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Volumn 16, Issue 3, 2004, Pages 374-381

T-cell-receptor- and B-cell-receptor-mediated activation of NF-κB in lymphocytes

Author keywords

B cell receptor; B cell adaptor for PI3K; BCAP; BCR; Bruton's tyrosine kinase; Btk; c Jun amino terminal kinase; CARD; CARD MAGUK1; Carma1; caspase recruitment domain; I B; I B kinase; IKK; IL; inhibitor of B; interleukin; JNK; LAT

Indexed keywords

B LYMPHOCYTE RECEPTOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 10; T LYMPHOCYTE RECEPTOR;

EID: 2342611054     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.03.003     Document Type: Review
Times cited : (105)

References (58)
  • 1
    • 0034175930 scopus 로고    scopus 로고
    • The IKK complex: An integrator of all signals that activate NF-κB?
    • Israël A. The IKK complex: an integrator of all signals that activate NF-κB? Trends Cell Biol. 10:2000;129-133
    • (2000) Trends Cell Biol , vol.10 , pp. 129-133
    • Israël, A.1
  • 2
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh S., Karin M. Missing pieces in the NF-κB puzzle. Cell. 109:2002;S81-S96
    • (2002) Cell , vol.109 , pp. 81-S96
    • Ghosh, S.1    Karin, M.2
  • 4
    • 0035339837 scopus 로고    scopus 로고
    • ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappaB activation in response to engagement of CD3 and CD28
    • Herndon T.M., Shan X.C., Tsokos G.C., Wange R.L. ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappaB activation in response to engagement of CD3 and CD28. J Immunol. 166:2001;5654-5664
    • (2001) J Immunol , vol.166 , pp. 5654-5664
    • Herndon, T.M.1    Shan, X.C.2    Tsokos, G.C.3    Wange, R.L.4
  • 5
  • 6
    • 85047682875 scopus 로고    scopus 로고
    • Protein kinase C theta in T cell activation
    • Isakov N., Altman A. Protein kinase C theta in T cell activation. Annu Rev Immunol. 20:2002;761-794
    • (2002) Annu Rev Immunol , vol.20 , pp. 761-794
    • Isakov, N.1    Altman, A.2
  • 8
    • 0038620475 scopus 로고    scopus 로고
    • Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cells
    • •] report the analysis of PKCθ-deficient mice, but present conflicting data regarding the role of this kinase in NF-κB and NFAT signalling.
    • •] report the analysis of PKCθ-deficient mice, but present conflicting data regarding the role of this kinase in NF-κB and NFAT signalling.
    • (2003) J Exp Med , vol.197 , pp. 1525-1535
    • Pfeifhofer, C.1    Kofler, K.2    Gruber, T.3    Tabrizi, N.G.4    Lutz, C.5    Maly, K.6    Leitges, M.7    Baier, G.8
  • 11
    • 0037092038 scopus 로고    scopus 로고
    • Translocation of PKC-theta in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
    • Villalba M., Bi K., Hu J., Altman Y., Bushway P., Reits E., Neefjes J., Baier G., Abraham R.T., Altman A. Translocation of PKC-theta in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J Cell Biol. 157:2002;253-263
    • (2002) J Cell Biol , vol.157 , pp. 253-263
    • Villalba, M.1    Bi, K.2    Hu, J.3    Altman, Y.4    Bushway, P.5    Reits, E.6    Neefjes, J.7    Baier, G.8    Abraham, R.T.9    Altman, A.10
  • 12
    • 0034602963 scopus 로고    scopus 로고
    • Regulation of protein kinase C-theta function during T cell activation by Lck-mediated tyrosine phosphorylation
    • Liu Y., Witte S., Liu Y.C., Doyle M., Elly C., Altman A. Regulation of protein kinase C-theta function during T cell activation by Lck-mediated tyrosine phosphorylation. J Biol Chem. 275:2000;3603-3609
    • (2000) J Biol Chem , vol.275 , pp. 3603-3609
    • Liu, Y.1    Witte, S.2    Liu, Y.C.3    Doyle, M.4    Elly, C.5    Altman, A.6
  • 13
    • 0034288906 scopus 로고    scopus 로고
    • A novel functional interaction between Vav and PKC-theta is required for TCR-induced T cell activation
    • Villalba M., Coudronniere N., Deckert M., Teixeiro E., Mas P., Altman A. A novel functional interaction between Vav and PKC-theta is required for TCR-induced T cell activation. Immunity. 12:2000;151-160
    • (2000) Immunity , vol.12 , pp. 151-160
    • Villalba, M.1    Coudronniere, N.2    Deckert, M.3    Teixeiro, E.4    Mas, P.5    Altman, A.6
  • 14
    • 0034724201 scopus 로고    scopus 로고
    • NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
    • Coudronniere N., Villalba M., Englund N., Altman A. NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta. Proc Natl Acad Sci USA. 97:2000;3394-3399
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3394-3399
    • Coudronniere, N.1    Villalba, M.2    Englund, N.3    Altman, A.4
  • 15
    • 0034031401 scopus 로고    scopus 로고
    • Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta
    • Lin X., O'Mahony A., Mu Y., Geleziunas R., Greene W.C. Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta. Mol Cell Biol. 20:2000;2933-2940
    • (2000) Mol Cell Biol , vol.20 , pp. 2933-2940
    • Lin, X.1    O'Mahony, A.2    Mu, Y.3    Geleziunas, R.4    Greene, W.C.5
  • 16
    • 0037237205 scopus 로고    scopus 로고
    • The immunological synapse and actin assembly: A regulatory role for PKC theta
    • Thome M. The immunological synapse and actin assembly: a regulatory role for PKC theta. Dev Cell. 4:2003;3-5
    • (2003) Dev Cell , vol.4 , pp. 3-5
    • Thome, M.1
  • 17
    • 0036928182 scopus 로고    scopus 로고
    • Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation
    • This elegant study shows that the WASP-interacting protein (WIP) inhibitor of Wiskott-Aldrich syndrome protein (WASP), a molecule involved in F actin polymerisation, is a substrate of PKCθ. Through this process, PKCθ induces dissociation of WASP from a ZAP-70-CrkL-WIP-WASP complex localized in the immunological synapse.
    • Sasahara Y., Rachid R., Byrne M.J., de la Fuente M.A., Abraham R.T., Ramesh N., Geha R.S. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell. 10:2002;1269-1281 This elegant study shows that the WASP-interacting protein (WIP) inhibitor of Wiskott-Aldrich syndrome protein (WASP), a molecule involved in F actin polymerisation, is a substrate of PKCθ. Through this process, PKCθ induces dissociation of WASP from a ZAP-70-CrkL-WIP-WASP complex localized in the immunological synapse.
    • (2002) Mol Cell , vol.10 , pp. 1269-1281
    • Sasahara, Y.1    Rachid, R.2    Byrne, M.J.3    De La Fuente, M.A.4    Abraham, R.T.5    Ramesh, N.6    Geha, R.S.7
  • 19
    • 0042346187 scopus 로고    scopus 로고
    • B cell receptor-mediated Syk-independent activation of phosphatidylinositol 3-kinase, Ras, and mitogen-activated protein kinase pathways
    • Yokozeki T., Adler K., Lankar D., Bonnerot C. B cell receptor-mediated Syk-independent activation of phosphatidylinositol 3-kinase, Ras, and mitogen-activated protein kinase pathways. J Immunol. 171:2003;1328-1335
    • (2003) J Immunol , vol.171 , pp. 1328-1335
    • Yokozeki, T.1    Adler, K.2    Lankar, D.3    Bonnerot, C.4
  • 20
    • 0042922816 scopus 로고    scopus 로고
    • Coupling between B cell receptor and phospholipase C-gamma2 is essential for mature B cell development
    • Hikida M., Johmura S., Hashimoto A., Takezaki M., Kurosaki T. Coupling between B cell receptor and phospholipase C-gamma2 is essential for mature B cell development. J Exp Med. 198:2003;581-589
    • (2003) J Exp Med , vol.198 , pp. 581-589
    • Hikida, M.1    Johmura, S.2    Hashimoto, A.3    Takezaki, M.4    Kurosaki, T.5
  • 21
    • 0035827623 scopus 로고    scopus 로고
    • The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-kappaB and cell cycle entry and survival of B lymphocytes
    • Tan J.E., Wong S.C., Gan S.K., Xu S., Lam K.P. The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-kappaB and cell cycle entry and survival of B lymphocytes. J Biol Chem. 276:2001;20055-20063
    • (2001) J Biol Chem , vol.276 , pp. 20055-20063
    • Tan, J.E.1    Wong, S.C.2    Gan, S.K.3    Xu, S.4    Lam, K.P.5
  • 22
    • 0034987582 scopus 로고    scopus 로고
    • Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase
    • Khan W.N. Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase. Immunol Res. 23:2001;147-156
    • (2001) Immunol Res , vol.23 , pp. 147-156
    • Khan, W.N.1
  • 23
    • 0036344276 scopus 로고    scopus 로고
    • PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
    • This paper shows that PKCβ is required for BCR-mediated NF-κB activation, and that it controls the recruitment of the IκB kinase complex into lipid rafts.
