Signalling apoptosis: A radical approach

Redox Report

Volumn 6, Issue 2, 2001, Pages 77-90

  Carmody, R J ^a   Cotter, T G ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; APOPTOSIS SIGNALLING KINASE 1; CYTOCHROME C; FAS ANTIGEN; GLUTATHIONE; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; HLA DR5 ANTIGEN; HLA DR6 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN BCL 2; PROTEIN P53; PROTEIN P55; REACTIVE OXYGEN METABOLITE; THIOREDOXIN; TOXIN; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; CATALYSIS; CELL DEATH; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; ENZYME MECHANISM; LIPID OXIDATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PATHOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

ANIMALS; ANTIGENS, CD95; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASES; CYTOCHROME C GROUP; ENZYME ACTIVATION; FAS LIGAND PROTEIN; GLUTATHIONE; ION CHANNELS; LIPID PEROXIDATION; MAMMALS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTORS, TUMOR NECROSIS FACTOR; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIGNAL TRANSDUCTION; THIOREDOXIN; TUMOR SUPPRESSOR PROTEIN P53; YEASTS;

EID: 0034991034     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100001101536085     Document Type: Review

References (174)

1. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
2. Caspases: Enemies within
3. Deciphering the pathways of life and death
4. The mitochondrial death/life regulator in apoptosis and necrosis
5. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
6. Nitric oxide-mediated apoptosis in murine peritoneal macrophages
7. Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines
8. Oxidized LDLs induce massive apoptosis of cultured human endothelial cells through a calcium-dependent pathway. Prevention by aurintricarboxylic acid
9. Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: Oxidative stress as a mediator of apoptosis
10. Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis
11. The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult
12. Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis
13. Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
14. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
15. The role of intracellular oxidants in apoptosis
16. Induction of apoptosis at different oxygen tensions: Evidence that oxygen radicals do not mediate apoptotic signaling
17. Programmed cell death and Bcl-2 protection in very low oxygen
18. Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes
19. Signalling mechanisms and oxidative stress in apoptosis
20. Inhibition of glutathione efflux from isolated rat hepatocytes by methionine
21. Non-oxidative loss of glutathione in apoptosis via GSH extrusion
22. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody
23. A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes
24. Rescue of cells from apoptosis by inhibition of active GSH extrusion
25. Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers
26. Apoptosis or necrosis: Intracellular levels of glutathione influence mode of cell death
27. Programmed cell death and AIDS pathogenesis: Significance and potential mechanisms
28. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
29. Oxidative stress and the pathogenesis of Parkinson's disease
30. + toxicity in nigral dopaminergic neurones
31. The point of no return: Mitochondria, caspases, and the commitment to cell death
32. Origin of eukaryotic programmed cell death: A consequence of aerobic metabolism?
33. The evolution of a mechanism of cell suicide
34. Mitochondria and apoptosis
35. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
36. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
37. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
38. Mitochondrial calcium transport
39. The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides
40. The mitochondrial permeability transition pore and its role in cell death
41. Mitochondrial permeability transition is a central coordinating event of apoptosis
42. Mitochondrial permeability transition triggers lymphocyte apoptosis
43. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
44. Mitochondrial control of nuclear apoptosis
45. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
46. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
47. The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage
48. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
49. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
50. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
51. Investigation of bax-induced release of cytochrome c from yeast mitochondria - Permeability of mitochondrial membranes, role of VDAC and ATP requirement
52. Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis
53. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
54. Intracellular ATP, a switch in the decision between apoptosis and necrosis
55. Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors
56. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
57. Synthesis and release of ATP by soluble mitochondrial F1 in complex with its inhibitor protein during dimethylsulfoxide-water transitions
58. Oxidation of critical thiol residue of the adenine nucleotide translocator enforces Bcl 2-independent permeability transition pore opening and apoptosis
59. The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event
60. The antioxidant functions of cytochrome c
61. Cytochrome c in the apoptotic and antioxidant cascades
62. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
63. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance
64. GSH extrusion and the mitochondrial pathway of apoptotic signalling
65. Gene microarray identification of redox and mitochondrial elements that control resistance of sensitivity to apoptosis
66. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
67. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
68. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
69. Bcl-2 family proteins: The role of the BH3 domain in apoptosis
70. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
71. Checkpoints of dueling dimers foil death wishes
72. Apoptosis. A sticky business
73. Double identity for proteins of the Bcl-2 family
74. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
75. Bcl-x(L) forms an ion channel in synthetic lipid membranes
76. Channel formation by antiapoptotic protein Bcl-2
77. Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
78. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
79. Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death
80. Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice
81. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols
82. Bcl-2 expression causes redistribution of glutathione to the nucleus
83. Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal
84. BCL-2 and glutathione: Alterations in cellular redox state that regulate apoptosis sensitivity
85. The Bcl-2 oncoprotein functions as a pro-oxidant
86. Nicotinamide nucleotide transhydrogenase: A model for utilization of substrate binding energy for proton translocation
87. Physiological roles of nicotinamide nucleotide transhydrogenase
88. Apoptosis by death factor
89. Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lymphomas
90. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
91. The receptor for the cytotoxic ligand TRAIL
92. TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL
93. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
94. A yeast mutant showing diagnostic markers of early and late apoptosis
95. Two CD95 (APO-1/Fas) signaling pathways
96. No requirement of reactive oxygen intermediates in Fas-mediated apoptosis
97. 2 in breast carcinoma cells
98. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
99. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
100. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
101. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphringo-myelinase in the progpagation of the apoptotic signal
102. Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells
103. Thiol-mediated inhibition of FAS and CD2 apoptotic signaling in activated human peripheral T cells
104. Eosinophil apoptosis is mediated by stimulators of cellular oxidative metabolism and inhibited by antioxidants: Involvement of a thiol-sensitive redox regulation in eosinophil cell death
105. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: The role of reactive oxygen species
106. Dual mechanism of Fas-induced cell death in neuroglioma cells: A role for reactive oxygen species
107. Protective activity of adult T cell leukemia-derived factor (ADF) against tumor necrosis factor-dependent cytotoxicity on U937 cells
108. Fas-induced apoptosis is mediated by activation of a Ras and Rac protein-regulated signaling pathway
109. Fas or ceramide induce apoptosis by Ras-regulated phosphoinositide-3-kinase activation
110. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153
111. 2-synthesis
112. FAS-induced apoptosis is mediated via ceramide-initiated RAS signaling pathway
113. Involvement of reactive oxygen species produced via NADPH oxidase in tyrosine phosphorylation in human B- and T-lineage lymphoid cells
114. Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis
115. Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
116. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction
117. Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: Relevance to ceramide-induced apoptosis
118. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
119. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
120. Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
121. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
122. Mechanisms of CD95 (APO-1 Fas)-mediated apoptosis
123. 2+ - and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain
124. Susceptibility of protein kinase C to oxidative inactivation: Loss of both phosphotransferase activity and phorbol diester binding
125. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing
126. Downregulation of Fas ligand by shedding
127. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)
128. Reactive oxygen species and programmed cell death
129. 2 for platelet-derived growth factor signal transduction
130. Hematopoietic growth factors signal through the formation of reactive oxygen species
131. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation
132. Redox regulation of cellular signalling
133. Oxidative stress and gene regulation
134. Redox regulation of transcriptional activators
135. Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways
136. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor
137. Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein-tyrosine phosphatase 1B
138. Regulation of PTP1B via glutathionylation of the active site cysteine 215
139. Redox regulation by thioredoxin and thioredoxin reductase
140. Thioredoxin redox control of cell growth and death and the effects of inhibitors
141. Mechanisms of the regulation of thioredoxin in reductase activity in cancer cells by the chemopreventive agent selenium
142. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
143. Studies on the mechanism of formation of 4-hydroxynonenal during microsomal lipid peroxidation
144. Evidence that 4-hydroxynonental mediates oxidative stress-induced neuronal apoptosis
145. 4-Hydroxynonenal induces oxidative stress and death of cultured spinal cord neurons
146. 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death
147. Lipid oxidation products in cell signaling
148. HNE interacts directly with JNK isoforms in human hepatic stellate cells
149. p53 and apoptosis
150. A model for p53-induced apoptosis
151. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2
152. Reactive oxygen species are downstream mediators of p53-dependent apoptosis
153. The origin of programmed cell death
154. Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae
155. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax
156. Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system [published erratum appears in Proc Natl Acad Sci USA 1995; 92: 2016]
157. Reconstitution of caspase-mediated cell-death signalling in Schizosaccharomyces pombe
158. Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae
159. CED-4 induces chromatin condensation in Schizosacharomyces pombe and is inhibited by direct physical association with CED-9
160. Human p53 inhibits growth in Schizosaccharomyces pombe
161. Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae
162. Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe
163. Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms
164. Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2
165. Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells
166. Modulation of cell death in yeast by the Bcl-2 family of proteins
167. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species
168. Oxygen stress: A regulator of apoptosis in yeast
169. Apoptosis without caspases: An inefficient molecular guillotine?
170. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
171. Oxidative stress induces caspase-independent retinal apoptosis in vitro
172. Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells
173. + thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway
174. Bcl-2 prevents caspase-independent cell death