메뉴 건너뛰기




Volumn 16, Issue 3, 2007, Pages 146-153

Progress in basic inflammatory bowel disease research

Author keywords

Crohn's disease; Environment; Genetic susceptibility; Gut flora; Inflammatory bowel disease; Ulcerative colitis

Indexed keywords

ARTICLE; BASIC RESEARCH; ENTERITIS; ENVIRONMENTAL FACTOR; GENOMICS; HEREDITY; HUMAN; IMMUNOREACTIVITY; INTESTINE FLORA; MEDICAL RESEARCH; NONHUMAN; PATHOGENESIS; PHARMACOGENOMICS; PRIORITY JOURNAL; PROTEOMICS; TISSUE INJURY;

EID: 34250804761     PISSN: 10558586     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.sempedsurg.2007.04.002     Document Type: Article
Times cited : (39)

References (85)
  • 1
    • 23344431535 scopus 로고    scopus 로고
    • Defects of mucosal immunity leading to Crohn's disease
    • Cobrin G.M., and Abreu M.T. Defects of mucosal immunity leading to Crohn's disease. Immunol Rev 206 (2005) 277-295
    • (2005) Immunol Rev , vol.206 , pp. 277-295
    • Cobrin, G.M.1    Abreu, M.T.2
  • 2
    • 23344446340 scopus 로고    scopus 로고
    • Defects of mucosal immunity leading to ulcerative colitis
    • Targan S.R., and Karp L.C. Defects of mucosal immunity leading to ulcerative colitis. Immunol Rev 206 (2005) 296-305
    • (2005) Immunol Rev , vol.206 , pp. 296-305
    • Targan, S.R.1    Karp, L.C.2
  • 3
    • 33748449654 scopus 로고    scopus 로고
    • Challenges in pediatric inflammatory bowel disease
    • Bousvaros A., Sylvester F., Kugathasan S., et al. Challenges in pediatric inflammatory bowel disease. Inflamm Bowel Dis 12 (2006) 886-913
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 886-913
    • Bousvaros, A.1    Sylvester, F.2    Kugathasan, S.3
  • 4
    • 0034680096 scopus 로고    scopus 로고
    • Changing patterns of infectious disease
    • Cohen M.L. Changing patterns of infectious disease. Nature 406 (2000) 762-767
    • (2000) Nature , vol.406 , pp. 762-767
    • Cohen, M.L.1
  • 5
    • 21844439780 scopus 로고    scopus 로고
    • The emergence of inflammatory bowel disease in the Asian Pacific region
    • Ouyang Q., Tandon R., Goh K.-L., et al. The emergence of inflammatory bowel disease in the Asian Pacific region. Curr Opin Gastroenterol 21 (2005) 408-413
    • (2005) Curr Opin Gastroenterol , vol.21 , pp. 408-413
    • Ouyang, Q.1    Tandon, R.2    Goh, K.-L.3
  • 6
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach J.-F. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347 (2002) 911-920
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.-F.1
  • 7
    • 3342988481 scopus 로고    scopus 로고
    • Inflammatory bowel disease: the role of environmental factors
    • Danese S., Sans M., and Fiocchi C. Inflammatory bowel disease: the role of environmental factors. Autoimmunity Rev 3 (2004) 390-400
    • (2004) Autoimmunity Rev , vol.3 , pp. 390-400
    • Danese, S.1    Sans, M.2    Fiocchi, C.3
  • 8
    • 0032008444 scopus 로고    scopus 로고
    • Inflammatory bowel disease and smoking: a review
    • Thomas G.A.O., Rhodes J., and Green J.T. Inflammatory bowel disease and smoking: a review. Am J Gastroenterol 93 (1998) 144-149
    • (1998) Am J Gastroenterol , vol.93 , pp. 144-149
    • Thomas, G.A.O.1    Rhodes, J.2    Green, J.T.3
  • 9
    • 0031777843 scopus 로고    scopus 로고
    • Oral contraceptive use and smoking are risk factors for relapse of Crohn's disease
    • Timmer A., Sutherland L.R., and Martin F. Oral contraceptive use and smoking are risk factors for relapse of Crohn's disease. Gastroenterology 114 (1998) 1143-1150
