-
1
-
-
0027418818
-
Molecular cloning and characterization of PKCθ, a human novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
-
Baier G., Telford D., Giampa L., et al. Molecular cloning and characterization of PKCθ, a human novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J Biol Chem 268 (1993) 4997-5004
-
(1993)
J Biol Chem
, vol.268
, pp. 4997-5004
-
-
Baier, G.1
Telford, D.2
Giampa, L.3
-
2
-
-
0027153592
-
Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets
-
Chang J.D., Xu Y., Raychowdhury M.K., et al. Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets. J Biol Chem 268 (1993) 14208-14214
-
(1993)
J Biol Chem
, vol.268
, pp. 14208-14214
-
-
Chang, J.D.1
Xu, Y.2
Raychowdhury, M.K.3
-
3
-
-
0026665459
-
A new member of the protein kinase C family, nPKCθ, predominantly expressed in skeletal muscle
-
Osada S., Mizuno K., Saido T.C., et al. A new member of the protein kinase C family, nPKCθ, predominantly expressed in skeletal muscle. Mol Cell Biol 12 (1992) 3930-3938
-
(1992)
Mol Cell Biol
, vol.12
, pp. 3930-3938
-
-
Osada, S.1
Mizuno, K.2
Saido, T.C.3
-
4
-
-
0037902559
-
Protein kinase C-θ (PKCθ): it's all about location, location, location
-
Altman A., and Villalba M. Protein kinase C-θ (PKCθ): it's all about location, location, location. Immunol Rev 192 (2003) 53-63
-
(2003)
Immunol Rev
, vol.192
, pp. 53-63
-
-
Altman, A.1
Villalba, M.2
-
5
-
-
0036604936
-
Protein kinase C-θ: signaling from the center of the T-cell synapse
-
Arendt C.W., Albrecht B., Soos T.J., et al. Protein kinase C-θ: signaling from the center of the T-cell synapse. Curr Opin Immunol 14 (2002) 323-330
-
(2002)
Curr Opin Immunol
, vol.14
, pp. 323-330
-
-
Arendt, C.W.1
Albrecht, B.2
Soos, T.J.3
-
6
-
-
85047682875
-
Protein kinase C-θ in T cell activation
-
Isakov N., and Altman A. Protein kinase C-θ in T cell activation. Annu Rev Immunol 20 (2002) 761-794
-
(2002)
Annu Rev Immunol
, vol.20
, pp. 761-794
-
-
Isakov, N.1
Altman, A.2
-
7
-
-
0034602963
-
Regulation of protein kinase Cθ function during T cell activation by Lck-mediated tyrosine phosphorylation
-
Liu Y., Witte S., Liu Y.C., et al. Regulation of protein kinase Cθ function during T cell activation by Lck-mediated tyrosine phosphorylation. J Biol Chem 275 (2000) 3603-3609
-
(2000)
J Biol Chem
, vol.275
, pp. 3603-3609
-
-
Liu, Y.1
Witte, S.2
Liu, Y.C.3
-
8
-
-
4444245423
-
Protein kinase C and beyond
-
Spitaler M., and Cantrell D.A. Protein kinase C and beyond. Nat Immunol 5 (2004) 785-790
-
(2004)
Nat Immunol
, vol.5
, pp. 785-790
-
-
Spitaler, M.1
Cantrell, D.A.2
-
9
-
-
0031012266
-
Selective modulation of protein kinase C-θ during T-cell activation
-
Monks C.R.F., Kupfer H., Tamir I., et al. Selective modulation of protein kinase C-θ during T-cell activation. Nature 385 (1997) 83-86
-
(1997)
Nature
, vol.385
, pp. 83-86
-
-
Monks, C.R.F.1
Kupfer, H.2
Tamir, I.3
-
10
-
-
0033538574
-
The immunological synapse: a molecular machine controlling T cell activation
-
Grakoui A., Bromley S.K., Sumen C., et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285 (1999) 221-227
-
(1999)
Science
, vol.285
, pp. 221-227
-
-
Grakoui, A.1
Bromley, S.K.2
Sumen, C.3
-
11
-
-
0034644505
-
Signaling takes shape in the immune system
-
Dustin M.L., and Chan A.C. Signaling takes shape in the immune system. Cell 103 (2000) 283-294
-
(2000)
Cell
, vol.103
, pp. 283-294
-
-
Dustin, M.L.1
Chan, A.C.2
-
12
-
-
0034232037
-
The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
-
