A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects

Journal of Biological Chemistry

Volumn 279, Issue 39, 2004, Pages 41124-41130

  Östberg, Tove ^a   Svensson, Stefan ^b   Selén, Göran ^c   Uppenberg, Jonas ^b   Thor, Markus ^c   Sundbom, Maj ^c   Sydow Bäckman, Mona ^c   Gustavsson, Anna Lena ^b   Jendeberg, Lena ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BIOVITRUM AB   (Sweden)

^c NONE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ASSAYS; BENZENE; GENES; GLUCOSE; INSULIN; SENSITIVITY ANALYSIS;

BINDING EPITOPE; BIOLOGICAL ACTIVITY; GENE ASSAYS;

BIOCHEMISTRY;

AMINOBENZOIC ACID DERIVATIVE; BVT 13; BVT 762; BVT 763; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIABETES MELLITUS; DISEASE MODEL; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; GLUCOSE HOMEOSTASIS; INSULIN SENSITIVITY; LIPID METABOLISM; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REPORTER GENE; TRIACYLGLYCEROL BLOOD LEVEL; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZOIC ACIDS; BENZOPHENONES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; GENES, REPORTER; GLUCOSE; HYPOGLYCEMIC AGENTS; LIGANDS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; THIAZOLIDINEDIONES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRIGLYCERIDES;

ANIMALIA;

EID: 4644313413     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401552200     Document Type: Article

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