The role of retinoic acid in embryonic and post-embryonic development

Proceedings of the Nutrition Society

Volumn 59, Issue 1, 2000, Pages 65-73

  Maden, Malcolm ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Development; Regeneration; Retinoic acid; Retinoids

Indexed keywords

ALCOHOL DEHYDROGENASE; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; RETINOL; RETINOL DEHYDROGENASE; TRANSCRIPTION FACTOR;

CONFERENCE PAPER; EMBRYO DEVELOPMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NONHUMAN; REGENERATION;

ANIMALIA;

EID: 0034069728     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0029665100000082     Document Type: Conference Paper

References (97)

1. Abu-Abed SS, Beckett BR, Chiba H, Chithalen JV, Jones G, Metzger D, Chambon P & Petkovich M (1998) Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. Journal of Biological Chemistry 273, 2409-2415.
2. Ang HL & Duester G (1997) Initiation of retinoid signalling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis. Developmental Dynamics 208, 536-543.
3. Antipatis C, Achworth CJ, Grant G, Lea RG, Hay SM & Rees WD (1998) Effects of maternal vitamin A status on fetal heart and lung: changes in expression of key developmental genes. American Journal of Physiology 275, L1184-L1191.
4. Balkan W, Colbert M, Bock C & Linney E (1992) Transgenic indicator mice for studying activated retinoic acid receptors during development. Proceedings of the National Academy of Sciences USA 89, 3347-3351.
5. Bavik C, Ward SJ & Ong DE (1997) Identification of a mechanism to localize generation of retinoic acid in rat embryos. Mechanisms of Development 69, 155-167.
6. Blomhoff R (1994) Introduction: overview of vitamin A metabolism and function. In Vitamin A in Health and Disease, pp. 1-35 [R Blomhoff, editor]. New York: Marcel Dekker Inc.
7. Colbert MC, Linney E & LaMantia AS (1993) Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development. Proceedings of the National Academy of Sciences USA 90, 6572-6576.
8. Costaridis P, Horton C, Zeitlinger J, Holder N & Maden M (1996) Endogenous retinoids in the zebrafish embryo and adult. Developmental Dynamics 205, 41-51.
9. Creech-Kraft J, Schuh T, Juchau MR & Kimelman D (1994) Temporal distribution, localization and metabolism of all-trans-retinol, didehydroretinol and all-trans-retinal during Xenopus development. Biochemical Journal 301, 111-119.
10. de Roos K, Sonneveld E, Compaan B, ten Berge D, Durston AJ & van der Saag PT (1999) Expression of retinoic acid 4-hydroxylase (CYP26) during mouse and Xenopus laevis embryogenesis. Mechanisms of Development 82, 205-211.
11. Dersch H & Zile MH (1993) Induction of normal cardiovascular development in the vitamin A-deprived quail embryo by natural retinoids. Developmental Biology 160, 424-433.
12. Dickman ED, Thaller C & Smith SM (1997) Temporally-regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects. Development 124, 3111-3121.
13. Dolle P, Fraulob V, Kastner P & Chambon P (1994) Developmental expression of murine retinoid X receptor (RXR) genes. Mechanisms of Development 45, 91-104.
14. Dong D & Zile MH (1995) Endogenous retinoids in the early avian embryo. Biochemical and Biophysical Research Communications 217, 1026-1031.
15. Duester G (1996) Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signalling by activation of retinoic acid synthesis. Biochemistry 35, 12221-12227.
16. Durston AJ, Timmermans JPM, Hage WJ, Hendricks HFJ, de Vries NJ, Heideveld M & Nieuwkoop PD (1989) Retinoic acid causes an anteroposterior transformation in the developing nervous system. Nature 340, 140-144.
17. Fantel AG, Shepard TH, Newell-Morris LL & Moffett BC (1977) Teratogenic effects of retinoic acid in pigtail monkeys (Macaca nemestrina). Teratology 15, 65-72.
18. Fujii H, Sato T, Kaneko S, Gotoh O, Fujii-Kuriyama Y, Osawa K, Kato S & Hamada H (1997) Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO Journal 16, 4163-4173.
19. Godbout R, Packer M, Poppema S & Dabbath L (1996) Localization of cytosolic aldehyde dehydrogenase in the developing chick retina: in situ hydridisation and immunohistochemical analyses. Developmental Dynamics 205, 319-331.
20. Hale F (1933) Pigs born without eye balls. Journal of Heredity 24, 105-106.
21. Heine UI, Roberts AB, Munoz EF, Roche NS & Sporn MB (1985) Effects of retinoid deficiency on the development of the heart and vascular system of the quail embryo. Cell Pathology 50, 135-152.
