Role of PPARs and retinoid X receptors in the regulation of lung maturation and development

PPAR Research

Volumn , Issue , 2007, Pages

  Simon, Dawn M ^a   Mariani, Thomas J ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOIC ACID; RETINOID X RECEPTOR;

DEVELOPMENTAL STAGE; EPITHELIUM CELL; FETUS LUNG MATURATION; HUMAN; LUNG DEVELOPMENT; MAMMAL; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW;

EID: 34447573035     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2007/91240     Document Type: Review

References (100)

1. A. Ijpenberg N. S. Tan L. Gelman In vivo activation of PPAR target genes by RXR homodimers. The EMBO Journal 23 10 2004 2083 2091
2. C. Yu K. Markan K. A. Temple D. Deplewski M. J. Brady R. N. Cohen roncohen@medicine.bsd.uchicago.edu The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor γ transcriptional activity and repress 3T3-L1 adipogenesis. Journal of Biological Chemistry 280 14 2005 13600 13605
3. L. H. Wang X. Y. Yang X. Zhang Transcriptional inactivation of STAT3 by PPARγ suppresses IL-6-responsive multiple myeloma cells. Immunity 20 2004 2 205 218
4. M. Gurnell J. M. Wentworth M. Agostini A dominant-negative peroxisome proliferator-activated receptor γ (PPARγ) mutant is a constitutive repressor and inhibits PPARγ-mediated adipogenesis. Journal of Biological Chemistry 275 8 2000 5754 5759
5. R. A. Daynes daynes.office@path.utah.edu D. C. Jones Emerging roles of PPARs in inflammation and immunity. Nature Reviews Immunology 2 10 2002 748 759
6. M. Schupp J. C. Curtin R. J. Kim A. N. Billin M. A. Lazar A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-γ activity. Molecular Pharmacology 71 2007 1251 1257
7. I. Szatmari A. Pap R. Rühl PPARγ controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. Journal of Experimental Medicine 203 10 2006 2351 2362
8. T. J. Mariani N. Kaminski Gene expression studies in lung development and lung stem cell biology. Current Topics in Developmental Biology 64 2004 57 71
9. T. J. Mariani J. J. Reed S. D. Shapiro Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix. American Journal of Respiratory Cell and Molecular Biology 26 5 2002 541 548
10. D. Warburton dwarburton@chla.usc.edu J. Zhao M. A. Berberich M. Bernfield Molecular embryology of the lung: then, now, and in the future. American Journal of Physiology - Lung Cellular and Molecular Physiology 276 5, part 1 1999 L697 L704
11. D. Warburton dwarburton@chla.usc.edu M. Schwarz D. Tefft G. Flores-Delgado K. D. Anderson W. V. Cardoso The molecular basis of lung morphogenesis. Mechanisms of Development 92 1 2000 55 81
12. J. Motoyama J. Liu R. Mo Q. Ding M. Post C.-C. Hui cchui@sickkids.on.ca Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nature Genetics 20 1 1998 54 57
13. Y. Litingtung L. Lei H. Westphal C. Chiang chin.chiang@ccmail.vanderbilt. edu Sonic hedgehog is essential to foregut development. Nature Genetics 20 1 1998 58 61
14. C. V. Pepicelli P. M. Lewis A. P. McMahon amcmahon@biosun.harvard.edu Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Current Biology 8 19 1998 1083 1086
15. K. Peters S. Werner X. Liao S. Wert J. A. Whitsett L. Williams Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. The EMBO Journal 13 14 1994 3296 3301
16. S. Bellusci J. Grindley H. Emoto N. Itoh B. L. M. Hogan brigid.hogan@mcmail.vanderbilt.edu Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124 23 1997 4867 4878
17. D. Sutherland C. Samakovlis M. A. Krasnow branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. Cell 87 6 1996 1091 1101
18. W. Y. Park B. Miranda D. Lebeche G. Hashimoto W. V. Cardoso FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Developmental Biology 201 2 1998 125 134
