Targetting RAS signalling pathways in juvenile myelomonocytic leukemia

Current Drug Targets

Volumn 8, Issue 6, 2007, Pages 715-725

  Flotho, Christian ^a   Kratz, Christian ^a   Niemeyer, Charlotte M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

JMML; Leukemia; MEK; Myeloid; RAF; RAS; Targeted therapy; TOR

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; ANTILEUKEMIC AGENT; ARRY 142886; BISPHOSPHONIC ACID DERIVATIVE; DIPHTHERIA TOXIN; DNA ENZYME; ENZYME; EVEROLIMUS; GENE PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR ANTAGONIST; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; NEUROFIBROMIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN PTPN11; PROTEIN TYROSINE PHOSPHATASE SHP 2; PROTEINASE; PROTEINASE RCE1; RAF PROTEIN; RAPAMYCIN; RAS PROTEIN; SORAFENIB; TACROLIMUS; TEMSIROLIMUS; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLEDRONIC ACID; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG POTENTIATION; DRUG RESPONSE; DRUG SAFETY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; JUVENILE MYELOMONOCYTIC LEUKEMIA; LEUKEMIA RELAPSE; MALIGNANT TRANSFORMATION; MULTIPLE CYCLE TREATMENT; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRENYLATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; UNSPECIFIED SIDE EFFECT; ANIMAL; CHILD; CHRONIC MYELOMONOCYTIC LEUKEMIA; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG EFFECT; METABOLISM; MOUSE; MYELOMONOCYTIC LEUKEMIA; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; CHILD; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; HUMANS; LEUKEMIA, MYELOMONOCYTIC, ACUTE; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MICE; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 34447557903     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007780830773     Document Type: Review

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