Dustin M.L., and Cooper J.A. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol 1 (2000) 23-29
-
(2000)
Nat Immunol
, vol.1
, pp. 23-29
-
-
Dustin, M.L.1
Cooper, J.A.2
-
13
-
-
0033534525
-
The actin cytoskeleton and lymphocyte activation
-
Penninger J.M., and Crabtree G.R. The actin cytoskeleton and lymphocyte activation. Cell 96 (1999) 9-12
-
(1999)
Cell
, vol.96
, pp. 9-12
-
-
Penninger, J.M.1
Crabtree, G.R.2
-
14
-
-
0032545218
-
A receptor/cytoskeletal movement triggered by costimulation during T cell activation
-
Wülfing C., and Davis M.M. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282 (1998) 2266-2269
-
(1998)
Science
, vol.282
, pp. 2266-2269
-
-
Wülfing, C.1
Davis, M.M.2
-
15
-
-
0035037684
-
Lipid microdomains and the role of PKCθ in T cell activation
-
Bi K., and Altman A. Lipid microdomains and the role of PKCθ in T cell activation. Semin Immunol 13 (2001) 139-146
-
(2001)
Semin Immunol
, vol.13
, pp. 139-146
-
-
Bi, K.1
Altman, A.2
-
16
-
-
0035039037
-
Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes
-
Miceli M.C., Moran M., Chung C.D., et al. Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes. Semin Immunol 13 (2001) 115-128
-
(2001)
Semin Immunol
, vol.13
, pp. 115-128
-
-
Miceli, M.C.1
Moran, M.2
Chung, C.D.3
-
17
-
-
0032986671
-
Membrane compartmentation and the response to antigen
-
Xavier R., and Seed B. Membrane compartmentation and the response to antigen. Curr Opin Immunol 11 (1999) 265-269
-
(1999)
Curr Opin Immunol
, vol.11
, pp. 265-269
-
-
Xavier, R.1
Seed, B.2
-
18
-
-
0032480279
-
Three-dimensional segregation of supramolecular clusters in T cells
-
Monks C.R., Freiberg B.A., Kupfer H., et al. Three-dimensional segregation of supramolecular clusters in T cells. Nature 395 (1998) 82-86
-
(1998)
Nature
, vol.395
, pp. 82-86
-
-
Monks, C.R.1
Freiberg, B.A.2
Kupfer, H.3
-
19
-
-
27844473354
-
A dynamic view of the immunological synapse
-
Dustin M.L. A dynamic view of the immunological synapse. Semin Immunol 17 (2005) 400-410
-
(2005)
Semin Immunol
, vol.17
, pp. 400-410
-
-
Dustin, M.L.1
-
20
-
-
0035374476
-
Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
-
Bi K., Tanaka Y., Coudronniere N., et al. Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation. Nat Immunol 2 (2001) 556-563
-
(2001)
Nat Immunol
, vol.2
, pp. 556-563
-
-
Bi, K.1
Tanaka, Y.2
Coudronniere, N.3
-
21
-
-
0037105477
-
Cutting edge: quantitative imaging of raft accumulation in the immunological synapse
-
Burack W.R., Lee K.H., Holdorf A.D., et al. Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol 15 169 (2002) 2837-2841
-
(2002)
J Immunol
, vol.15
, Issue.169
, pp. 2837-2841
-
-
Burack, W.R.1
Lee, K.H.2
Holdorf, A.D.3
-
22
-
-
0037047136
-
CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse
-
Huang J., Lo P.F., Zal T., et al. CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse. Proc Natl Acad Sci USA 99 (2002) 9369-9373
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9369-9373
-
-
Huang, J.1
Lo, P.F.2
Zal, T.3
-
23
-
-
0032931973
-
Costimulatory regulation of T cell function
-
Chambers C.A., and Allison J.P. Costimulatory regulation of T cell function. Curr Opin Cell Biol 11 (1999) 203-210
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 203-210
-
-
Chambers, C.A.1
Allison, J.P.2
-
24
-
-
0030833571
-
T cell clonal anergy
-
Schwartz R.H. T cell clonal anergy. Curr Opin Immunol 9 (1997) 351-357
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 351-357
-
-
Schwartz, R.H.1
-
25
-
-
18844473151
-
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