19. H. Min D. M. Danilenko S. A. Scully Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes and Development 12 20 1998 3156 3161
20. K. Sekine H. Ohuchi M. Fujiwara Fgf10 is essential for limb and lung formation. Nature Genetics 21 1 1999 138 141
21. S. Bellusci R. Henderson G. Winnier T. Oikawa B. L. M. Hogan Evidence from normal expression and targeted misexpression that bone morphogenetic protein-4 (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 122 6 1996 1693 1702
22. M. Weaver N. R. Dunn B. L. M. Hogan brigid.hogan@mcmail.vanderbilt.edu Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development 127 12 2000 2695 2704
23. J. D. Tefft L. Matt S. Smith Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis. Current Biology 9 4 1999 219 222
24. M. Weaver brigid.hogan@mcmail.vanderbilt.edu J. M. Yingling N. R. Dunn S. Bellusci B. L. M. Hogan Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. Development 126 18 1999 4005 4015
25. M. Roth-Kleiner M. Post martin.post@sickkids.ca Genetic control of lung development. Biology of the Neonate 84 1 2003 83 88
26. J. M. Shannon john.shannon@chmcc.org B. A. Hyatt Epithelial-mesenchymal interactions in the developing lung. Annual Review of Physiology 66 2004 625 645
27. W. V. Cardoso Lung morphogenesis revisited: old facts, current ideas. Developmental Dynamics 219 2 2000 121 130
28. H. Wan Y. Xu M. Ikegami Foxa2 is required for transition to air breathing at birth. Proceedings of the National Academy of Sciences of the United States of America 101 40 2004 14449 14454
29. P. C. Martis J. A. Whitsett Y. Xu A.-K. T. Perl H. Wan M. Ikegami machiko.ikegami@cchmc.org C/EBPα is required for lung maturation at birth. Development 133 6 2006 1155 1164
30. V. Davé davev0@cchmc.org T. Childs Y. Xu Calcineurin/Nfat signaling is required for perinatal lung maturation and function. Journal of Clinical Investigation 116 10 2006 2597 2609
31. P. H. Burri Fetal and postnatal development of the lung. Annual Review of Physiology 46 1984 617 628
32. H. Boström K. Willetts M. Pekny PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 85 6 1996 863 873
33. M. Weinstein X. Xu K. Ohyama C.-X. Deng ChuxiaD@bdg10.niddk.nih.gov FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 125 18 1998 3615 3623
34. T. J. Mariani Regulation of alveogenesis by reciprocal proximodistal FGF and retinoic acid signaling. American Journal of Respiratory Cell and Molecular Biology 31 2004 2 S52 S57
35. Y. Kasahara R. M. Tuder L. Taraseviciene-Stewart Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. Journal of Clinical Investigation 106 11 2000 1311 1319
36. X. Zeng S. E. Wert R. Federici K. G. Peters J. A. Whitsett WHITJO@CHMCC.ORG VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo. Developmental Dynamics 211 3 1998 215 227
37. H.-P. Gerber K. J. Hillan A. M. Ryan VEGF is required for growth and survival in neonatal mice. Development 126 6 1999 1149 1159
38. B. Thébaud bthebaud@ualberta.ca F. Ladha E. D. Michelakis Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation 112 16 2005 2477 2486
39. V. Compernolle K. Brusselmans T. Acker Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nature Medicine 8 7 2002 702 710
40. E. A. Boyden D. H. Tompsett The changing patterns in the developing lungs of infants. Acta Anatomica 61 2 1965 164 192
41. D. Massaro N. Teich S. Maxwell G. D. Massaro P. Whitney Postnatal development of alveoli. Regulation and evidence for a critical period in rats. Journal of Clinical Investigation 76 4 1985 1297 1305
42. K. Kida W. M. Thurlbeck The effects of β-aminopropionitrile on the growing rat lung. American Journal of Pathology 101 3 1980 693 710