    • (1998) Gastroenterology , vol.114 , pp. 1143-1150
    • Timmer, A.1    Sutherland, L.R.2    Martin, F.3
  • 10
    • 0028216254 scopus 로고
    • Appendectomy protects against ulcerative colitis
    • Rutgeerts P., D'Haens G., Hiele M., et al. Appendectomy protects against ulcerative colitis. Gastroenterology 106 (1994) 1251-1253
    • (1994) Gastroenterology , vol.106 , pp. 1251-1253
    • Rutgeerts, P.1    D'Haens, G.2    Hiele, M.3
  • 11
    • 0037221708 scopus 로고    scopus 로고
    • Appendectomy is followed by increased risk of Crohn's disease
    • Andersson R.E., Olaison G., Tysk C., et al. Appendectomy is followed by increased risk of Crohn's disease. Gastroenterology 124 (2003) 40-46
    • (2003) Gastroenterology , vol.124 , pp. 40-46
    • Andersson, R.E.1    Olaison, G.2    Tysk, C.3
  • 12
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J.-P., Chamaiilard M., Zouali H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 (2001) 599-603
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.-P.1    Chamaiilard, M.2    Zouali, H.3
  • 13
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in Nod2 associated with susceptibility to Crohn's disease
    • Ogura Y., Bonen D.K., Inohara N., et al. A frameshift mutation in Nod2 associated with susceptibility to Crohn's disease. Nature 411 (2001) 603-606
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 14
    • 32044475178 scopus 로고    scopus 로고
    • Advances and perspectives in the genetics of inflammatory bowel disease
    • Chamaillard M., Iacob R., Desreumaux P., et al. Advances and perspectives in the genetics of inflammatory bowel disease. Clin Gastroenterol Hepatol 4 (2006) 143-151
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 143-151
    • Chamaillard, M.1    Iacob, R.2    Desreumaux, P.3
  • 15
    • 0038389762 scopus 로고    scopus 로고
    • IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and indentification of a novel association with ulcerative colitis
    • Giallourakis C., Stoll M., Miller K., et al. IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and indentification of a novel association with ulcerative colitis. Am J Hum Genet 73 (2003) 205-211
    • (2003) Am J Hum Genet , vol.73 , pp. 205-211
    • Giallourakis, C.1    Stoll, M.2    Miller, K.3
  • 16
    • 0142138025 scopus 로고    scopus 로고
    • Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease
    • Negoro K., McGovern D.P., Kinouchi Y., et al. Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease. Gut 52 (2003) 541-546
    • (2003) Gut , vol.52 , pp. 541-546
    • Negoro, K.1    McGovern, D.P.2    Kinouchi, Y.3
  • 17
    • 33744808327 scopus 로고    scopus 로고
    • Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease
    • Babusukumar U., Wang T., McGuire E., et al. Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease. Am J Gastroenterol 101 (2006) 1-8
    • (2006) Am J Gastroenterol , vol.101 , pp. 1-8
    • Babusukumar, U.1    Wang, T.2    McGuire, E.3
  • 18
    • 2442519456 scopus 로고    scopus 로고
    • Genetic variation in DLG5 is associated with inflammatory bowel disease
    • Stoll M., Corneliussen B., Costello C.M., et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 36 (2004) 476-480
    • (2004) Nat Genet , vol.36 , pp. 476-480
    • Stoll, M.1    Corneliussen, B.2    Costello, C.M.3
  • 19
    • 33645012263 scopus 로고    scopus 로고
    • Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men
