Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation [2]

Annals of Oncology

Volumn 16, Issue 8, 2005, Pages 1400-

  Shimada, H ^a   Shima, H ^a   Shimasaki, N ^a   Yoshihara, H ^a   Mori, T ^a   Takahashi, T ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CALCIUM; CYTARABINE; MERCAPTOPURINE; VITAMIN D; ZOLEDRONIC ACID;

CALCIUM BLOOD LEVEL; CASE REPORT; DETERIORATION; DRUG RESPONSE; DRUG TOLERABILITY; FLU LIKE SYNDROME; GENE MUTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HYPOCALCEMIA; HYPOPHOSPHATEMIA; JAPAN; JUVENILE MYELOMONOCYTIC LEUKEMIA; KIDNEY DISEASE; LETTER; LEUKEMIA RELAPSE; LEUKOCYTE COUNT; MALE; PHOSPHATE BLOOD LEVEL; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY FAILURE; SINGLE DRUG DOSE; SPLENOMEGALY;

BONE DENSITY CONSERVATION AGENTS; CHILD, PRESCHOOL; DIPHOSPHONATES; HUMANS; IMIDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MALE; MUTATION; PROTEIN-TYROSINE-PHOSPHATASE; SRC HOMOLOGY DOMAINS; TREATMENT OUTCOME;

EID: 23844478260     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/mdi233     Document Type: Letter

References (5)

1. Ohtsuka Y, Manabe A, Kawasaki H et al. Bisphosphonate zoledronic acid (ZOL) inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia (JMML) cells. Blood 2004; 104: 265b (Abstr).
2. Shimada H, Mori T, Shimasaki N et al. Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia. Leukemia 2004; 18: 1142-1144.
3. Espanol I, Romagosa V, Berlanga J et al. Zoledronate-induced remission of acute panmyelosis with myelofibrosis. Eur J Haematol 2004; 73: 215-218.
4. Chang JT, Green L, Beitz J, Renal failure with the use of zoledronic acid. N Engl J Med 2003; 349: 1676-1679.
5. Hogler W, Yap F, Little D et al. Short-term safety assessment in the use of intravenous zoledronic acid in children. J Pediatr 2004; 145: 701-704.