43. A. Nagai M. Katayama W. M. Thurlbeck R. Matsui S. Yasui K. Konno Effect of indomethacin on lung development in postnatal rats: possible role of prostaglandin in alveolar formation. American Journal of Physiology - Lung Cellular and Molecular Physiology 268 1, part 1 1995 L56 L62
44. Y. Kimura kimuyu@patholo2.med.tohoku.ac.jp T. Suzuki C. Kaneko Retinoid receptors in the developing human lung. Clinical Science 103 6 2002 613 621
45. P. Dolle V. Fraulob P. Kastner P. Chambon Developmental expression of murine retinoid X receptor (RXR) genes. Mechanisms of Development 45 2 1994 91 104
46. S. Malpel C. Mendelsohn W. V. Cardoso wcardoso@bupula.bu.edu Regulation of retinoic acid signaling during lung morphogenesis. Development 127 14 2000 3057 3067
47. P. Dolle E. Ruberte P. Leroy G. Morriss-Kay P. Chambon Retinoic acid receptors and cellular retinoid binding proteins - I: a systematic study of their differential pattern of transcription during mouse organogenesis. Development 110 4 1990 1133 1151
48. C. Wongtrakool S. Malpel J. Gorenstein Down-regulation of retinoic acid receptor α signaling is required for sacculation and type I cell formation in the developing lung. Journal of Biological Chemistry 278 47 2003 46911 46918
49. M. Mark N. B. Ghyselinck P. Chambon chambon@igbmc.u-strasbg.fr Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annual Review of Pharmacology and Toxicology 46 2006 451 480
50. P. Germain germain@titus.u-strasbg.fr P. Chambon G. Eichele International union of pharmacology. LX. Retinoic acid receptors. Pharmacological Reviews 58 4 2006 712 725
51. P. Germain germain@titus.u-strasbg.fr P. Chambon G. Eichele International union of pharmacology. LXIII. Retinoid X receptors. Pharmacological Reviews 58 4 2006 760 772
52. P. Kastner J. M. Grondona M. Mark Genetic analysis of RXRα developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 78 6 1994 987 1003
53. H. M. Sucov E. Dyson C. L. Gumeringer J. Price K. R. Chien R. M. Evans RXR α mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes and Development 8 9 1994 1007 1018
54. M. Li H. Chiba X. Warot RXRα ablation in skin keratinocytes results in alopecia and epidermal alterations. Development 128 5 2001 675 688
55. M. Li A. K. Indra X. Warot Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis. Nature 407 6804 2000 633 636
56. D. Metzger M. Li P. Chambon Targeted somatic mutagenesis in the mouse epidermis. Methods in Molecular Biology 289 2005 329 340
57. Y.-J. Y. Wan D. An Y. Cai Hepatocyte-specific mutation establishes retinoid X receptor α as a heterodimeric integrator of multiple physiological processes in the liver. Molecular and Cellular Biology 20 12 2000 4436 4444
58. P. Kastner M. Mark M. Leid Abnormal spermatogenesis in RXRβ mutant mice. Genes and Development 10 1 1996 80 92
59. W. Krezel V. Dupé M. Mark A. Dierich P. Kastner P. Chambon RXR γ null mice are apparently normal and compound RXR α+/-/RXR β-/-/RXR γ-/- mutant mice are viable. Proceedings of the National Academy of Sciences of the United States of America 93 17 1996 9010 9014
60. N. S. Brown A. Smart V. Sharma Thyroid hormone resistance and increased metabolic rate in the RXR-γ- deficient mouse. Journal of Clinical Investigation 106 1 2000 73 79
61. G. D. Massaro D. Massaro W. Y. Chan Retinoic acid receptor-β: an endogenous inhibitor of the perinatal formation of pulmonary alveoli. Physiological Genomics 4 1 2000 51 57
62. S. McGowan stephen-mcgowan@uiowa.edu S. K. Jackson M. Jenkins-Moore H.-H. Dai P. Chambon J. M. Snyder Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. American Journal of Respiratory Cell and Molecular Biology 23 2 2000 162 167