    • Friedrichs F., Brescianini S., Annese V., et al. Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men. Hum Genet 119 (2006) 305-311
    • (2006) Hum Genet , vol.119 , pp. 305-311
    • Friedrichs, F.1    Brescianini, S.2    Annese, V.3
  • 20
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: mice deficient for the multiple drug resitance gene, mdr1a, spontaneously develop colitis
    • Panwala C.M., Jones J.C., and Viney J.L. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resitance gene, mdr1a, spontaneously develop colitis. J Immunol 161 (1998) 5733-5744
    • (1998) J Immunol , vol.161 , pp. 5733-5744
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 21
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R.H., Taylor K.D., Brant S.R., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314 (2006) 1461-1463
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 22
    • 0141835046 scopus 로고    scopus 로고
    • Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    • Becker C., Wirtz S., Blessing M., et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 112 (2003) 693-706
    • (2003) J Clin Invest , vol.112 , pp. 693-706
    • Becker, C.1    Wirtz, S.2    Blessing, M.3
  • 23
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B., Lesley R., Blom B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000) 715-725
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 24
    • 0036725827 scopus 로고    scopus 로고
    • Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    • Abreu M.T., Taylor K.D., Ling Y.C., et al. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology 123 (2002) 679-688
    • (2002) Gastroenterology , vol.123 , pp. 679-688
    • Abreu, M.T.1    Taylor, K.D.2    Ling, Y.C.3
  • 25
    • 9144271221 scopus 로고    scopus 로고
    • CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease
    • Kugathasan S., Collins N., Maresso K., et al. CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn's disease. Clin Gastroenterol Hepatol 2 (2004) 1003-1009
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 1003-1009
    • Kugathasan, S.1    Collins, N.2    Maresso, K.3
  • 26
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi K.S., Chamaillard M., Ogura Y., et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 (2005) 731-734
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 27
    • 0021709791 scopus 로고
    • Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn's disease
    • Chiodini R.J., Kruiningen H.J.V., Thayer W.R., et al. Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn's disease. Dig Dis Sci 29 (1984) 1073-1079
    • (1984) Dig Dis Sci , vol.29 , pp. 1073-1079
    • Chiodini, R.J.1    Kruiningen, H.J.V.2    Thayer, W.R.3
  • 28
    • 0031902581 scopus 로고    scopus 로고
    • Controlled trial of antituberculous chemotherapy in Crohn's disease: a five year follow up study
    • Thomas G.A.O., Swift G.L., Green J.T., et al. Controlled trial of antituberculous chemotherapy in Crohn's disease: a five year follow up study. Gut 42 (1998) 497-500
    • (1998) Gut , vol.42 , pp. 497-500
    • Thomas, G.A.O.1    Swift, G.L.2    Green, J.T.3
  • 29
    • 0031758230 scopus 로고    scopus 로고
    • Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
    • Darfeuille-Michaud A., Neut C., Barnich N., et al. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology 115 (1998) 1405-1413
    • (1998) Gastroenterology , vol.115 , pp. 1405-1413
    • Darfeuille-Michaud, A.1    Neut, C.2    Barnich, N.3
  • 30
    • 0027223084 scopus 로고
