-
1
-
-
0027130517
-
Hematopoietic receptors of class III receptor-type tyrosine kinases
-
Rosnet O, Birnbaum D. Hematopoietic receptors of class III receptor-type tyrosine kinases. Crit Rev Oncog. 1993;4:595-613.
-
(1993)
Crit Rev Oncog
, vol.4
, pp. 595-613
-
-
Rosnet, O.1
Birnbaum, D.2
-
2
-
-
0028080987
-
Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells
-
Zeigler FC, Bennett BD, Jordan CT, et al. Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells. Blood. 1994;84:2422-2430.
-
(1994)
Blood
, vol.84
, pp. 2422-2430
-
-
Zeigler, F.C.1
Bennett, B.D.2
Jordan, C.T.3
-
3
-
-
18344418672
-
Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase
-
Rappold I, Ziegler BL, Kohler I, et al. Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. Blood. 1997;90:111-125.
-
(1997)
Blood
, vol.90
, pp. 111-125
-
-
Rappold, I.1
Ziegler, B.L.2
Kohler, I.3
-
4
-
-
0030702115
-
Synergistic action of Flt3 and gp130 signalings in human hematopoiesis
-
Ebihara Y, Tsuji K, Lyman SD, et al. Synergistic action of Flt3 and gp130 signalings in human hematopoiesis. Blood. 1997;90:4363-4368.
-
(1997)
Blood
, vol.90
, pp. 4363-4368
-
-
Ebihara, Y.1
Tsuji, K.2
Lyman, S.D.3
-
5
-
-
0032519768
-
c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activities
-
Lyman SD, Jacobsen SE. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 1998;91:1101-1134.
-
(1998)
Blood
, vol.91
, pp. 1101-1134
-
-
Lyman, S.D.1
Jacobsen, S.E.2
-
6
-
-
16944365287
-
Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: A study on a large series of patients and cell lines
-
Yokota S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia. 1997;11:1605-1609.
-
(1997)
Leukemia
, vol.11
, pp. 1605-1609
-
-
Yokota, S.1
Kiyoi, H.2
Nakao, M.3
-
7
-
-
0037409885
-
Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia
-
Kottaridis PD, Gale RE, Linch DC. Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia. Leuk Lymphoma. 2003;44:905-913.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 905-913
-
-
Kottaridis, P.D.1
Gale, R.E.2
Linch, D.C.3
-
8
-
-
0036659931
-
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
-
Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002; 100:59-66.
-
(2002)
Blood
, vol.100
, pp. 59-66
-
-
Schnittger, S.1
Schoch, C.2
Dugas, M.3
-
9
-
-
0035871889
-
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
-
Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
-
(2001)
Blood
, vol.97
, pp. 2434-2439
-
-
Yamamoto, Y.1
Kiyoi, H.2
Nakano, Y.3
-
10
-
-
0034936404
-
Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia
-
Abu-Duhier FM, Goodeve AC, Wilson GA, Care RS, Peake IR, Reilly JT. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Br J Haematol. 2001;113:983-988.
-
(2001)
Br J Haematol
, vol.113
, pp. 983-988
-
-
Abu-Duhier, F.M.1
Goodeve, A.C.2
Wilson, G.A.3
Care, R.S.4
Peake, I.R.5
Reilly, J.T.6
-
11
-
-
0037097716
-
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
-
(2002)
Blood
, vol.99
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
-
12
-
-
0036839326
-
A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia
-
Spiekermann K, Bagrintseva K, Schoch C, Haferlach T, Hiddemann W, Schnittger S. A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia. Blood. 2002;100:3423-3425.
-
(2002)
Blood
, vol.100
, pp. 3423-3425
-
-
Spiekermann, K.1
Bagrintseva, K.2
Schoch, C.3
Haferlach, T.4
Hiddemann, W.5
Schnittger, S.6
-
13
-
-
0036785393
-
Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: Implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
-
Kottaridis PD, Gale RE, Langabeer SE, Frew ME, Bowen DT, Linch DC. Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood. 2002;100:2393-2398.
-
(2002)
Blood
, vol.100
, pp. 2393-2398
-
-
Kottaridis, P.D.1
Gale, R.E.2
Langabeer, S.E.3
Frew, M.E.4
Bowen, D.T.5
Linch, D.C.6
-
14
-
-
0035885955
-
The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
-
Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
-
(2001)
Blood
, vol.98
, pp. 1752-1759
-
-
Kottaridis, P.D.1
Gale, R.E.2
Frew, M.E.3
-
15
-
-
0037114829
-
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
-
Frohling S, Schlenk RF, Breitruck J, et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood. 2002;100: 4372-4380.
-
(2002)
Blood
, vol.100
, pp. 4372-4380
-
-
Frohling, S.1
Schlenk, R.F.2
Breitruck, J.3
-
16
-
-
0034598830
-
Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
-
Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
-
(2000)
Oncogene
, vol.19
, pp. 624-631
-
-
Hayakawa, F.1
Towatari, M.2
Kiyoi, H.3
-
17
-
-
0034554796
-
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
-
Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood. 2000;96: 3907-3914.
-
(2000)
Blood
, vol.96
, pp. 3907-3914
-
-
Mizuki, M.1
Fenski, R.2
Halfter, H.3
-
18
-
-
0037838661
-
Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
-
Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin Cancer Res. 2003;9:2140-2150.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2140-2150
-
-
Spiekermann, K.1
Bagrintseva, K.2
Schwab, R.3
Schmieja, K.4
Hiddemann, W.5
-
19
-
-
0036093475
-
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
-
Kelly LM, Liu Q, Kutok JL, Williams IR, Boulton CL, Gilliland DG. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood. 2002;99:310-318.
