6
  • 29
    • 1242315428 scopus 로고    scopus 로고
    • Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia
    • Stirewalt DL, Meshinchi S, Kussick SJ, et al. Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia. Br J Haematol. 2004;124:481-484.
    • (2004) Br J Haematol , vol.124 , pp. 481-484
    • Stirewalt, D.L.1    Meshinchi, S.2    Kussick, S.J.3
  • 30
    • 33645312560 scopus 로고    scopus 로고
    • Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML
    • Reindl C, Bagrintseva K, Vempati S, et al. Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. Blood. 2006;107:3700-3707.
    • (2006) Blood , vol.107 , pp. 3700-3707
    • Reindl, C.1    Bagrintseva, K.2    Vempati, S.3
  • 31
    • 19944427369 scopus 로고    scopus 로고
    • Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML)
    • Kindler TBF, Kasper S, Estey E, et al. Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). Blood. 2005;105:335-340.
    • (2005) Blood , vol.105 , pp. 335-340
    • Kindler, T.B.F.1    Kasper, S.2    Estey, E.3
  • 32
    • 0842310394 scopus 로고    scopus 로고
    • The structural basis for autoinhibition of FLT3 by the juxtamembrane domain
    • Griffith J, Black J, Faerman C, et al. The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol Cell. 2004;13:169-178.
    • (2004) Mol Cell , vol.13 , pp. 169-178
    • Griffith, J.1    Black, J.2    Faerman, C.3
  • 33
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 34
    • 0028258512 scopus 로고
    • Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line
    • Kanakura Y, Furitsu T, Tsujimura T, et al. Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. Leukemia. 1994;8(suppl 1):S18-S22.
    • (1994) Leukemia , vol.8 , Issue.SUPPL. 1
    • Kanakura, Y.1    Furitsu, T.2    Tsujimura, T.3
  • 35
    • 0028959163 scopus 로고
    • Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
    • Kitayama H, Kanakura Y, Furitsu T, et al. Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood. 1995;85:790-798.
    • (1995) Blood , vol.85 , pp. 790-798
    • Kitayama, H.1    Kanakura, Y.2    Furitsu, T.3
  • 36
    • 0034993741 scopus 로고    scopus 로고
    • Classes of c-KIT activating mutations: Proposed mechanisms of action and implications for disease classification and therapy
    • Longley BJ, Reguera MJ, Ma Y. Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy. Leuk Res. 2001;25:571-576.
    • (2001) Leuk Res , vol.25 , pp. 571-576
    • Longley, B.J.1    Reguera, M.J.2    Ma, Y.3
  • 37
    • 0037062350 scopus 로고    scopus 로고
    • PML/ RARalpha and FLT3-ITD induce an APL-like disease in a mouse model
    • Kelly LM, Kutok JL, Williams IR, et al. PML/ RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci. U S A. 2002;99:8283-8288.
    • (2002) Proc Natl Acad Sci. U S A , vol.99 , pp. 8283-8288
    • Kelly, L.M.1    Kutok, J.L.2    Williams, I.R.3
  • 38
    • 22144469473 scopus 로고    scopus 로고
    • Internal tandem duplications of the FLT3 gene are present in leukemia stem cells
    • Levis M, Murphy KM, Pham R, et al. Internal tandem duplications of the FLT3 gene are present in leukemia stem cells. Blood. 2005;106:673-680.
    • (2005) Blood , vol.106 , pp. 673-680
    • Levis, M.1    Murphy, K.M.2    Pham, R.3
  • 39
    • 0036736501 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 internal tandem repeat in patients with de novo acute myeloid leukemia treated with reinforced courses of chemotherapy
    • Boissel N, Cayuela JM, Preudhomme C, et al. Prognostic significance of FLT3 internal tandem repeat in patients with de novo acute myeloid leukemia treated with reinforced courses of chemotherapy. Leukemia. 2002;16:1699-1704.
    • (2002) Leukemia , vol.16 , pp. 1699-1704
    • Boissel, N.1    Cayuela, J.M.2    Preudhomme, C.3
  • 40
    • 12244282411 scopus 로고    scopus 로고
    • Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia
    • Moreno I, Martin G, Bolufer P, et al. Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia. Haematologica. 2003;88:19-24.
    • (2003) Haematologica , vol.88 , pp. 19-24
    • Moreno, I.1    Martin, G.2    Bolufer, P.3
  • 41
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: A study from the Acute Leukemia French Association (ALFA)
    • Preudhomme C, Sagot C, Boissel N, et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood. 2002;100:2717-2723.
    • (2002) Blood , vol.100 , pp. 2717-2723
    • Preudhomme, C.1    Sagot, C.2    Boissel, N.3
  • 42
    • 33750614145 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia
    • Pollard JA, Alonzo TA, Gerbing RB, et al. FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia. Blood. 2006;108:2764-2769.