    • Evidence of persistent measles virus infection in Crohn's disease
    • Wakefield A.J., Pittilo R.M., Sim R., et al. Evidence of persistent measles virus infection in Crohn's disease. J Med Virol 39 (1993) 345-353
    • (1993) J Med Virol , vol.39 , pp. 345-353
    • Wakefield, A.J.1    Pittilo, R.M.2    Sim, R.3
  • 31
    • 0030600341 scopus 로고    scopus 로고
    • Crohn's disease after in-utero measles virus exposure
    • Ekbom A., Daszak P., Kraaz W., et al. Crohn's disease after in-utero measles virus exposure. Lancet 348 (1996) 515-517
    • (1996) Lancet , vol.348 , pp. 515-517
    • Ekbom, A.1    Daszak, P.2    Kraaz, W.3
  • 32
    • 15544382565 scopus 로고    scopus 로고
    • Immunity, inflammation, and allergy in the gut
    • MacDonald T.T., and Monteleone G. Immunity, inflammation, and allergy in the gut. Science 307 (2005) 1920-1925
    • (2005) Science , vol.307 , pp. 1920-1925
    • MacDonald, T.T.1    Monteleone, G.2
  • 33
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • Strober W., Fuss I.J., and Blumberg R.S. The immunology of mucosal models of inflammation. Annu Rev Immunol 20 (2002) 495-549
    • (2002) Annu Rev Immunol , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3
  • 35
    • 0031915148 scopus 로고    scopus 로고
    • Early lesions caused by infusion of intestinal contents in excluded ileum of Crohn's disease
    • D'Haens G., Geboes K., Peeters M., et al. Early lesions caused by infusion of intestinal contents in excluded ileum of Crohn's disease. Gastroenterology 114 (1998) 262-267
    • (1998) Gastroenterology , vol.114 , pp. 262-267
    • D'Haens, G.1    Geboes, K.2    Peeters, M.3
  • 36
    • 0032907877 scopus 로고    scopus 로고
    • Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative?
    • Campieri M., and Gionchetti P. Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative?. Gastroenterology 116 (1999) 1246-1260
    • (1999) Gastroenterology , vol.116 , pp. 1246-1260
    • Campieri, M.1    Gionchetti, P.2
  • 37
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    • Targan S.R., Landers C.J., Yang H., et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 128 (2005) 2020-2028
    • (2005) Gastroenterology , vol.128 , pp. 2020-2028
    • Targan, S.R.1    Landers, C.J.2    Yang, H.3
  • 38
    • 0029586031 scopus 로고
    • Tolerance exists towards resident intestinal flora but it is broken in active inflammatory bowel disease (IBD)
    • Duchmann R., Kaiser I., Hermann E., et al. Tolerance exists towards resident intestinal flora but it is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 102 (1995) 448-455
    • (1995) Clin Exp Immunol , vol.102 , pp. 448-455
    • Duchmann, R.1    Kaiser, I.2    Hermann, E.3
  • 39
    • 19544366408 scopus 로고    scopus 로고
    • Commensal gut bacteria: mechanisms of immune modulation
    • Kelly D., Conway S., and Aminov R. Commensal gut bacteria: mechanisms of immune modulation. Trends Immunol 26 (2005) 326-333
    • (2005) Trends Immunol , vol.26 , pp. 326-333
    • Kelly, D.1    Conway, S.2    Aminov, R.3
  • 40
    • 0345303939 scopus 로고    scopus 로고
    • Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing
    • Girardin S.E., Hugot J.-P., and Sansonetti P.J. Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol 24 (2003) 652-658
    • (2003) Trends Immunol , vol.24 , pp. 652-658
    • Girardin, S.E.1    Hugot, J.-P.2    Sansonetti, P.J.3
  • 41
    • 84891447998 scopus 로고    scopus 로고
    • The normal intestinal mucosa: a state of "controlled inflammation."
