Andrographolide induces cell cycle arrest at G2/M phase and cell death in HepG2 cells via alteration of reactive oxygen species

European Journal of Pharmacology

Volumn 568, Issue 1-3, 2007, Pages 31-44

  Li, Jieliang ^a   Cheung, Hon Yeung ^a   Zhang, Zhiqiang ^a   Chan, Gallant K L ^a   Fong, Wang Fun ^a  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Andrographolide; Cell cycle arrest; Cell death; HepG2 cell; Mitochondrial membrane potential; Reactive oxygen species

Indexed keywords

ANDROGRAPHOLIDE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE INHIBITOR; DNA FRAGMENT; GLUTATHIONE; HYDROGEN PEROXIDE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CDC2 PROTEIN KINASE; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DNA FRAGMENTATION; G2 PHASE; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34250825923     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.04.027     Document Type: Article

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