63. T. J. Desai F. Chen J. Lü Distinct roles for retinoic acid receptors α and β in early lung morphogenesis. Developmental Biology 291 1 2006 12 24
64. R. Mollard N. B. Ghyselinck O. Wendling P. Chambon M. Mark Stage-dependent responses of the developing lung to retinoic acid signaling. International Journal of Developmental Biology 44 5 2000 457 462
65. D. Lohnes P. Kastner A. Dierich M. Mark M. LeMeur P. Chambon Function of retinoic acid receptor γ in the mouse. Cell 73 1993 4 643 658
66. E. Ruberte P. Dolle A. Krust A. Zelent G. Morriss-Kay P. Chambon Specific spatial and temporal distribution of retinoic acid receptor γ transcripts during mouse embryogenesis. Development 108 2 1990 213 222
67. J. Luo P. Pasceri R. A. Conlon J. Rossant V. Giguere Mice lacking all isoforms of retinoic acid receptor β develop normally and are susceptible to the teratogenic effects of retinoic acid. Mechanisms of Development 53 1 1995 61 71
68. N. B. Ghyselinck V. Dupé A. Dierich Role of the retinoic acid receptor β (RARβ) during mouse development. International Journal of Developmental Biology 41 3 1997 425 447
69. C. Mendelsohn D. Lohnes D. Decimo Function of the retinoic acid receptors (RARs) during development (II). multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120 10 1994 2749 2771
70. P. Kastner M. Mark N. Ghyselinck Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Development 124 2 1997 313 326
71. M. Maden malcolm.maden@kc1.ac.uk The role of retinoic acid in embryonic and post-embryonic development. Proceedings of the Nutrition Society 59 1 2000 65 73
72. G. D. Massaro D. Massaro Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. American Journal of Physiology - Lung Cellular and Molecular Physiology 270 2, part 1 1996 L305 L310
73. G. C. Massaro D. Massaro Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nature Medicine 3 6 1997 675 677
74. H. Matsuura H. Adachi R. C. Smart X. Xu J. Arata A. M. Jetten jetten@niehs.nih.gov Correlation between expression of peroxisome proliferator-activated receptor β and squamous differentiation in epidermal and tracheobronchial epithelial cells. Molecular and Cellular Endocrinology 147 1-2 1999 85 92
75. J. Berger D. E. Moller The mechanisms of action of PPARs. Annual Review of Medicine 53 2002 409 435
76. L. Benayoun S. Letuve A. Druilhe Regulation of peroxisome proliferator-activated receptor γ expression in human asthmatic airways: relationship with proliferation, apoptosis, and airway remodeling. American Journal of Respiratory and Critical Care Medicine 164 8, part 1 2001 1487 1494
77. A. C. Wang X. Dai B. Luu D. J. Conrad Peroxisome proliferator-activated receptor-γ regulates airway epithelial cell activation. American Journal of Respiratory Cell Molecular Biology 24 2001 6 688 693
78. H. J. Patel h.j.patel@ic.ac.uk M. G. Belvisi D. Bishop-Bailey M. H. Yacoub J. A. Mitchell Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. Journal of Immunology 170 5 2003 2663 2669
79. D. S. Calnek dcalnek@hotmail.com L. Mazzella S. Roser J. Roman C. M. Hart Peroxisome proliferator-activated receptor γ ligands increase release of nitric oxide from endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 23 1 2003 52 57
80. G. Chinetti S. Griglio M. Antonucci Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. Journal of Biological Chemistry 273 40 1998 25573 25580
81. G. Woerly K. Honda M. Loyens Peroxisome proliferator-activated receptors α and γ down-regulate allergic inflammation and eosinophil activation. Journal of Experimental Medicine 198 3 2003 411 421