    • Targan S.R., and Shanahan F. (Eds), Kluwer Academic Publishers, Dordrecht
    • Fiocchi C. The normal intestinal mucosa: a state of "controlled inflammation.". In: Targan S.R., and Shanahan F. (Eds). Inflammatory Bowel Disease. From Bench to Bedside. (2nd ed.) (2003), Kluwer Academic Publishers, Dordrecht 101-120
    • (2003) Inflammatory Bowel Disease. From Bench to Bedside. (2nd ed.) , pp. 101-120
    • Fiocchi, C.1
  • 42
    • 0037380969 scopus 로고    scopus 로고
    • CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells
    • Hisamatsu T., Suzuki M., Reinecker H.-C., et al. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 124 (2003) 993-1000
    • (2003) Gastroenterology , vol.124 , pp. 993-1000
    • Hisamatsu, T.1    Suzuki, M.2    Reinecker, H.-C.3
  • 43
    • 0141534407 scopus 로고    scopus 로고
    • The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria
    • Staag A.J., Hart A.L., Knight S.C., et al. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut 52 (2003) 1522-1529
    • (2003) Gut , vol.52 , pp. 1522-1529
    • Staag, A.J.1    Hart, A.L.2    Knight, S.C.3
  • 44
    • 22344448660 scopus 로고    scopus 로고
    • Characteristics of intestinal dendritic cells in inflammatory bowel disease
    • Hart A.L., Al-Hassi H.O., Rigby R.J., et al. Characteristics of intestinal dendritic cells in inflammatory bowel disease. Gastroenterology 129 (2005) 50-65
    • (2005) Gastroenterology , vol.129 , pp. 50-65
    • Hart, A.L.1    Al-Hassi, H.O.2    Rigby, R.J.3
  • 45
    • 7244257312 scopus 로고    scopus 로고
    • NOD2(CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression
    • Wehkamp J., Harder J., Weichenthal M., et al. NOD2(CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression. Gut 53 (2004) 1658-1664
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 46
    • 0142026070 scopus 로고    scopus 로고
    • Inducible and constitutive β-defensins are differentially expressed in Crohn's disease and ulcerative colitis
    • Wehkamp J., Harder J., Weichenthal M., et al. Inducible and constitutive β-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 9 (2003) 215-223
    • (2003) Inflamm Bowel Dis , vol.9 , pp. 215-223
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 47
    • 5444254408 scopus 로고    scopus 로고
    • Toll-like receptors in the pathogenesis of human disease
    • Cook D.N., Pisetsky D.S., and Schwartz D.A. Toll-like receptors in the pathogenesis of human disease. Nat Immunol 5 (2004) 975-979
    • (2004) Nat Immunol , vol.5 , pp. 975-979
    • Cook, D.N.1    Pisetsky, D.S.2    Schwartz, D.A.3
  • 48
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118 (2004) 229-241
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3
  • 49
    • 0034445697 scopus 로고    scopus 로고
    • Differential alterationin intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario E., and Podolsky D.K. Differential alterationin intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68 (2000) 7010-7017
    • (2000) Infect Immun , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 50
    • 3042521641 scopus 로고    scopus 로고
    • Deficient host-bacteria interactions in inflammatory bowel disease?. The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis
    • Franchimont D., Vermeire S., ElHousni H., et al. Deficient host-bacteria interactions in inflammatory bowel disease?. The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 53 (2004) 987-992
    • (2004) Gut , vol.53 , pp. 987-992
    • Franchimont, D.1    Vermeire, S.2    ElHousni, H.3
  • 51
    • 3242732415 scopus 로고    scopus 로고
    • Crohn's disease is associated with a toll-like receptor-9 polymorphism
    • Torok H.-P., Glas J., Tonenchi L., et al. Crohn's disease is associated with a toll-like receptor-9 polymorphism. Gastroenterology 127 (2004) 365-366
    • (2004) Gastroenterology , vol.127 , pp. 365-366