    • Su T.T., Guo B., Kawakami Y., Sommer K., Chae K., Humphries L.A., Kato R.M., Kang S., Patrone L., Wall R., et al. PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol. 3:2002;780-786 This paper shows that PKCβ is required for BCR-mediated NF-κB activation, and that it controls the recruitment of the IκB kinase complex into lipid rafts.
    • (2002) Nat Immunol , vol.3 , pp. 780-786
    • Su, T.T.1    Guo, B.2    Kawakami, Y.3    Sommer, K.4    Chae, K.5    Humphries, L.A.6    Kato, R.M.7    Kang, S.8    Patrone, L.9    Wall, R.10
  • 25
    • 0037124307 scopus 로고    scopus 로고
    • Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha
    • Saijo K., Mecklenbrauker I., Santana A., Leitger M., Schmedt C., Tarakhovsky A. Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha. J Exp Med. 195:2002;1647-1652
    • (2002) J Exp Med , vol.195 , pp. 1647-1652
    • Saijo, K.1    Mecklenbrauker, I.2    Santana, A.3    Leitger, M.4    Schmedt, C.5    Tarakhovsky, A.6
  • 26
    • 0037443519 scopus 로고    scopus 로고
    • CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappaB
    • Mizuno T., Rothstein T.L. CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappaB. J Immunol. 170:2003;2806-2810
    • (2003) J Immunol , vol.170 , pp. 2806-2810
    • Mizuno, T.1    Rothstein, T.L.2
  • 28
    • 0036682655 scopus 로고    scopus 로고
    • Role of zeta-PKC in B-cell signaling and function
    • •,29] demonstrate that PKCζ deficiency results in defective transactivating potential of NF-κB, and selectively impairs signalling through the BCR.
    • •, 29] demonstrate that PKCζ deficiency results in defective transactivating potential of NF-κB, and selectively impairs signalling through the BCR.
    • (2002) EMBO J , vol.21 , pp. 4049-4057
    • Martin, P.1    Duran, A.2    Minguet, S.3    Gaspar, M.L.4    Diaz-Meco, M.T.5    Rennert, P.6    Leitges, M.7    Moscat, J.8
  • 30
    • 0041695162 scopus 로고    scopus 로고
    • Contribution of BCAP to maintenance of mature B cells through c-Rel
    • Yamazaki T., Kurosaki T. Contribution of BCAP to maintenance of mature B cells through c-Rel. Nat Immunol. 4:2003;780-786
    • (2003) Nat Immunol , vol.4 , pp. 780-786
    • Yamazaki, T.1    Kurosaki, T.2
  • 32
    • 0041381357 scopus 로고    scopus 로고
    • Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
    • ••] present genetic evidence that Bcl10 is implicated in antigen receptor and PMA/ionomycin-induced NF-κB activation, and is essential for the development of all mature B-cell subsets.
    • ••] present genetic evidence that Bcl10 is implicated in antigen receptor and PMA/ionomycin-induced NF-κB activation, and is essential for the development of all mature B-cell subsets.