82. P. Gosset A.-S. Charbonnier P. Delerive Peroxisome proliferator-activated receptor γ activators affect the maturation of human monocyte-derived dendritic cells. European Journal of Immunology 31 10 2001 2857 2865
83. A.-M. Barlier-Mur B. Chailley-Heu C. Pinteur A. Henrion-Caude C. Delacourt J. R. Bourbon Jacques.Bourbon@creteil.inserm.fr Maturational factors modulate transcription factors CCAAT/enhancer-binding proteins α, β, δ, and peroxisome proliferator-activated receptor-γ in fetal rat lung epithelial cells. American Journal of Respiratory Cell and Molecular Biology 29 5 2003 620 626
84. L. F. Michael M. A. Lazar C. R. Mendelson cmende@biochem.swmed.edu Peroxisome proliferator-activated receptor γ1 expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumonocytes. Endocrinology 138 9 1997 3695 3703
85. D. M. Simon M. C. Arikan S. Srisuma Epithelial cell PPARγ contributes to normal lung maturation. FASEB j 20 9 2006 1507 1509
86. J. Zhang M. Fu T. Cui Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America 101 29 2004 10703 10708
87. Y. Barak M. C. Nelson E. S. Ong PPARγ is required for placental, cardiac, and adipose tissue development. Molecular Cell 4 4 1999 585 595
88. S. Z. Duan C. Y. Ivashchenko S. E. Whitesall Hypotension, lipodystrophy, and insulin resistance in generalized PPARγ-deficient mice rescued from embryonic lethality. Journal of Clinical Investigation 117 3 2007 812 822
89. P. Shankaranarayanan S. Nigam nigam@zedat.fu-berlin.de IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor γ transcription factor. Journal of Immunology 170 2 2003 887 894
90. E. Mueller P. Sarraf P. Tontonoz Terminal differentiation of human breast cancer through PPARγ Molecular Cell 1 3 1998 465 470
91. P. Sarraf E. Mueller D. Jones Differentiation and reversal of malignant changes in colon cancer through PPARγ Nature Medicine 4 9 1998 1046 1052
92. P. Tontonoz S. Singer B. M. Forman Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proceedings of the National Academy of Sciences of the United States of America 94 1 1997 237 241
93. Y. Bren-Mattison V. van Putten D. Chan R. Winn M. W. Geraci R. A. Nemenoff raphael.nemenoff@uchsc.edu Peroxisome proliferator-activated receptor-γ (PPARγ) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC). Oncogene 24 8 2005 1412 1422
94. T.-H. Chang E. Szabo szaboe@mail.nih.gov Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor γ in non-small cell lung cancer. Cancer Research 60 4 2000 1129 1138
95. L. Yang D. Yan C. Yan H. Du Peroxisome proliferator-activated receptor γ and ligands inhibit surfactant protein B gene expression in the lung. Journal of Biological Chemistry 278 2003 36841 36847
96. M. Ricote A. C. Li T. M. Willson C. J. Kelly C. K. Glass cglass@ucsd.edu The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391 6662 1998 79 82
97. H. Hammad h.hammad@erasmusmc.nl H. J. de Heer T. Soullié Activation of peroxisome proliferator-activated receptor-γ in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma. American Journal of Pathology 164 1 2004 263 271
98. R. B. Clark rclark@nso2.uchc.edu D. Bishop-Bailey T. Estrada-Hernandez T. Hla L. Puddington S. J. Padula The nuclear receptor PPARγ and immunoregulation: PPARγ mediates inhibition of helper T cell responses. Journal of Immunology 164 3 2000 1364 1371
99. J. Padilla K. Kaur S. G. Harris R. P. Phipps Richard_Phipps@urmc. rochester.edu PPAR-γ-mediated regulation of normal and malignant B lineage cells. Annals of the New York Academy of Sciences 905 2000 97 109
100. T. E. Akiyama S. Sakai G. Lambert Conditional disruption of the peroxisome proliferator-activated receptor γ gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Molecular and Cellular Biology 22 8 2002 2607 2619