    • Torok, H.-P.1    Glas, J.2    Tonenchi, L.3
  • 52
    • 4444332518 scopus 로고    scopus 로고
    • Regulation of IL-8 and IL-1β expression in Crohn's disease associated with NOD2/CARD15 mutations
    • Li J., Moran T., Swanson E., et al. Regulation of IL-8 and IL-1β expression in Crohn's disease associated with NOD2/CARD15 mutations. Hum Mol Genet 13 (2004) 1715-1725
    • (2004) Hum Mol Genet , vol.13 , pp. 1715-1725
    • Li, J.1    Moran, T.2    Swanson, E.3
  • 53
    • 21144468350 scopus 로고    scopus 로고
    • Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
    • van Heel D.A., Gosh S., Butler M., et al. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 365 (2005) 1794-1796
    • (2005) Lancet , vol.365 , pp. 1794-1796
    • van Heel, D.A.1    Gosh, S.2    Butler, M.3
  • 54
    • 0021966921 scopus 로고
    • Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immunoglobulin G from idiopathic ulcerative colitis
    • Takahashi F., and Das K.M. Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immunoglobulin G from idiopathic ulcerative colitis. J Clin Invest 76 (1985) 311-318
    • (1985) J Clin Invest , vol.76 , pp. 311-318
    • Takahashi, F.1    Das, K.M.2
  • 55
    • 0002012185 scopus 로고    scopus 로고
    • Cytokines, chemokines, growth factors, eicosanoids and other bioactive molecules in IBD
    • Kirsner J.B. (Ed), W.B. Saunders, Philadelphia, PA
    • Podolsky D.K., and Fiocchi C. Cytokines, chemokines, growth factors, eicosanoids and other bioactive molecules in IBD. In: Kirsner J.B. (Ed). Inflammatory Bowel Disease (1999), W.B. Saunders, Philadelphia, PA 191-207
    • (1999) Inflammatory Bowel Disease , pp. 191-207
    • Podolsky, D.K.1    Fiocchi, C.2
  • 56
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    • Neurath M.F., Weigmann B., Finotto S., et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med 195 (2002) 1129-1143
    • (2002) J Exp Med , vol.195 , pp. 1129-1143
    • Neurath, M.F.1    Weigmann, B.2    Finotto, S.3
  • 57
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone G., Biancone L., Marasco R., et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112 (1997) 1169-1178
    • (1997) Gastroenterology , vol.112 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3
  • 58
    • 0033152023 scopus 로고    scopus 로고
    • IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells
    • Pizarro T.P., Michie M.H., Bentz M., et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 162 (1999) 6829-6835
    • (1999) J Immunol , vol.162 , pp. 6829-6835
    • Pizarro, T.P.1    Michie, M.H.2    Bentz, M.3
  • 59
    • 0033565302 scopus 로고    scopus 로고
    • Resistance of Crohn's disease T-cells to multiple apoptotic stimuli is associated with a Bcl-2/Bax mucosal imbalance
    • Ina K., Itoh J., Fukushima K., et al. Resistance of Crohn's disease T-cells to multiple apoptotic stimuli is associated with a Bcl-2/Bax mucosal imbalance. J Immunol 163 (1999) 1081-1090
    • (1999) J Immunol , vol.163 , pp. 1081-1090
    • Ina, K.1    Itoh, J.2    Fukushima, K.3
  • 60
    • 7244251444 scopus 로고    scopus 로고
    • Divergent cell cycle kinetic sunderlie the distinct functional capacity of mucosal T-cells in Crohn's disease (CD) and ulcerative colitis (UC)
    • Sturm A., Leite A.Z., Danese S., et al. Divergent cell cycle kinetic sunderlie the distinct functional capacity of mucosal T-cells in Crohn's disease (CD) and ulcerative colitis (UC). Gut 53 (2004) 1624-1631
    • (2004) Gut , vol.53 , pp. 1624-1631
    • Sturm, A.1    Leite, A.Z.2    Danese, S.3
  • 61
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss I.J., Neurath M., Boirivant M., et al. Disparate CD4+ lamina propria lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157 (1996) 1261-1270
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 62