22. Hollemann T, Chen Y, Grunz H & Pieler T (1998) Regionalized metabolic activity establishes boundaries of retinoic acid signalling. EMBO Journal 17, 7361-7372.
23. Horton C & Maden M (1995) Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo. Developmental Dynamics 202, 312-323.
24. Kalter H & Warkany J (1959) Experimental production of congenital malformations in mammals by metabolic procedure. Physiology Reviews 39, 69-115.
25. Kastner P, Chambon P & Leid M (1994a) Role of nuclear retinoic acid receptors in the regulation of gene expression. In Vitamin A in Health and Disease, pp. 189-238 [R Blomhoff, editor]. New York: Marcel Dekker Inc.
26. Kastner P, Grondona JM, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch J-L, Dolle P & Chambon P (1994b) Genetic analysis of RXRa developmental function: convergence of RXR and RAR signalling pathways in heart and eye morphogenesis. Cell 78, 987-1003.
27. Kastner P, Mark M & Chambon P (1995) Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83, 859-869.
28. Kastner P, Mark M, Ghyselinck N, Krezel W, Dupe V, Grondona JM & Chambon P (1997) Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Development 124, 313-326.
29. Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Decimo D, Krezel W, Dierich A & Chambon P (1996) Abnormal spermatogenesis in RXRβ mutant mice. Genes and Development 10, 80-92.
30. Kliewer SA, Umesono K, Evans RM & Mangelsdorf DJ (1994) The retinoid X receptors: modulators of multiple hormonal signaling pathways. In Vitamin A in Health and Disease, pp. 239-255 [R Blomhoff, editor]. New York: Marcel Dekker Inc.
31. Knudsen PA (1966) Congenital malformations of lower incisors and molars in exencephalic mouse embryos, induced by hypervitaminosis A. Acta Odontologica Scandinavica 24, 55-71.
32. Kochhar DM (1973) Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid. Teratology 7, 289-298.
33. LaMantia AS, Colbert MC & Linney E (1993) Retinoic acid induction and regional differentiation prefigure olfactory pathway formation in the mammalian forebrain. Neuron 10, 1035-1048.
34. Lammer EJ, Chen DT, Hoar RM, Agnish AD, Benke PJ, Braun JT, Curry CJ, Fernhoff PM, Grix AW, Lott IT, Richard JM & Sun SC (1985) Retinoic acid embryopathy. New England Journal of Medicine 313, 837-841.
35. Lefebvre PP, Malgrange B, Staecker H, Moonen G & van de Water TR (1993) Retinoic acid stimulates regeneration of mammalian auditory hair cells. Science 260, 692-695.
36. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M & Chambon P (1993) Function of retinoic acid in the mouse. Cell 73, 643-658.
37. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M & Chambon P (1993) High postnatal lethality and testis degeneration in retinoic acid receptor a mutant mice. Proceedings of the National Academy of Sciences USA 90, 7225-7229.
38. McCaffery P & Drager UC (1994) Hot spots of retinoic acid synthesis in the developing spinal cord. Proceedings of the National Academy of Sciences USA 91, 7194-7197.
39. McCaffery P, Lee M-O, Wagner MA, Sladek NE & Drager U (1992) Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina. Development 115, 371-382.
40. McCaffery P, Posch KC, Napoli JL, Gudas L & Drager UC (1993) Changing patterns of the retinoic acid system in the developing retina. Developmental Biology 158, 390-399.
41. McCaffery P, Tempst P, Lara G & Drager UC (1991) Aldehyde dehydrogenase is a positional marker in the retina. Development 112, 693-702.
42. McCaffery P, Wagner E, O'Neil J, Petkovich M & Drager UC (1999) Dorsal and ventral territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. Mechanisms of Development 82, 119-130.
43. Maden M (1982) Vitamin A and pattern formation in the regenerating limb. Nature 295, 672-675.
44. Maden M (1983) The effect of vitamin A on limb regeneration in Rana temporaria. Developmental Biology 98, 409-416.
45. Maden M (1993) The homeotic transformation of tails into limbs in Rana temporaria by retinoids. Developmental Biology 159, 379-391.
46. Maden M (1998a) Retinoids as endogenous components of the regenerating limb and tail. Wound Repair and Regeneration 6, 358-365.
47. Maden M (1998b) Retinoids in neural development. In Retinoids, pp. 399-442 [H Nau and WS Blaner, editors]. Berlin: Springer-Verlag:.
48. Maden M, Gale E, Kostetskii I & Zile M (1996) Vitamin A-deficient quail embryos have half a hindbrain and other neural defects. Current Biology 6, 417-426.