-
Sun Z., Arendt C.W., Ellmeier W., et al. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404 (2000) 402-407
-
(2000)
Nature
, vol.404
, pp. 402-407
-
-
Sun, Z.1
Arendt, C.W.2
Ellmeier, W.3
-
26
-
-
0031204429
-
Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells
-
McGuire K.L., and Iacobelli M. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J Immunol 159 (1997) 1319-1327
-
(1997)
J Immunol
, vol.159
, pp. 1319-1327
-
-
McGuire, K.L.1
Iacobelli, M.2
-
27
-
-
28944445460
-
Differential roles of PKC-θ in the regulation of intracellular calcium concentration in primary T cells
-
Manicassamy S., Sadim M., Ye R.D., et al. Differential roles of PKC-θ in the regulation of intracellular calcium concentration in primary T cells. J Mol Biol 355 (2006) 347-359
-
(2006)
J Mol Biol
, vol.355
, pp. 347-359
-
-
Manicassamy, S.1
Sadim, M.2
Ye, R.D.3
-
28
-
-
0038620475
-
2+ mobilization and NFAT cell activation in primary mouse T cells
-
2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med 197 (2003) 1525-1535
-
(2003)
J Exp Med
, vol.197
, pp. 1525-1535
-
-
Pfeifhofer, C.1
Kofler, K.2
Gruber, T.3
-
29
-
-
8444225946
-
The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling
-
Lin X., and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol 16 (2004) 429-435
-
(2004)
Semin Immunol
, vol.16
, pp. 429-435
-
-
Lin, X.1
Wang, D.2
-
30
-
-
2342611054
-
T-cell-receptor- and B-cell-receptor-mediated activation of NF-κB in lymphocytes
-
Weil R., and Israel A. T-cell-receptor- and B-cell-receptor-mediated activation of NF-κB in lymphocytes. Curr Opin Immunol 16 (2004) 374-381
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 374-381
-
-
Weil, R.1
Israel, A.2
-
31
-
-
8644283766
-
The molecular adapter Carma1 controls entry of IκB kinase into the central immune synapse
-
Hara H., Bakal C., Wada T., et al. The molecular adapter Carma1 controls entry of IκB kinase into the central immune synapse. J Exp Med 200 (2004) 1167-1177
-
(2004)
J Exp Med
, vol.200
, pp. 1167-1177
-
-
Hara, H.1
Bakal, C.2
Wada, T.3
-
32
-
-
0037827638
-
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
-
Jun J.E., Wilson L.E., Vinuesa C.G., et al. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18 (2003) 751-762
-
(2003)
Immunity
, vol.18
, pp. 751-762
-
-
Jun, J.E.1
Wilson, L.E.2
Vinuesa, C.G.3
-
33
-
-
0036707520
-
A requirement for CARMA1 in TCR-induced NF-κB activation
-
Wang D., You Y., Case S.M., et al. A requirement for CARMA1 in TCR-induced NF-κB activation. Nat Immunol 3 (2002) 830-835
-
(2002)
Nat Immunol
, vol.3
, pp. 830-835
-
-
Wang, D.1
You, Y.2
Case, S.M.3
-
34
-
-
28844500398
-
Phosphorylation of the CARMA1 linker controls NF-κB activation
-
Sommer K., Guo B., Pomerantz J.L., et al. Phosphorylation of the CARMA1 linker controls NF-κB activation. Immunity 23 (2005) 561-574
-
(2005)
Immunity
, vol.23
, pp. 561-574
-
-
Sommer, K.1
Guo, B.2
Pomerantz, J.L.3
-
35
-
-
28844499919
-
Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-κB activation
-
Matsumoto R., Wang D., Blonska M., et al. Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-κB activation. Immunity 23 (2005) 575-585
-
(2005)
Immunity
, vol.23
, pp. 575-585
-
-
Matsumoto, R.1
Wang, D.2
Blonska, M.3
-
36
-
-
2342629277
-
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
-
Sun L., Deng L., Ea C.K., et al. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14 (2004) 289-301
-
(2004)
Mol Cell
, vol.14
, pp. 289-301
-
-
Sun, L.1
Deng, L.2
Ea, C.K.3
-
37
-
-
0036234459
-
Missing pieces in the NF-κB puzzle