    • (2003) Nat Immunol , vol.4 , pp. 857-865
    • Xue, L.1    Morris, S.W.2    Orihuela, C.3    Tuomanen, E.4    Cui, X.5    Wen, R.6    Wang, D.7
  • 33
    • 0035853841 scopus 로고    scopus 로고
    • CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappaB
    • Bertin J., Wang L., Guo Y., Jacobson M.D., Poyet J.L., Srinivasula S.M., Merriam S., DiStefano P.S., Alnemri E.S. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappaB. J Biol Chem. 276:2001;11877-11882
    • (2001) J Biol Chem , vol.276 , pp. 11877-11882
    • Bertin, J.1    Wang, L.2    Guo, Y.3    Jacobson, M.D.4    Poyet, J.L.5    Srinivasula, S.M.6    Merriam, S.7    Distefano, P.S.8    Alnemri, E.S.9
  • 34
    • 0035843970 scopus 로고    scopus 로고
    • Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation
    • Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. FEBS Lett. 496:2001;121-127
    • (2001) FEBS Lett , vol.496 , pp. 121-127
    • Gaide, O.1    Martinon, F.2    Micheau, O.3    Bonnet, D.4    Thome, M.5    Tschopp, J.6
  • 36
    • 0035877776 scopus 로고    scopus 로고
    • Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappaB
    • Wang L., Guo Y., Huang W.J., Ke X., Poyet J.L., Manji G.A., Merriam S., Glucksmann M.A., DiStefano P.S., Alnemri E.S., et al. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappaB. J Biol Chem. 276:2001;21405-21409
    • (2001) J Biol Chem , vol.276 , pp. 21405-21409
    • Wang, L.1    Guo, Y.2    Huang, W.J.3    Ke, X.4    Poyet, J.L.5    Manji, G.A.6    Merriam, S.7    Glucksmann, M.A.8    Distefano, P.S.9    Alnemri, E.S.10
  • 39
    • 0036707520 scopus 로고    scopus 로고
    • A requirement for CARMA1 in TCR-induced NF-kappaB activation
    • ••] present the first evidence that CARMA1 is critically involved in TCR-mediated NF-κB activation, and that it controls the subcellular localisation of Bcl10.
    • ••] present the first evidence that CARMA1 is critically involved in TCR-mediated NF-κB activation, and that it controls the subcellular localisation of Bcl10.
    • (2002) Nat Immunol , vol.3 , pp. 830-835
    • Wang, D.1    You, Y.2    Case, S.M.3    McAllister-Lucas, L.M.4    Wang, L.5    Distefano, P.S.6    Nunez, G.7    Bertin, J.8    Lin, X.9
  • 40
    • 0036790507 scopus 로고    scopus 로고
    • CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex
    • Pomerantz J.L., Denny E.M., Baltimore D. CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J. 21:2002;5184-5194
    • (2002) EMBO J , vol.21 , pp. 5184-5194
    • Pomerantz, J.L.1    Denny, E.M.2    Baltimore, D.3
  • 42
    • 0037827638 scopus 로고    scopus 로고
    • Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
    • ••] demonstrate, through a genetic approach, that CARMA1 is essential for antigen-receptor-induced NF-κB activation and lymphocyte proliferation.
    • ••] demonstrate, through a genetic approach, that CARMA1 is essential for antigen-receptor-induced NF-κB activation and lymphocyte proliferation.
    • (2003) Immunity , vol.18 , pp. 751-762
    • Jun, J.E.1    Wilson, L.E.2    Vinuesa, C.G.3    Lesage, S.4    Blery, M.5    Miosge, L.A.6    Cook, M.C.7    Kucharska, E.M.8    Hara, H.9    Penninger, J.M.10
  • 43
    • 0242708772 scopus 로고    scopus 로고
    • Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
    • Jun J.E., Goodnow C.C. Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling. Nat Immunol. 4:2003;1057-1064
    • (2003) Nat Immunol , vol.4 , pp. 1057-1064
    • Jun, J.E.1    Goodnow, C.C.2
  • 44
    • 0035374349 scopus 로고    scopus 로고
    • Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappaB signaling pathway
    • Lucas P.C., Yonezumi M., Inohara N., McAllister-Lucas L.M., Abazeed M.E., Chen F.F., Yamaoka S., Seto M., Nunez G. Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappaB signaling pathway. J Biol Chem. 276:2001;19012-19019
    • (2001) J Biol Chem , vol.276 , pp. 19012-19019
    • Lucas, P.C.1    Yonezumi, M.2    Inohara, N.3    McAllister-Lucas, L.M.4    Abazeed, M.E.5    Chen, F.F.6    Yamaoka, S.7    Seto, M.8    Nunez, G.9
  • 45
    • 0033638182 scopus 로고    scopus 로고
    • Identification of paracaspases and metacaspases: Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
    • Uren A.G., O'Rourke K., Aravind L.A., Pisabarro M.T., Seshagiri S., Koonin E.V., Dixit V.M. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell. 6:2000;961-967
    • (2000) Mol Cell , vol.6 , pp. 961-967
    • Uren, A.G.1    O'Rourke, K.2    Aravind, L.A.3    Pisabarro, M.T.4    Seshagiri, S.5    Koonin, E.V.6    Dixit, V.M.7
  • 47
    • 0345358541 scopus 로고    scopus 로고
    • Differential requirement for Malt1 in T and B cell antigen receptor signaling
    • •] present genetic evidence for the role of MALT1 in TCR-induced NF-κB activation. However, conflicting data are presented regarding the activation of NF-κB through the BCR.