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • Fuss I.J., Heller F., Boirivant M., et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 113 (2004) 1490-1497
    • (2004) J Clin Invest , vol.113 , pp. 1490-1497
    • Fuss, I.J.1    Heller, F.2    Boirivant, M.3
  • 63
    • 33744984785 scopus 로고    scopus 로고
    • Th17: an effector CD4 T cell lineage with regulatory T cell ties
    • Weaver C.T., Harrington L.E., Mangan P.R., et al. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24 (2006) 677-688
    • (2006) Immunity , vol.24 , pp. 677-688
    • Weaver, C.T.1    Harrington, L.E.2    Mangan, P.R.3
  • 64
    • 33646417072 scopus 로고    scopus 로고
    • The IL-23/IL-17 axis in inflammation
    • Iwakura Y., and Ishigame H. The IL-23/IL-17 axis in inflammation. J Clin Invest 116 (2006) 1218-1222
    • (2006) J Clin Invest , vol.116 , pp. 1218-1222
    • Iwakura, Y.1    Ishigame, H.2
  • 65
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D., Cheung J., Scheerens H., et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116 (2006) 1310-1316
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 66
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S., Andoh A., Bamba S., et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52 (2003) 65-70
    • (2003) Gut , vol.52 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 68
    • 4344682025 scopus 로고    scopus 로고
    • bright T cells in human intestinal lamina propria as regulatory cells
    • bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 173 (2004) 3119-3130
    • (2004) J Immunol , vol.173 , pp. 3119-3130
    • Makita, S.1    Kanai, T.2    Oshima, S.3
  • 69
    • 0020551753 scopus 로고
    • Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease
    • Selby W.S., Janossy G., Mason D.Y., et al. Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol 53 (1983) 614-618
    • (1983) Clin Exp Immunol , vol.53 , pp. 614-618
    • Selby, W.S.1    Janossy, G.2    Mason, D.Y.3
  • 70
    • 0025165778 scopus 로고
    • Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease
    • Mayer L., and Eisenhardt D. Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease. J Clin Invest 86 (1990) 1255-1260
    • (1990) J Clin Invest , vol.86 , pp. 1255-1260
    • Mayer, L.1    Eisenhardt, D.2
  • 71
    • 2142711024 scopus 로고    scopus 로고
    • The expression and function of costimulatory molecules B7h and B7-H1 on colonic epithelial cells
    • Nakazawa A., Dotan I., Brimnes J., et al. The expression and function of costimulatory molecules B7h and B7-H1 on colonic epithelial cells. Gastroenterology 126 (2004) 1347-1357
    • (2004) Gastroenterology , vol.126 , pp. 1347-1357
    • Nakazawa, A.1    Dotan, I.2    Brimnes, J.3
  • 72
    • 0032880168 scopus 로고    scopus 로고
    • Matrix metalloproteinases levels are elevated in inflammatory bowel disease
    • Baugh M.D., Perry M.J., Hollander A.P., et al. Matrix metalloproteinases levels are elevated in inflammatory bowel disease. Gastroenterology 117 (1999) 814-822
    • (1999) Gastroenterology , vol.117 , pp. 814-822
    • Baugh, M.D.1    Perry, M.J.2    Hollander, A.P.3
  • 73
    • 0032718351 scopus 로고    scopus 로고
    • Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury
    • Monteleone G., MacDonald T.T., Wathen N.C., et al. Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury. Gastroenterology 117 (1999) 1069-1077
    • (1999) Gastroenterology , vol.117 , pp. 1069-1077
    • Monteleone, G.1    MacDonald, T.T.2    Wathen, N.C.3
  • 74
    • 0346100583 scopus 로고    scopus 로고
    • CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines causing T-cell transmigration
    • Vogel J.D., West G.A., Sturm A., et al. CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines causing T-cell transmigration. Gastroenterology 126 (2004) 63-80
    • (2004) Gastroenterology , vol.126 , pp. 63-80