-
Ghosh S., and Karin M. Missing pieces in the NF-κB puzzle. Cell 109 Suppl (2002) S81-S96
-
(2002)
Cell
, vol.109
, Issue.SUPPL
-
-
Ghosh, S.1
Karin, M.2
-
38
-
-
12544250145
-
Role for protein kinase C-θ (PKCθ) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-κB activation
-
Li Y., Sedwick C.E., Hu J., et al. Role for protein kinase C-θ (PKCθ) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-κB activation. J Biol Chem 280 (2005) 1217-1223
-
(2005)
J Biol Chem
, vol.280
, pp. 1217-1223
-
-
Li, Y.1
Sedwick, C.E.2
Hu, J.3
-
39
-
-
0029670089
-
PKCθ isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes
-
Baier-Bitterlich G., Überall F., Bauer B., et al. PKCθ isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. Mol Cell Biol 16 (1996) 1842-1850
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1842-1850
-
-
Baier-Bitterlich, G.1
Überall, F.2
Bauer, B.3
-
40
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
Shaulian E., and Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4 (2002) E131-E136
-
(2002)
Nat Cell Biol
, vol.4
-
-
Shaulian, E.1
Karin, M.2
-
42
-
-
1842524184
-
SPAK kinase is a substrate and target of PKCθ in T-cell receptor-induced AP-1 activation pathway
-
Li Y., Hu J., Vita R., et al. SPAK kinase is a substrate and target of PKCθ in T-cell receptor-induced AP-1 activation pathway. EMBO J 23 (2004) 1112-1122
-
(2004)
EMBO J
, vol.23
, pp. 1112-1122
-
-
Li, Y.1
Hu, J.2
Vita, R.3
-
43
-
-
3042645122
-
2+ signaling by PKCθ in restimulated T cells via a Tec kinase-dependent pathway
-
2+ signaling by PKCθ in restimulated T cells via a Tec kinase-dependent pathway. Eur J Immunol 34 (2004) 2001-2011
-
(2004)
Eur J Immunol
, vol.34
, pp. 2001-2011
-
-
Altman, A.1
Kaminski, S.2
Busuttil, V.3
-
44
-
-
33646560593
-
Diacylglycerol and protein kinase D localization during T lymphocyte activation
-
Spitaler M., Emslie E., Wood C.D., et al. Diacylglycerol and protein kinase D localization during T lymphocyte activation. Immunity 24 (2006) 535-546
-
(2006)
Immunity
, vol.24
, pp. 535-546
-
-
Spitaler, M.1
Emslie, E.2
Wood, C.D.3
-
45
-
-
0035474310
-
Adaptor proteins in protein kinase C-mediated signal transduction
-
Schechtman D., and Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20 (2001) 6339-6347
-
(2001)
Oncogene
, vol.20
, pp. 6339-6347
-
-
Schechtman, D.1
Mochly-Rosen, D.2
-
46
-
-
17444403210
-
The C2 domain of PKCδ is a phosphotyrosine binding domain
-
Benes C.H., Wu N., Elia A.E., et al. The C2 domain of PKCδ is a phosphotyrosine binding domain. Cell 121 (2005) 271-280
-
(2005)
Cell
, vol.121
, pp. 271-280
-
-
Benes, C.H.1
Wu, N.2
Elia, A.E.3
-
47
-
-
0034288906
-
A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation
-
Villalba M., Coudronniere N., Deckert M., et al. A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation. Immunity 12 (2000) 151-160
-
(2000)
Immunity
, vol.12
, pp. 151-160
-
-
Villalba, M.1
Coudronniere, N.2
Deckert, M.3
-
48
-
-
0037092038
-
Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
-
Villalba M., Bi K., Hu J., et al. Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol 157 (2002) 253-263
-
(2002)
J Cell Biol
, vol.157
, pp. 253-263
-
-
Villalba, M.1
Bi, K.2
Hu, J.3
-
49
-
-
0034644523
-
Cellular signaling: pivoting around PDK-1
-
Toker A., and Newton A.C. Cellular signaling: pivoting around PDK-1. Cell 103 (2000) 185-188
-
(2000)
Cell
, vol.103
, pp. 185-188
-
-
Toker, A.1
Newton, A.C.2
-
50
-
-
15944410614
-
PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation
-
Lee K.Y., D'Acquisto F., Hayden M.S., et al. PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation. Science 308 (2005) 114-118
-
(2005)
Science
, vol.308
, pp. 114-118
-
-
Lee, K.Y.1
D'Acquisto, F.2
Hayden, M.S.3
-
51
-
-
33645733203
-
Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation"
-
[author reply 55]
-
Gruber T., Freeley M., Thuille N., et al. Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation". Science 312 (2006) 55 [author reply 55]
-
(2006)
Science
, vol.312
, pp. 55
-
-
Gruber, T.1
Freeley, M.2
Thuille, N.3
-
52
-
-
0031012892
-
Determination of the specific substrate sequence motifs of protein kinase C isozymes
-
Nishikawa K., Toker A., Johannes F.-J., et al. Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem 272 (1997) 952-960
-
(1997)
J Biol Chem
, vol.272
, pp. 952-960
-
-
Nishikawa, K.1
Toker, A.2
Johannes, F.-J.3
-
53
-
-
0032571406
-
Protein kinase C-θ phosphorylation of moesin in the actin-binding sequence
-
Pietromonaco S.F., Simons P.C., Altman A., et al. Protein kinase C-θ phosphorylation of moesin in the actin-binding sequence. J Biol Chem 273 (1998) 7594-7603
-
(1998)
J Biol Chem
, vol.273
, pp. 7594-7603
-
-
Pietromonaco, S.F.1
Simons, P.C.2
Altman, A.3
-
54
-
-
18244364886
-
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse
-
Allenspach E.J., Cullinan P., Tong J., et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15 (2001) 739-750
-
(2001)
Immunity
, vol.15
, pp. 739-750
-
-
Allenspach, E.J.1
Cullinan, P.2
Tong, J.3
-
55
-
-
0035652354
-
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
-
Delon J., Kaibuchi K., and Germain R.N. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 15 (2001) 691-701
-
(2001)
Immunity
, vol.15
, pp. 691-701
-
-
Delon, J.1
Kaibuchi, K.2
Germain, R.N.3
-
56
-
-
0027509048
-
Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons
-
Yonemura S., Nagafuchi A., Sato N., et al. Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons. J Cell Biol 120 (1993) 437-449
-
(1993)
J Cell Biol
, vol.120
, pp. 437-449
-
-
Yonemura, S.1
Nagafuchi, A.2
Sato, N.3
-
57
-
-
0036928182
-
Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation
-
Sasahara Y., Rachid R., Byrne M.J., et al. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell 10 (2002) 1269-1281
-
(2002)
Mol Cell
, vol.10
, pp. 1269-1281
-
-
Sasahara, Y.1
Rachid, R.2
Byrne, M.J.3
-
58
-
-
0032118427
-
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
-
Snapper S.B., Rosen F.S., Mizoguchi E., et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 9 (1998) 81-91
-
(1998)
Immunity
, vol.9
, pp. 81-91
-
-
Snapper, S.B.1
Rosen, F.S.2
Mizoguchi, E.3
-
59
-
-
8544233570
-
Protein kinase C θ inhibits insulin signaling by phosphorylating IRS1 at Ser-1101
-
Li Y., Soos T.J., Li X., et al. Protein kinase C θ inhibits insulin signaling by phosphorylating IRS1 at Ser-1101. J Biol Chem 279 (2004) 45304-45307
-
(2004)
J Biol Chem
, vol.279
, pp. 45304-45307
-
-
Li, Y.1
Soos, T.J.2
Li, X.3
-
60
-
-
8544244084
-
PKC-θ knockout mice are protected from fat-induced insulin resistance
-
Kim J.K., Fillmore J.J., Sunshine M.J., et al. PKC-θ knockout mice are protected from fat-induced insulin resistance. J Clin Invest 114 (2004) 823-827
-
(2004)
J Clin Invest
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
Fillmore, J.J.2
Sunshine, M.J.3
-
61
-
-
0037081849
-
Phosphorylation of the protein kinase C-θ activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-κB induction
-
