Involvement of Rel, Fos, and Jun Proteins in Binding Activity to the IL-2 Promoter CD28 Response Element/AP-1 Sequence in Human T Cells

Journal of Immunology

Volumn 159, Issue 3, 1997, Pages 1319-1327

  McGuire, Kathleen L ^a,b   Iacobelli, Milena ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; DNA BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROMOTER REGION; T LYMPHOCYTE;

ANTIGENS, CD28; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 0031204429     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045.
2. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
3. June, C. H., J. A. Ledbetter, M. M. Gillespie, T. Lindsten, and C. B. Thompson. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporin-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7:4472.
4. Thompson, C. B., L. Lindsten, J. A. Ledbetter, S. L. Kunkel, H. A. Young, S. G. Emerson, J. M. Leiden, and C. H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86:1333.
5. Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
6. Fraser, J. D., and A. Weiss. 1992. Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Mol. Cell. Biol. 12:4357.
7. Umlauf, S. W., B. Beverly, O. Lantz, and R. H. Schwartz. 1995. Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol. Cell. Biol. 15:3197.
8. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T-lymphocytes. Cell 77:727.
9. Bryan, R. G., Y. Li, J.-H. Lai, M. Van, N. R. Rice, R. R. Rich, and T.-H. Tan. 1994. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol. Cell. Biol. 14:7933.
10. Lai, J.-H., and T.-H. Tan. 1994. CD28 signaling causes a sustained down-regulation of IκBα which can be prevented by the immunosuppressant rapamycin. J. Biol. Chem. 269:30077.
11. Romano, M. F., R. Bisogni, A. Lamberti, M. C. Turco, A. Petrella, P. Tassone, R. Van Lier, S. Formisano, and S. Venuta. 1994. Regulation of NF-κB nuclear activity in peripheral blood mononuclear cells: role of CD28 antigen. Cell. Immunol. 156:371.
12. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
13. Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
14. Verweij, C. L., M. Geerts, and L. A. Aarden. 1991. Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-κB-like response element. J. Biol. Chem. 266:14179.
15. Civil, A., M. Geerts, L. A. Aarden, and C. L. Verweij. 1992. Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals. Eur. J. Immunol. 22:3041.
16. June, C. H., J. A. Ledbetter, T. Lindsten, and C. B. Thompson. 1989. Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes. J. Immunol. 143:153.
17. Schreiber, S. L., and G. R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13:136.
18. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723.
19. Stein, B., A. S. Baldwin Jr., D. W. Ballard, W. C. Greene, A. Angel, and P. Herrlich. 1993. Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J. 12:3879.
20. Stein, B., and A. S. Baldwin. Jr. 1993. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol. Cell. Biol. 13:7191.
21. Stein, B., P. C. Cogswell, and A. S. Baldwin. 1993. Functional and physical associations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol. 13:3964.
22. Dunn, S. M., L. S. Coles, R. K. Lang, S. Gerondakis, M. A. Vadas, and M. F. Shannon. 1994. Requirement for nuclear factor (NF)-κB p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter. Blood 83:2469.
23. Kunsch, C., R. K. Lang, C. A. Rosen, and M. F. Shannon. 1994. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (Rel A) and NF-IL-6. J. Immunol. 153:153.
24. Ghosh, P., T. Tan, N. R. Rice, A. Sica, and H. A. Young. 1993. The interleukin 2 CD28-responsive complex contains at least three members of the NF-κB family: c-Rel, p50, and p65. Proc. Natl. Acad. Sci. USA 90:1696.
25. Lai, J.-H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T.-H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol. Cell. Biol. 15:4260.
26. Li, M., and M. Siekevitz. 1993. A cis element required for induction of the interleukin 2 enhancer by human T-cell leukemia virus type I binds a novel Tax-inducible nuclear protein. Mol. Cell. Biol. 13:6490.
27. Civil, A., A. Bakker, I. Rensink, S. Doerre, L. A. Aarden, and C. L. Verweij. 1996. Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production. J. Biol. Chem. 271:8321.
28. Rooney, J. W., Y.-L. Sun, L. H. Glimcher, and T. Hoey. 1995. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell. Biol. 15:6299.
29. Franchini, G. 1995. Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection. Blood 86:3619.
30. McGuire, K. L., V. C. Curtiss, E. L. Larson, and W. A. Haseltine. 1993. Influence of human T-cell leukemia virus type I tax and rex on interleukin-2 gene expression. J. Virol. 67:1590.
31. Good, L., S. B. Maggirwar, and S.-C. Sun. 1996. Activation of the IL-2 gene promoter by HTLV-I Tax involves induction of NF-AT complexes bound to the CD28-response element. EMBO J. 15:3744.
32. Curtiss, V. E., R. Smilde, and K. L. McGuire. 1996. Requirements for interleukin 2 promoter transactivation by the Tax protein of human T-cell leukemia virus type I. Mol. Cell. Biol. 16:3567.
33. Cullen, B. R. 1987. Use of eukaryotic technology in the functional analysis of cloned genes. Methods Enzymol. 152:684.
34. Chen, D., and E. V. Rothenberg. 1993. Molecular basis for developmental changes in interleukin-2 gene inducibility. Mol. Cell. Biol. 13:228.
35. Rice, N. R., M. L. MacKichan, and A. Israel. 1992. The precursor of NF-κB p50 has IκB-like functions. Cell 71:243.
36. Neumann, M., K. Tsapos, J. A. Scheppler, J. Ross, and B. R. J. Franza. 1992. Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-κB. Oncogene 7:2095.
37. Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
38. Gerondakis, S., A. Strasser, D. Metcalf, G. Grigoriadis, J.-P. Y. Scheerlinck, and R. J. Grumont. 1996. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 93:3405.
39. Shannon, M. F., S. R. Himes, and L. S. Coles. 1995. GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells. J. Leuk. Biol. 57:767.
40. Wang, W., W. F. Tam, C. C. W. Hughes, S. Rath, and R. Sen. 1997. c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. Immunity 6:165.
41. Li, C.-C. H., F. W. Ruscetti, N. R. Rice, E. Chen, N.-S. Yang, J. Mikovits, and D. L. Longo. 1993. Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein. J. Virol. 67:4205.
42. Sun, S. C., J. Elwood, C. Beraud, and W. C. Greene. 1994. Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol. Cell. Biol. 14:7377.
43. Suzuki, T., H. Hirai, and M. Yoshida. 1994. Tax protein of HTLV-1 interacts with the Rel homology domain of NF-κB p65 and c-Rel proteins bound to the NF-κB binding site and activates transcription. Oncogene 9:3099.
44. Baranger, A. M., C. R. Palmer, M. K. Hamm, H. A. Giebler, A. Brauweiler, J. K. Nyborg, and A. Schepartz. 1995. Mechanism of DNA-binding enhancement by the human T-cell leukemia virus transactivator Tax. Nature 376:606.
45. Perini, G., S. Wagner, and M. R. Green. 1995. Recognition of bZIP proteins by the human T-cell leukemia virus transactivator Tax. Nature 376:602.