Genetic aspects of amyloid β-protein fibrillogenesis in Alzheimer's disease

Folia Neuropathologica

Volumn 42, Issue 4, 2004, Pages 235-237

  Kowalska, Anna ^a  

^a INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

Alzheimer's disease; Amyloid ; APP mutations; Fibrillogenesis; Presenilin mutations

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; MONOMER; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; FAMILIAL DISEASE; FIBER; GENE MUTATION; GENETIC ANALYSIS; HUMAN; IN VITRO STUDY; MOLECULAR MECHANICS; OLIGOMERIZATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION;

EID: 12344284943     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Review

References (16)

1. Abraham CR, Selkoe DJ, Potter H (1988) Immunochemical identification of the serine protease inhibitor α 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell, 52: 487-501.
2. Bitan G, Kirkitadze MD, Lomakin A, Vollers SS, Benedek GB, Teplow DB (2003) Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways. Proc Natl Acad Sci USA, 100: 330-335.
3. Dahlgren KN, Manelli AM, Stine WB Jr, Baker LK, Krafft GA, LaDu MJ (2002) Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability. J Biol Chem, 277: 32046-32053.
4. Enya M, Morishima-Kawashima M, Yoshimura M, Shinkai Y, Kusui K, Khan K, Games D, Schenk D, Sugihara S, Yamaguchi H, Ihara Y (1999) Appearance of sodium dodecyl sulfate-stable amyloid β-protein (Aβ) dimer in the cortex during aging. Am J Pathol, 154: 271-279.
5. Harper JD, Wong SS, Lieber CM, Lansbury PT (1997) Observation of metastable Aβ amyloid protofibrils by atomic force microscopy. Chem Biol, 4: 119-125.
6. Kirkitadze MD, Condron MM, Teplow DB (2001) Identification and characterization of key kinetic intermediates in amyloid β -protein fibrillogenesis. J Mol Biol, 312: 1103-1119.
7. Kowalska A (2003) Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease. Folia Neuropathol, 41: 35-40.
8. Kowalska A (2004) Genetic basis of neurodegeneration in familial Alzheimer's disease. Pol J Pharmacology, 56.
9. Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL (1998) Diffusible, non-fibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA, 95: 6448-6453.
10. LeVine H 3-rd (1995) Soluble multitimeric Alzheimer β (1-40) pre-amyloid complexes in dilute solution. Neurobiol Aging, 16: 755-764.
11. Ma J, Yee A, Brewer HB, Das S, Potter H (1994) Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature, 372: 92-94.
12. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW (1993) Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci, 13: 1676-1687.
13. Saido TC (1998) Alzheimer's disease as proteolytic disorder: Anabolism and catabolism of β-amyloid. Neurobiol Aging, 19: S69-S75.
14. Terry RD, Gonatas NK, Weiss M (1964) The ultrastructure of the cerebral cortex in Alzheimer's disease. Am Neurol Assoc, 89: 12.
15. Van Nostrand WE, Melchor JP, Cho HS, Greenberg SM, Rebeck GW (2001) Pathogenic effects of D23N Iowa mutant amyloid beta-protein. J Biol Chem, 276: 32860-32866.
16. Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB (1997) Amyloid β-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem, 272: 22364-22372.