    • •] present genetic evidence for the role of MALT1 in TCR-induced NF-κB activation. However, conflicting data are presented regarding the activation of NF-κB through the BCR.
    • (2003) Immunity , vol.19 , pp. 749-758
    • Ruland, J.1    Duncan, G.S.2    Wakeham, A.3    Mak, T.W.4
  • 48
    • 0345826149 scopus 로고    scopus 로고
    • Bcl10 activates NF-kappaB pathway through paracaspase/MALT1 dependent ubiquitination of NEMO/IKKgamma
    • This study demonstrates that Bcl10 induces NEMO ubiquitination in a MALT1-dependent manner, and that this event is required for TCR-induced NF-κB activation.
    • Zhou H., Wertz I., O'Rourke K., Ultsch M., Xiao W., Dixit V.M. Bcl10 activates NF-kappaB pathway through paracaspase/MALT1 dependent ubiquitination of NEMO/IKKgamma. Nature. 427:2004;167-171 This study demonstrates that Bcl10 induces NEMO ubiquitination in a MALT1-dependent manner, and that this event is required for TCR-induced NF-κB activation.
    • (2004) Nature , vol.427 , pp. 167-171
    • Zhou, H.1    Wertz, I.2    O'Rourke, K.3    Ultsch, M.4    Xiao, W.5    Dixit, V.M.6
  • 52
    • 0347093172 scopus 로고    scopus 로고
    • Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation
    • Ruefli-Brasse A.A., Lee W.P., Hurst S., Dixit V.M. Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation. J Biol Chem. 279:2004;1570-1574
    • (2004) J Biol Chem , vol.279 , pp. 1570-1574
    • Ruefli-Brasse, A.A.1    Lee, W.P.2    Hurst, S.3    Dixit, V.M.4
  • 53
    • 0037208074 scopus 로고    scopus 로고
    • Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor
    • This paper demonstrates that NEMO is normally recruited to the activated TCR at the immunological synapse. Artificial targeting of NEMO to the TCR in a ZAP-70-deficient T-cell line is sufficient to specifically restore NF-κB activation in response to anti-CD3. In addition, it shows that the presence of NEMO at the cell membrane is sufficient to induce NF-κB activation.
    • Weil R., Schwamborn K., Alcover A., Bessia C., Di Bartolo V., Israël A. Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor. Immunity. 18:2003;13-26 This paper demonstrates that NEMO is normally recruited to the activated TCR at the immunological synapse. Artificial targeting of NEMO to the TCR in a ZAP-70-deficient T-cell line is sufficient to specifically restore NF-κB activation in response to anti-CD3. In addition, it shows that the presence of NEMO at the cell membrane is sufficient to induce NF-κB activation.
    • (2003) Immunity , vol.18 , pp. 13-26
    • Weil, R.1    Schwamborn, K.2    Alcover, A.3    Bessia, C.4    Di Bartolo, V.5    Israël, A.6
  • 55
    • 0037220660 scopus 로고    scopus 로고
    • Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappaB activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation
    • Dienz O., Moller A., Strecker A., Stephan N., Krammer P.H., Droge W., Schmitz M.L. Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappaB activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation. J Immunol. 170:2003;365-372
    • (2003) J Immunol , vol.170 , pp. 365-372
    • Dienz, O.1    Moller, A.2    Strecker, A.3    Stephan, N.4    Krammer, P.H.5    Droge, W.6    Schmitz, M.L.7
  • 56
    • 0034657235 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation
    • Bajpai U.D., Zhang K., Teutsch M., Sen R., Wortis H.H. Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med. 191:2000;1735-1744
    • (2000) J Exp Med , vol.191 , pp. 1735-1744
    • Bajpai, U.D.1    Zhang, K.2    Teutsch, M.3    Sen, R.4    Wortis, H.H.5
  • 57
    • 0034657307 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement
    • Petro J.B., Rahman S.M., Ballard D.W., Khan W.N. Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med. 191:2000;1745-1754
    • (2000) J Exp Med , vol.191 , pp. 1745-1754
    • Petro, J.B.1    Rahman, S.M.2    Ballard, D.W.3    Khan, W.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.