49. Maden M, Gale E & Zile M (1998a) The role of vitamin A in the development of the central nervous system. Journal of Nutrition 128, 471S-475S.
50. Maden M, Sonneveld E, van der Saag PT & Gale E (1998b) The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms. Development 125, 4133-4144.
51. Mangelsdorf DJ, Borgmeyer U, Heyman RA, Khou JY, Ong ES, Oro AE, Kakizuka A & Evans RM (1992) Characterisation of three RXR genes that mediate the action of 9-cis retinoic acid. Genes and Development 6, 329-344.
52. Mascrez B, Mark M, Dierich A, Ghyselinck NB, Kastner P & Chambon P (1998) The RXRa ligand-dependent activation function 2 (AF02) is important for mouse development. Development 125, 4691-4707.
53. Massaro GDC & Massaro D (1997) Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nature Medicine 3, 675-677.
54. Mertz JR, Shang E, Piantedosi R, Wei S, Wolgemuth DJ & Blaner WS (1997) Identification and characterization of a stereospecific human enzyme that catalyses 9-cis-retinol oxidation. Journal of Biological Chemistry 272, 11744-11749.
55. Mohanty-Hejmadi P, Dutta SK & Mahapatra P (1992) Limbs generated at site of tail amputation in marbled balloon frog after vitamin A treatment. Nature 355, 352-353.
56. Morriss-Kay GM & Sokolova N (1996) Embryonic development and pattern formation. FASEB Journal 10, 961-968.
57. Moss JB, Xavier-Neto J, Shapiro MD, Nayeem SM, McCaffery P, Drager UC & Rosenthal N (1998) Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. Developmental Biology 199, 55-71.
58. Muto K, Noji S, Nohno T, Koyama E, Myokai F, Nishijima K, Saito T & Taniguchi S (1991) Involvement of retinoic acid and its receptor β in differentiation of motoneurons in chick spinal cord. Neuroscience Letters 129, 39-42.
59. Napoli JL (1996) Retinoic acid biosynthesis and metabolism. FASEB Journal 10, 993-1001.
60. Niazi IA & Ratnasamy CS (1984) Regeneration of whole limbs in toad tadpoles treated with retinol palmitate after the wound-healing stage. Journal of Experimental Zoology 230, 501-505.
61. Niazi IA & Saxena S (1978) Abnormal hind limb regeneration in tadpoles of the toad, Bufo andersoni, exposed to excess vitamin A. Folia Biologica (Krakow) 26, 1-8.
62. Niederreither K, McCaffery P, Drager UC, Chambon P & Dolle P (1997) Restricted expression and retinoic acid-induced down-regulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mechanisms of Development 62, 67-78.
63. Niederreither K, Subbarayan V, Dolle P & Chambon P (1999) Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nature Genetics 21, 444-448.
64. Pecorino L, Entwistle A & Brockes JP (1996) Activation of a single retinoic acid receptor isoform mediates proximodistal respecification. Current Biology 6, 563-569.
65. Pecorino LT, Lo DC & Brockes JP (1994) Isoform-specific induction of a retinoid-responsive antigen after biolistic transfection of chimaeric retinoic acid/thyroid hormone receptors into a regenerating limb. Development 120, 325-333.
66. Pijnappel WWM, Hendricks HFJ, Folkers GE, van den Brink CE, Dekker EJ, Edelenbosch C, van der Saag PT & Durston AJ (1993) The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification. Nature 366, 340-344.
67. Ragsdale CW, Gates PB & Brockes JP (1992a) Identification and expression pattern of a second isoform of the newt alpha retinoic acid receptor. Nucleic Acid Research 20, 5851.
68. Ragsdale CW, Gates PB, Hill DS & Brockes JP (1992b) Delta retinoic acid receptor isoform δ1 is distinguished by its exceptional N-terminal sequence and abundance in the limb regeneration blastema. Mechanisms of Development 40, 99-112.
69. Ragsdale CW, Petkovich M, Gates PB, Chambon P & Brockes JP (1989) Identification of a novel retinoic acid receptor in regenerating tissues of the newt. Nature 341, 654-657.
70. Reynolds K, Mezey E & Zimmer A (1991) Activity of the β-retinoic acid receptor promoter in transgenic mice. Mechanisms of Development 36, 15-29.
71. Romert A, Tuvendal P, Simon A, Dencker L & Eriksson U (1998) The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid. Proceedings of the National Academy of Sciences USA 95, 4404-4409.
72. Rosa FW, Wilk AL & Kelsey FO (1986) Teratogen update: vitamin A congeners. Teratology 33, 355-364.
73. Ross CA & Hammerling UG (1994) Retinoids and the immune system. In The Retinoids, pp. 521-543 [MB Sporn, AB Roberts and DS Goodman, editors]. New York: Raven Press.
