Alcohol intake modulates the genetic association between HDL cholesterol and the PPARγ2 Pro12Ala polymorphism

Journal of Lipid Research

Volumn 46, Issue 5, 2005, Pages 913-919

  Brand Herrmann, Stefan Martin ^a   Kuznetsova, Tatiana ^b,c   Wiechert, Andreas ^d   Stolarz, Katarzyna ^b,e   Tikhonoff, Valerie ^f   Schmidt Petersen, Klaus ^a   Telgmann, Ralph ^a   Casiglia, Edoardo ^f   Wang, Ji Guang ^b   Thijs, Lutgarde ^b   Staessen, Jan A ^b   Brand, Eva ^d,g  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c NOVOSIBIRSK STATE MEDICAL UNIVERSITY   (Russian Federation)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e JAGIELLONIAN UNIVERSITY   (Poland)

^f UNIVERSITY OF PADOVA   (Italy)

^g UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Genotype alcohol interaction; High density lipoprotein cholesterol; Peroxisome proliferator activated receptor 2

Indexed keywords

ALANINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PROLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLIC BEVERAGE; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DRINKING BEHAVIOR; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HOMOZYGOSITY; HUMAN; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; CHEMISTRY; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED;

ADULT; ALANINE; ALCOHOL DRINKING; ALLELES; CHOLESTEROL, HDL; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; PPAR GAMMA; PROLINE;

EID: 27244447175     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M400405-JLR200     Document Type: Article

References (26)

1. Genest, J., M. Marcil, M. Denis, and L. Yu. 1999. High density lipoproteins in health and disease. J. Invest. Med. 47: 31-42.
2. Stein, O., and Y. Stein. 1999. Atheroprotective mechanisms of HDL. Atherosclerosis. 144: 285-303.
3. Gordon, D. J., and B. M. Rifkind. 1989. High-density lipoprotein - the clinical implications of recent studies. N. Engl. J. Med. 321: 1311-1316.
4. Hegele, R. A. 2001. Monogenic dyslipidemias: window on determia nants of plasma lipoprotein metabolism. Am. J. Hum. Genet. 69: 1161-1177.
5. Akiyama, T. E., S. Sakai, G. Lambert, C. J. Nicol, K. Matsusue, S. Pimprale, Y. H. Lee, M. Ricote, C. K. Glass, H. B. Brewer, Jr., et al. 2002. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol. Cell. Biol. 22: 2607-2619.
6. Knoblauch, H., A. Busjahn, B. Muller-Myhsok, H. D. Faulhaber, H. Schuster, R. Uhlmann, and F. C. Luft. 1999. Peroxisome proliferator-activated receptor gamma gene locus is related to body mass index and lipid values in healthy nonobese subjects. Arterioscler. Thromb. Vasc. Biol. 19: 2940-2944.
7. Deeb, S., L. Fajas, M. Nemoto, J. Pihlajamaki, L. Mykkanen, J. Kuusisto, M. Laakso, W. Fujimoto, and J. Auwerx. 1998. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet. 20: 284-287.
8. Pihlajamaki, J., R. Miettinen, R. Valve, L. Karjalainen, L. Mykkanen, J. Kuusisto, S. Deeb, J. Auwerx, and M. Laakso. 2000. The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia. Atherosclerosis. 151: 567-574.
9. Swarbrick, M. M., C. M. Chapman, B. M. McQuillan, J. Hung, P. L. Thompson, and J. P. Beilby. 2001. A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity. Eur. J. Endocrinol. 144: 277-282.
10. Ellison, R. C., Y. Zhang, M. M. Qureshi, S. Knox, D. K. Arnett, and M. A. Province for the Investigators of the NHLBI Family Heart Study. 2004. Lifestyle determinants of high-density lipoprotein cholesterol. The National Heart, Lung, and Blood Institute Family Heart Study. Am. Heart J. 147: 529-535.
11. 41st World Medical Assembly. 1990. Declaration of Helsinki: recommendations guiding physicians in biomedical research involving human subjects. Bull. Pan. Am. Health Organ. 24: 606-609.
12. Staessen, J. A., R. Fagard, and A. Amery. 1994. Life style as a determinant of blood pressure in the general population. Am. J. Hypertens. 7: 685-694.
13. Marcadet, A., P. O'Connell, and D. Cohen. 1986. Standardized Southern blot workshop technique. In Histocompatibility Testing. B. Dupont, editor. Springer, New York. 553-560.
14. Herrmann, S. M., J. Ringel, J. G. Wang, J. A. Staessen, and E. Brand. 2002. Peroxisome proliferator-activated receptor γ2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes mellitus. The Berlin Diabetes Mellitus (BeDiaM) Study. Diabetes. 51: 2653-2657.
15. Zeger, S. L., K. Y. Liang, and P. S. Albert. 1988. Models for longitudinal data: a generalized estimating equation approach. Biometrics. 44: 1049-1060.
16. The SAS Institute, Inc. 2000. The GENMOD procedure. In SAS Online Doc Version 7.1. SAS/STAT, Cary, NC. 1311-1411.
17. Abecasis, G. R., L. R. Cardon, and W. O. C. Cookson. 2000. A general test of association for quantitative traits in nuclear families. Am. J. Hum. Genet. 66: 279-292.
18. Chinetti, G., S. Lestavel, V. Bocher, A. T. Remaley, B. Neve, I. P. Torra, E. Teissier, A. Minnich, M. Jaye, N. Duverger, et al. 2001. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 7: 53-58.
19. Costet, P., Y. Luo, N. Wang, and A. R. Tall. 2000. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 275: 28240-28245.
20. Rotondo, S., A. Di Castelnuovo, and G. de Gaetano. 2001. The relationship between wine consumption and cardiovascular risk: from epidemiological evidence to biological plausibility. Ital. Heart J. 2: 1-8.
21. Rimm, E. B., P. Williams, K. Fosher, M. Criqui, and M. J. Stampfer. 1999. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ. 319: 1523-1528.
22. Memisoglu, A., F. B. Hu, S. E. Hankinson, J. E. Manson, I. De Vivo, W. C. Willett, and D. J. Hunter. 2003. Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Hum. Mol. Genet. 12: 2923-2929.
23. Galli, A., J. Pinaire, M. Fischer, R. Dorris, and D. W. Crabb. 2001. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J. Biol. Chem. 276: 68-75.
24. Wezeman, F. H., and Z. Gong. 2004. Adipogenic effect of alcohol on human bone marrow-derived mesenchymal stem cells. Alcohol. Clin. Exp. Res. 28: 1091-1101.
25. Kojo, H., K. Tajima, M. Fukagawa, T. Isogai, and S. Nishimura. 2004. Molecular cloning and characterization of two novel human RXR alpha splice variants. J. Steroid Biochem. Mol. Biol. 92: 19-28.
26. Fumeron, F., D. Betoulle, G. Luc, I. Behague, S. Ricard, O. Poirier, R. Jemaa, A. Evans, D. Arveiler, P. Marques-Vidal, et al. 1995. Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction. J. Clin. Invest. 96: 1664-1671.