Liu Y., Graham C., Li A., et al. Phosphorylation of the protein kinase C-θ activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-κB induction. Biochem J 361 Pt 2 (2002) 255-265
-
(2002)
Biochem J
, vol.361
, Issue.PART 2
, pp. 255-265
-
-
Liu, Y.1
Graham, C.2
Li, A.3
-
62
-
-
27844439874
-
Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes
-
Thuille N., Heit I., Fresser F., et al. Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCθ in T lymphocytes. EMBO J 24 (2005) 3869-3880
-
(2005)
EMBO J
, vol.24
, pp. 3869-3880
-
-
Thuille, N.1
Heit, I.2
Fresser, F.3
-
63
-
-
1642299050
-
PKCθ signals activation versus tolerance in vivo
-
Berg-Brown N.N., Gronski M.A., Jones R.G., et al. PKCθ signals activation versus tolerance in vivo. J Exp Med 199 (2004) 743-752
-
(2004)
J Exp Med
, vol.199
, pp. 743-752
-
-
Berg-Brown, N.N.1
Gronski, M.A.2
Jones, R.G.3
-
65
-
-
18744364178
-
Protein kinase C θ is not essential for T-cell-mediated clearance of murine gammaherpesvirus 68
-
Giannoni F., Lyon A.B., Wareing M.D., et al. Protein kinase C θ is not essential for T-cell-mediated clearance of murine gammaherpesvirus 68. J Virol 79 (2005) 6808-6813
-
(2005)
J Virol
, vol.79
, pp. 6808-6813
-
-
Giannoni, F.1
Lyon, A.B.2
Wareing, M.D.3
-
66
-
-
3242790172
-
Protein kinase C θ Is critical for the development of in vivo T helper Th2 cell but not Th1 cell responses
-
Marsland B.J., Soos T.J., Spath G., et al. Protein kinase C θ Is critical for the development of in vivo T helper Th2 cell but not Th1 cell responses. J Exp Med 200 (2004) 181-189
-
(2004)
J Exp Med
, vol.200
, pp. 181-189
-
-
Marsland, B.J.1
Soos, T.J.2
Spath, G.3
-
67
-
-
8444243253
-
Differential regulation of Th2 and Th1 lung inflammatory responses by PKCθ
-
Salek-Ardakani S., So T., Halteman B.S., et al. Differential regulation of Th2 and Th1 lung inflammatory responses by PKCθ. J Immunol 173 (2004) 6440-6447
-
(2004)
J Immunol
, vol.173
, pp. 6440-6447
-
-
Salek-Ardakani, S.1
So, T.2
Halteman, B.S.3
-
68
-
-
9644262463
-
Signaling pathways in Th2 development
-
Mowen K.A., and Glimcher L.H. Signaling pathways in Th2 development. Immunol Rev 202 (2004) 203-222
-
(2004)
Immunol Rev
, vol.202
, pp. 203-222
-
-
Mowen, K.A.1
Glimcher, L.H.2
-
69
-
-
33845589222
-
Involvement of GATA3 in protein kinase C θ-induced Th2 cytokine expression
-
Stevens L., Htut T.M., White D., et al. Involvement of GATA3 in protein kinase C θ-induced Th2 cytokine expression. Eur J Immunol 36 (2006) 3305-3314
-
(2006)
Eur J Immunol
, vol.36
, pp. 3305-3314
-
-
Stevens, L.1
Htut, T.M.2
White, D.3
-
70
-
-
28244464872
-
Protein kinase Cθ controls Th1 cells in experimental autoimmune encephalomyelitis
-
Salek-Ardakani S., So T., Halteman B.S., et al. Protein kinase Cθ controls Th1 cells in experimental autoimmune encephalomyelitis. J Immunol 175 (2005) 7635-7641
-
(2005)
J Immunol
, vol.175
, pp. 7635-7641
-
-
Salek-Ardakani, S.1
So, T.2
Halteman, B.S.3
-
71
-
-
33644512418
-
Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C θ-deficient mice
-
Tan S.L., Zhao J., Bi C., et al. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C θ-deficient mice. J Immunol 176 (2006) 2872-2879
-
(2006)
J Immunol
, vol.176
, pp. 2872-2879
-
-
Tan, S.L.1
Zhao, J.2
Bi, C.3
-
72
-
-
33750036982
-
Mice deficient in PKC θ demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases
-
Anderson K., Fitzgerald M., Dupont M., et al. Mice deficient in PKC θ demonstrate impaired in vivo T cell activation and protection from T cell-mediated inflammatory diseases. Autoimmunity 39 (2006) 469-478
-
(2006)