    • Vogel, J.D.1    West, G.A.2    Sturm, A.3
  • 75
    • 0032576359 scopus 로고    scopus 로고
    • Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease
    • Binion D.G., West G.A., Volk E.E., et al. Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease. Lancet 352 (1998) 1742-1746
    • (1998) Lancet , vol.352 , pp. 1742-1746
    • Binion, D.G.1    West, G.A.2    Volk, E.E.3
  • 76
    • 0034333259 scopus 로고    scopus 로고
    • Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion
    • Binion D.G., Rafiee P., Ramunujam K.S., et al. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radical Biol Med 29 (2000) 881-888
    • (2000) Free Radical Biol Med , vol.29 , pp. 881-888
    • Binion, D.G.1    Rafiee, P.2    Ramunujam, K.S.3
  • 77
    • 5444230139 scopus 로고    scopus 로고
    • Platelets: signaling cells in the immune continuum
    • Weyrich A.S., and Zimmerman G.A. Platelets: signaling cells in the immune continuum. Trends Immunol 25 (2004) 489-495
    • (2004) Trends Immunol , vol.25 , pp. 489-495
    • Weyrich, A.S.1    Zimmerman, G.A.2
  • 78
    • 0141534421 scopus 로고    scopus 로고
    • Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients
    • Danese S., Katz J.A., Saibeni S., et al. Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients. Gut 52 (2003) 1435-1441
    • (2003) Gut , vol.52 , pp. 1435-1441
    • Danese, S.1    Katz, J.A.2    Saibeni, S.3
  • 79
    • 0038297520 scopus 로고    scopus 로고
    • Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients
    • Danese S., delaMotte C., Sturm A., et al. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 124 (2003) 1249-1264
    • (2003) Gastroenterology , vol.124 , pp. 1249-1264
    • Danese, S.1    delaMotte, C.2    Sturm, A.3
  • 80
    • 33744510694 scopus 로고    scopus 로고
    • Angiogenesis as a novel component of inflammatory bowel disease pathogenesis
    • Danese S., Sans M., delaMotte C., et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 130 (2006) 2060-2073
    • (2006) Gastroenterology , vol.130 , pp. 2060-2073
    • Danese, S.1    Sans, M.2    delaMotte, C.3
  • 81
    • 15444376177 scopus 로고    scopus 로고
    • Past and current theories of etiology of IBD. Toothpaste, worms, and refrigerators
    • Korzenik J.R. Past and current theories of etiology of IBD. Toothpaste, worms, and refrigerators. J Clin Gastroenterol 39 suppl 2 (2005) S59-S65
    • (2005) J Clin Gastroenterol , vol.39 , Issue.SUPPL. 2
    • Korzenik, J.R.1
  • 82
    • 3042683170 scopus 로고    scopus 로고
    • Update in inflammatory bowel disease pathogenesis
    • Rogler G. Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 20 (2004) 311-317
    • (2004) Curr Opin Gastroenterol , vol.20 , pp. 311-317
    • Rogler, G.1
  • 83
    • 33750217972 scopus 로고    scopus 로고
    • Current therapy of inflammatory bowel disease in children
    • Rufo P.A., and Bousvarors A. Current therapy of inflammatory bowel disease in children. Pediatr Drugs 8 (2006) 279-302
    • (2006) Pediatr Drugs , vol.8 , pp. 279-302
    • Rufo, P.A.1    Bousvarors, A.2
  • 84
    • 0036093570 scopus 로고    scopus 로고
    • Biological therapy of inflammatory bowel disease
    • Sandborn W.J., and Targan S.R. Biological therapy of inflammatory bowel disease. Gastroenterology 122 (2002) 1592-1608
    • (2002) Gastroenterology , vol.122 , pp. 1592-1608
    • Sandborn, W.J.1    Targan, S.R.2
  • 85
    • 2442453484 scopus 로고    scopus 로고
    • Therapeutic manipulation of the enteric microflora in inflammatory bowel disease: antibiotics, probiotics, and prebiotics
    • Sartor R.B. Therapeutic manipulation of the enteric microflora in inflammatory bowel disease: antibiotics, probiotics, and prebiotics. Gastroenterology 126 (2004) 1620-1633
    • (2004) Gastroenterology , vol.126 , pp. 1620-1633
    • Sartor, R.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.