74. Rossant J, Zirngibl R, Cado D, Shago M & Giguere V (1991) Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes and Development 5, 1333-1344.
75. Ruberte E, Dolle P, Chambon P & Morriss-Kay G (1991) Retinoic acid receptors and cellular retinoid binding proteins. II Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111, 45-60.
76. Ruberte E, Dolle P, Krust A, Zebent A, Morriss-Kay G & Chambon P (1990) Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis. Development 108, 213-222.
77. Ruberte E, Friedrich V, Chambon P & Morriss-Kay G (1993) Retinoic acid receptors and cellular retinoid binding proteins. III Their differential transcript distribution during mouse nervous system development. Development 118, 267-282.
78. Satre A & Kochhar DM (1989) Elevations in the endogenous levels of the putative morphogen retinoic acid in embryonic mouse limb-buds associated with limb dysmorphogenesis. Developmental Biology 133, 529-536.
79. Schilthuis JG, Gann AAF & Brockes JP (1993) Chimeric retinoic acid/thyroid hormone receptors implicate RAR α1 as mediating growth inhibition by retinoic acid. EMBO Journal 12, 3459-3466.
80. Scott WJ, Walter R, Tzimas G, Sass JO, Nau H & Collins MD (1994) Endogenous status of retinoids and their cytosolic binding proteins and limb buds of chick vs mouse embryos. Developmental Biology 165, 397-409.
81. Shen S, van den Brink CE, Kruijer W & van der Saag PT (1992) Embryonic stem cells stably transfected with mRARb2-lacZ exhibit specific expression in chimeric embryos. International Journal of Developmental Biology 36, 465-476.
82. Shenfelt RE (1972) Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment. Teratology 5, 103-118.
83. Sockanathan S & Jessell TM (1998) Motor neuron-derived retinoid signalling specifies the subtype identity of spinal motor neurons. Cell 94, 503-514.
84. Sonneveld E, van den Brink CE, Tertoolen LGJ, van der Burg B & van der Saag PT (1999) Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells. Developmental Biology 213, 390-404.
85. Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR & Evans RM (1994) RXRa mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes and Development 8, 1007-1018.
86. Thaller C '& Eichele G (1990) Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud. Nature 345, 815-819.
87. Thompson JN, Howell JM, Pitt GAJ & McLaughlin CI (1969) The biological activity of retinoic acid in the domestic fowl and the effects of vitamin A deficiency on the chick embryo. British Journal of Nutrition 23, 471-490.
88. Tyson JE, Wright LL, Oh W, Kennedy KA, Mele L, Ehrenkranz RA, Stoll BJ, Lemons JA, Stevenson DK, Bauer CR, Korones SB & Faranoff AA (1999) Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. New England Journal of Medicine 340, 1962-1968.
89. Underwood BA (1984) Vitamin A in animal and human nutrition. In The Retinoids, pp. 281-392 [MB Sporn, AB Roberts and DS Goodman, editors]. New York: Academic Press.
90. Viviano CM, Horton C, Maden M & Brockes JP (1995) Synthesis and release of 9-cis retinoic acid by the urodele wound epidermis. Development 121, 3753-3762.
91. Vonesch J-L, Nakashatri H, Philippe M, Chambon P & Dolle P (1994) Stage and tissue-specific expression of the alcohol dehydrogenase 1 (adh-1) gene during mouse development. Developmental Dynamics 199, 199-213.
92. Wagner M, Han B & Jessell TM (1992) Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay. Development 116, 55-66.
93. White JA, Beckett-Jones B, Guo Y-D, Dilworth FJ, Bonasoro J, Jones G & Petkovich M (1997) cDNA cloning of human retinoic acid-metabolizing enzyme (hp450RAI) identifies a novel family of cytochromes P450 (CYP26). Journal of Biological Chemistry 272, 18538-18541.
94. White JA, Guo Y-D, Baetz K, Beckett-Jones B, Bonasoro J, Hsu E, Dilworth FJ, Jones G & Petkovich M (1996) Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase. Journal of Biological Chemistry 271, 29922-29927.
95. White JC, Shankar VN, Highland M, Epstein ML, DeLuca HF & Clagett-Dame M (1998) Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid. Proceedings of the National Academy of Sciences USA 95, 13459-13464.
96. Wolbach SB & Howe PR (1925) Tissue changes following deprivation of fat soluble A vitamin. Journal of Experimental Medicine 42, 753-777.
97. Zhao D, McCaffery P, Ivins KJ, Neve RL, Hogan P, Chin WW & Drager UC (1996) Molecular identification of a major retinoic acid-synthesising enzyme, a retinaldehyde-specific dehydrogenase. European Journal of Biochemistry 240, 15-22.