-
(2002)
Blood
, vol.99
, pp. 310-318
-
-
Kelly, L.M.1
Liu, Q.2
Kutok, J.L.3
Williams, I.R.4
Boulton, C.L.5
Gilliland, D.G.6
-
20
-
-
0037944120
-
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
-
Mizuki M, Schwable J, Steur C, et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood. 2003;101:3164-3173.
-
(2003)
Blood
, vol.101
, pp. 3164-3173
-
-
Mizuki, M.1
Schwable, J.2
Steur, C.3
-
21
-
-
0024379951
-
A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity
-
Meyer T, Regenass U, Fabbro D, et al. A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int J Cancer. 1989;43:851-856.
-
(1989)
Int J Cancer
, vol.43
, pp. 851-856
-
-
Meyer, T.1
Regenass, U.2
Fabbro, D.3
-
22
-
-
0036595143
-
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
-
Weisberg E, Boulton C, Kelly LM, et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 2002;1:433-443.
-
(2002)
Cancer Cell
, vol.1
, pp. 433-443
-
-
Weisberg, E.1
Boulton, C.2
Kelly, L.M.3
-
23
-
-
11144221328
-
Use of PKC412 in patients with acute myeloid leukemia (AML)/high-risk myelodysplastic syndromes (MDS) characterized by wild-type (WT) or mutated FLT3: A randomized trial of two doses
-
Estey E, Fischer T, Giles F, et al. Use of PKC412 in patients with acute myeloid leukemia (AML)/high-risk myelodysplastic syndromes (MDS) characterized by wild-type (WT) or mutated FLT3: a randomized trial of two doses [abstract]. Blood. 2003;102:919a.
-
(2003)
Blood
, vol.102
-
-
Estey, E.1
Fischer, T.2
Giles, F.3
-
24
-
-
2342518106
-
Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia
-
Kindler T, Breitenbuecher F, Marx A, et al. Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia. Blood. 2004;103:3644-3654.
-
(2004)
Blood
, vol.103
, pp. 3644-3654
-
-
Kindler, T.1
Breitenbuecher, F.2
Marx, A.3
-
25
-
-
0038040669
-
In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C
-
Kindler T, Breitenbuecher F, Kasper S, et al. In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C. Leukemia. 2003;17:999-1009.
-
(2003)
Leukemia
, vol.17
, pp. 999-1009
-
-
Kindler, T.1
Breitenbuecher, F.2
Kasper, S.3
-
26
-
-
11144238397
-
-
National Center for Biotechnology Information, National Library of Medicine. MMDB: Molecular modeling database. http://www.ncbi.nlm.nih.gov/ Structure/MMDB/mmdb.shtml. Accessed February 2004.
-
MMDB: Molecular Modeling Database
-
-
-
27
-
-
1542313903
-
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD transformed hematopoietic cells
-
Bagrintseva K, Schwab R, Kohl TM, et al. Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD transformed hematopoietic cells. Blood. 2004;103: 2266-2275.
-
(2004)
Blood
, vol.103
, pp. 2266-2275
-
-
Bagrintseva, K.1
Schwab, R.2
Kohl, T.M.3
-
28
-
-
0842310394
-
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain
-
Griffith J, Black J, Faerman C, et al. The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol Cell. 2004;13:169-178.
-
(2004)
Mol Cell
, vol.13
, pp. 169-178
-
-
Griffith, J.1
Black, J.2
Faerman, C.3
-
29
-
-
4444350364
-
Identification and characterization of a novel activating mutation of the FLT3 tyrosine kinase in AML
-
Jiang J, Paez JG, Lee JC, et al. Identification and characterization of a novel activating mutation of the FLT3 tyrosine kinase in AML. Blood. 2004; 104:1855-1858.
-
(2004)
Blood
, vol.104
, pp. 1855-1858
-
-
Jiang, J.1
Paez, J.G.2
Lee, J.C.3
-
30
-
-
1242315428
-
Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia
-
Stirewalt DL, Meshinchi S, Kussik SJ, et al. Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia. Br J Haematol. 2004;124:481-484.
-
(2004)
Br J Haematol
, vol.124
, pp. 481-484
-
-
Stirewalt, D.L.1
Meshinchi, S.2
Kussik, S.J.3
-
31
-
-
0034993741
-
Classes of c-KIT activating mutations: Proposed mechanisms of action and implications for disease classification and therapy
-
Longley BJ, Reguera MJ, Ma Y. Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy. Leuk Res. 2001;25:571-576.
-
(2001)
Leuk Res
, vol.25
, pp. 571-576
-
-
Longley, B.J.1
Reguera, M.J.2
Ma, Y.3
-
32
-
-
0242670019
-
PDGFRA activating mutations in gastrointestinal stromal tumors
-
Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299:708-710.
-
(2003)
Science
, vol.299
, pp. 708-710
-
-
Heinrich, M.C.1
Corless, C.L.2
Duensing, A.3
-
33
-
-
10744230697
-
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
-
Ley TJ, Minx PJ, Walter MJ, et al. A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proc Natl Acad Sci U S A. 2003; 100:14275-14280.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 14275-14280
-
-
Ley, T.J.1
Minx, P.J.2
Walter, M.J.3
|