Thyroid hormone resistance and increased metabolic rate in the RXR-γ- deficient mouse

Journal of Clinical Investigation

Volumn 106, Issue 1, 2000, Pages 73-79

  Brown, Nicole S ^a   Smart, Alexandra ^a   Sharma, Vibha ^a   Brinkmeier, Michelle L ^b   Greenlee, Lauren ^b   Camper, Sally A ^b   Jensen, Dalan R ^a   Eckel, Robert H ^a   Krezel, Wojciech ^c   Chambon, Pierre ^d   Haugen, Bryan R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF WALES   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

RETINOID X RECEPTOR;

ANIMAL TISSUE; ARTICLE; FEMALE; FOOD INTAKE; HYPOPHYSIS THYROID SYSTEM; METABOLIC RATE; MOUSE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; THYROID HORMONE RESISTANCE; THYROTROPIN BLOOD LEVEL;

EID: 0033946853     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9422     Document Type: Article

References (26)

1. Simkins, S. 1947. Use of massive doses of vitamin A in the treatment of hyperthyroidism. J. Clin. Endocrinol. Metab. 7:574-585.
2. Shadu, D.P., and Brody, S. 1947. Excess vitamin A ingestion, thyroid size and energy metabolism. Am. J. Physiol. 149:400-404.
3. Morley, J.E., Damassa, D.A., Gordon, J., Pekary, A.E., and Hershman, J.M. 1978. Thyroid function and vitamin A deficiency. Life Sci. 22:1901-1906.
4. Sherman, S.I., et al. 1999. Central hypothyroidism associated with retinoid X receptor selective ligands. N. Engl. J. Med. 340:1075-1079.
5. Haugen, B.R., Brown, N.S., Wood, W.M., Gordon, D.F., and Ridgway, E.C. 1997. The thyrotrope-restricted isoform of the retinoid X receptor (gamma 1) mediates 9-cis retinoic acid suppression of thyrotropin beta promoter activity. Mol. Endocrinol. 11:481-489.
6. Mangelsdorf, D.J., et al. 1992. Characterization of the three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6:329-344.
7. Krezel, W., et al., 1996. RXR gamma null mice are apparently normal and compound RXRa+/-, RXRb-/-, RXRg-/-mutant mice are viable. Proc. Natl. Acad. Sci. USA. 93:9010-9014.
8. Sugawara, A., Yen, P.M., Qi, Y., Lechan, R.M, and Chin, W.W. 1995. Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology. 136:1766-1774.
9. Sanno, N., et al. 1997. Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas. Neuroendocrinology. 65:299-306.
10. Gordon, D.F., et al. 1993. Analysis of Pit-1 in regulating mouse TSHbeta promoter activity in thyrotropes. Mol. Cell. Endocrinol. 96:75-84.
11. Ross, D.S., Downing, M.F., Chin, W.W., Kieffer, J.D., and Ridgway, E.C. 1983. Divergent changes in murine pituitary concentration of free alpha and thyrotropin-beta subunits in hypothyroidism and after thyroxine administration. Endocrinology. 112:187-193.
12. Shupnik, M.A., and Ridgway, E.C. 1985. Triiodothyronine rapidly decreases transcription of the thyrotropin subunit genes in thyrotropic tumor explants. Endocrinology. 117:1940-1946.
13. Refetoff, S., DeGroot, L.J., Bernard, B., and DeWind, L.T. 1972. Studies of a sibship with apparent hereditary resistance to the intracellular action of thyroid hormone. Metabolism. 21:723-756.
14. Krezel, W., Kastner, P., and Chambon, P. 1999. Differential expression of retinoid receptors in the adult mouse central nervous system. Neuroscience. 89:1291-1300.
15. Wood, W.M., Kao, M.Y., Gordon, D.F., and Ridgway, E.C. 1989. Thyroid hormone regulates the mouse thyrotropin beta subunit gene promoter in transfected primary thyrotropes. J. Biol. Chem 264:14840-14847.
16. Breen, J.J., Hickok, N.J., and Gurr, J.A. 1997. The rat TSH beta gene contains distinct response elements for regulation by retinoids and thyroid hormone. Mol. Cell. Endocrinol. 131:137-146.
17. Wondisford, F.E., et al. 1989. Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon. J. Biol. Chem. 264:14601-14604.
18. Carr, F.E., Kaseem, L.L., and Wong, N.C. 1992. Thyroid hormone inhibits thyrotropin gene expression via a position-independent negative L-triiodothyroinine-responsive element. J. Biol. Chem. 267:18689-18694.
19. Castelein, H., Janssen, A., Declercq, P.E., and Baes, M. 1996. Sequence requirements for high affinity retinoid X receptor-alpha homodimer binding. Mol. Cell. Endocrinol. 119:11-20.
20. Sucov, H.M., et al. 1994. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 8:1007-1018.
21. Kastner, P., et al. 1994. Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell. 78:987-1003.
22. Gruber, P.J., et al. 1996. RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J. Clin. Invest. 98:1332-1343.
23. Kastner, P., et al. 1996. Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev. 10:80-92.
24. Barros, A.C., et al. 1998. Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis. Neuroreport. 9:2933-2937.
25. Breen, J.J., Matsuura, T., Ross, A.C., and Gurr, J.A. 1995. Regulation of thyroid-stimulating hormone beta-subunit and growth hormone messenger ribonucleic acid levels in the rat: effect of vitamin A status. Endocrinology. 136:543-549.
26. Liu, Q., and Linney, E. 1993. The mouse retinoid-X receptor-gamma gene, genomic organization and evidence for functional forms. Mol. Endocrinol. 7:651-658.