Autoimmunity
, vol.39
, pp. 469-478
-
-
Anderson, K.1
Fitzgerald, M.2
Dupont, M.3
-
73
-
-
33746210212
-
PKC-θ-deficient mice are protected from Th1-dependent antigen-induced arthritis
-
Healy A.M., Izmailova E., Fitzgerald M., et al. PKC-θ-deficient mice are protected from Th1-dependent antigen-induced arthritis. J Immunol 177 (2006) 1886-1893
-
(2006)
J Immunol
, vol.177
, pp. 1886-1893
-
-
Healy, A.M.1
Izmailova, E.2
Fitzgerald, M.3
-
74
-
-
33646164439
-
Expanding the effector CD4 T-cell repertoire: the Th17 lineage
-
Harrington L.E., Mangan P.R., and Weaver C.T. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 18 (2006) 349-356
-
(2006)
Curr Opin Immunol
, vol.18
, pp. 349-356
-
-
Harrington, L.E.1
Mangan, P.R.2
Weaver, C.T.3
-
75
-
-
33744984785
-
Th17: an effector CD4 T cell lineage with regulatory T cell ties
-
Weaver C.T., Harrington L.E., Mangan P.R., et al. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24 (2006) 677-688
-
(2006)
Immunity
, vol.24
, pp. 677-688
-
-
Weaver, C.T.1
Harrington, L.E.2
Mangan, P.R.3
-
76
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E., Carrier Y., Gao W., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
77
-
-
9644295708
-
Issues in T-helper 1 development-resolved and unresolved
-
Berenson L.S., Ota N., and Murphy K.M. Issues in T-helper 1 development-resolved and unresolved. Immunol Rev 202 (2004) 157-174
-
(2004)
Immunol Rev
, vol.202
, pp. 157-174
-
-
Berenson, L.S.1
Ota, N.2
Murphy, K.M.3
-
78
-
-
1842480966
-
+ regulatory and natural killer-like T cells on signals leading to NF-κB activation
-
+ regulatory and natural killer-like T cells on signals leading to NF-κB activation. Proc Natl Acad Sci USA 101 (2004) 4566-4571
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4566-4571
-
-
Schmidt-Supprian, M.1
Tian, J.2
Grant, E.P.3
-
80
-
-
0034711239
-
PKC-θ and ε promote T cell survival by a Rsk-dependent phosphorylation and inactivation of BAD
-
Bertolotto C., Maulon L., Filippa N., et al. PKC-θ and ε promote T cell survival by a Rsk-dependent phosphorylation and inactivation of BAD. J Biol Chem 275 (2000) 37246-37250
-
(2000)
J Biol Chem
, vol.275
, pp. 37246-37250
-
-
Bertolotto, C.1
Maulon, L.2
Filippa, N.3
-
81
-
-
0035873711
-
PKCθ mediates a selective T cell survival signal via phosphorylation of BAD
-
Villalba M., Bushway P., and Altman A. PKCθ mediates a selective T cell survival signal via phosphorylation of BAD. J Immunol 166 (2001) 5955-5963
-
(2001)
J Immunol
, vol.166
, pp. 5955-5963
-
-
Villalba, M.1
Bushway, P.2
Altman, A.3
-
82
-
-
33846346546
-
Raf-1 and B-Raf promote protein kinase C theta interaction with BAD
-
Hindley A., and Kolch W. Raf-1 and B-Raf promote protein kinase C theta interaction with BAD. Cell Signal 19 (2006) 547-555
-
(2006)
Cell Signal
, vol.19
, pp. 547-555
-
-
Hindley, A.1
Kolch, W.2
-
84
-
-
0033010882
-
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
-
Zhou T., Song L., Yang P., et al. Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. Nat Med 5 (1999) 42-48
-
(1999)
Nat Med
, vol.5
, pp. 42-48
-
-
Zhou, T.1
Song, L.2
Yang, P.3
-
85
-
-
0036285316
-
Protein kinase C-theta (PKC-theta), an example of a drug target for therapeutic intervention with human T cell leukemias
-
Villalba M., and Altman A. Protein kinase C-theta (PKC-theta), an example of a drug target for therapeutic intervention with human T cell leukemias. Curr Cancer Drug Targets 2 (2002) 125-134
-
(2002)
Curr Cancer Drug Targets
, vol.2
, pp. 125-134
-
-
Villalba, M.1
Altman, A.2
|