    • (2006) Blood , vol.108 , pp. 2764-2769
    • Pollard, J.A.1    Alonzo, T.A.2    Gerbing, R.B.3
  • 43
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
    • Whitman SP, Archer KJ, Feng L, et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res. 2001;61:7233-7239.
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 44
    • 0037441745 scopus 로고    scopus 로고
    • The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3
    • Spiekermann K, Dirschinger RJ, Schwab R, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003;101:1494-1504.
    • (2003) Blood , vol.101 , pp. 1494-1504
    • Spiekermann, K.1    Dirschinger, R.J.2    Schwab, R.3
  • 45
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3
  • 46
    • 0037838661 scopus 로고    scopus 로고
    • Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
    • Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin Cancer Res. 2003;9:2140-2150.
    • (2003) Clin Cancer Res , vol.9 , pp. 2140-2150
    • Spiekermann, K.1    Bagrintseva, K.2    Schwab, R.3    Schmieja, K.4    Hiddemann, W.5
  • 47
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood. 2000;96:3907-3914.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3
  • 48
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 2002;5:433-443.
    • (2002) Cancer Cell , vol.5 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3
  • 49
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
    • Stone RM, DeAngelo DJ, Klimek V, et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood. 2005;105:54-60.
    • (2005) Blood , vol.105 , pp. 54-60
    • Stone, R.M.1    DeAngelo, D.J.2    Klimek, V.3
  • 51
    • 33646431111 scopus 로고    scopus 로고
    • Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al. Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia. Blood. 2006;107:3724-3726.
    • (2006) Blood , vol.107 , pp. 3724-3726
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 53
    • 9144269029 scopus 로고    scopus 로고
    • FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
    • Zheng R, Levis M, Piloto O, et al. FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood. 2004;103:267-274.
    • (2004) Blood , vol.103 , pp. 267-274
    • Zheng, R.1    Levis, M.2    Piloto, O.3
  • 54
    • 33747189188 scopus 로고    scopus 로고
    • Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
    • Rocnik JL, Okabe R, Yu JC, et al. Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. Blood. 2006;108:1339-1345.
    • (2006) Blood , vol.108 , pp. 1339-1345
    • Rocnik, J.L.1    Okabe, R.2    Yu, J.C.3
  • 55
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli M, Baer MR, Baumann H, Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood. 2003;101:2940-2954.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3    Wetzler, M.4
  • 56
    • 13344279401 scopus 로고    scopus 로고
    • STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
    • Gouilleux-Gruart V, Gouilleux F, Desaint C, et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood. 1996;87:1692-1697.
    • (1996) Blood , vol.87 , pp. 1692-1697
    • Gouilleux-Gruart, V.1    Gouilleux, F.2    Desaint, C.3
  • 57
    • 0031803213 scopus 로고    scopus 로고
    • Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia
    • Hayakawa F, Towatari M, Iida H, et al. Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia. Br J Haematol. 1998;101:521-528.
    • (1998) Br J Haematol , vol.101 , pp. 521-528
    • Hayakawa, F.1    Towatari, M.2    Iida, H.3
  • 58
    • 0032528191 scopus 로고    scopus 로고
    • Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts
    • Xia Z, Baer MR, Block AW, Baumann H, Wetzler M. Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts. Cancer Res. 1998;58:3173-3180.
    • (1998) Cancer Res , vol.58 , pp. 3173-3180
    • Xia, Z.1    Baer, M.R.2    Block, A.W.3    Baumann, H.4    Wetzler, M.5
  • 59
    • 0030609009 scopus 로고    scopus 로고
    • Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells
    • Lilly M, Kraft A. Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells. Cancer Res. 1997;57:5348-5355.
    • (1997) Cancer Res , vol.57 , pp. 5348-5355
    • Lilly, M.1    Kraft, A.2
  • 61
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • Levis M, Allebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99:3885-3891.
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Allebach, J.2    Tse, K.F.3
  • 62
    • 0013102301 scopus 로고    scopus 로고
    • CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
    • Kelly LM, Yu JC, Boulton CL, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell. 2002;1:421-432.
    • (2002) Cancer Cell , vol.1 , pp. 421-432
    • Kelly, L.M.1    Yu, J.C.2    Boulton, C.L.3
  • 63
    • 0037108298 scopus 로고    scopus 로고
    • SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
    • Yee KW, O'Farrell AM, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood. 2002;100:2941-2949.
    • (2002) Blood , vol.100 , pp. 2941-2949
    • Yee, K.W.1    O'Farrell, A.M.2    Smolich, B.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.