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Volumn 64, Issue 4, 2003, Pages 366-370

The effects of the Pro12Ala polymorphism of the PPARγ-2 gene on lipid metabolism interact with body size at birth

Author keywords

Birth weight; Developmental plasticity; Dyslipidemia; Gene environment interaction; PPAR 2 gene

Indexed keywords

ALANINE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE;

EID: 0141886852     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2003.00150.x     Document Type: Article
Times cited : (44)

References (32)
  • 1
    • 0024871673 scopus 로고
    • Phenotypic plasticity and the origins of diversity
    • West-Eberhard MJ. Phenotypic plasticity and the origins of diversity. Annu Rev Ecol Syst 1989: 20: 249-278.
    • (1989) Annu. Rev. Ecol. Syst. , vol.20 , pp. 249-278
    • West-Eberhard, M.J.1
  • 3
    • 0026008824 scopus 로고
    • Fetal and infant growth and impaired glucose tolerance at age 64
    • Hales CN, Barker DJP, Clark PMS et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991: 303: 1019-1022.
    • (1991) BMJ , vol.303 , pp. 1019-1022
    • Hales, C.N.1    Barker, D.J.P.2    Clark, P.M.S.3
  • 5
    • 0033550681 scopus 로고    scopus 로고
    • Catch-up growth in childhood and death from coronary heart disease: Longitudinal study
    • Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJP. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ 1999: 318: 427-431.
    • (1999) BMJ , vol.318 , pp. 427-431
    • Eriksson, J.G.1    Forsen, T.2    Tuomilehto, J.3    Winter, P.D.4    Osmond, C.5    Barker, D.J.P.6
  • 6
    • 0028883836 scopus 로고
    • The fetal origins of adult disease
    • Barker DJP. The fetal origins of adult disease. Proc R Soc Lond B 1995: 262: 37-43.
    • (1995) Proc. R. Soc. Lond. B , vol.262 , pp. 37-43
    • Barker, D.J.P.1
  • 7
    • 0036303247 scopus 로고    scopus 로고
    • The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ 2 gene on insulin sensitivity and insulin metabolism interact with size at birth
    • Eriksson JG, Lindi V, Uusitupa M et al. The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ 2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes 2002: 51: 2321-2324.
    • (2002) Diabetes , vol.51 , pp. 2321-2324
    • Eriksson, J.G.1    Lindi, V.2    Uusitupa, M.3
  • 8
    • 0035094340 scopus 로고    scopus 로고
    • The pleiotropic functions of peroxisome proliferator-activated receptor-γ
    • Debril M-B, Renaud J-P, Fajas L, Auwerx J. The pleiotropic functions of peroxisome proliferator-activated receptor-γ. J Mol Med 2001: 79: 30-47.
    • (2001) J. Mol. Med. , vol.79 , pp. 30-47
    • Debril, M.-B.1    Renaud, J.-P.2    Fajas, L.3    Auwerx, J.4
  • 9
    • 0032588487 scopus 로고    scopus 로고
    • PPARγ, the ultimate thrifty gene
    • Auwerx J. PPARγ, the ultimate thrifty gene. Diabetologia 1999: 42: 1033-1049.
    • (1999) Diabetologia , vol.42 , pp. 1033-1049
    • Auwerx, J.1
  • 10
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M et al. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998: 20: 284-287.
    • (1998) Nat. Genet. , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 11
    • 0033304551 scopus 로고    scopus 로고
    • Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women
    • Valve R, Sivenius K, Miettinen R et al. Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women. J Clin Endocrinol Metab 1999: 84: 3708-3712.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3708-3712
    • Valve, R.1    Sivenius, K.2    Miettinen, R.3
  • 12
    • 0001491179 scopus 로고    scopus 로고
    • Impact of the peroxisome proliferator activated receptor γ 2 Pro12Ala polymorphism on adiposity, lipids, and non-insulin-dependent diabetes mellitus
    • Meirhaeghe A, Fajas L, Helbecque N et al. Impact of the peroxisome proliferator activated receptor γ 2 Pro12Ala polymorphism on adiposity, lipids, and non-insulin-dependent diabetes mellitus. Int J Obes 2000: 24: 195-199.
    • (2000) Int. J. Obes. , vol.24 , pp. 195-199
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3
  • 13
    • 0035929259 scopus 로고    scopus 로고
    • Identification of a novel peroxisome proliferator-activated receptor (PPAR)-γ promoter in man and transactivation by the nuclear receptor RORα1
    • Sunvold H, Lien S. Identification of a novel peroxisome proliferator-activated receptor (PPAR)-γ promoter in man and transactivation by the nuclear receptor RORα1. Biochem Biophys Res Commun 2001: 287: 383-390.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 383-390
    • Sunvold, H.1    Lien, S.2
  • 14
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation
    • Yen C-J, Beamer BA, Negri C et al. Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun 1997: 241: 270-274.
    • (1997) Biochem. Biophys. Res. Commun. , vol.241 , pp. 270-274
    • Yen, C.-J.1    Beamer, B.A.2    Negri, C.3
  • 15
    • 0031914386 scopus 로고    scopus 로고
    • Human peroxisome proliferator-activated receptor-γ2. Genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes
    • Vigouroux C, Fajas L, Khallouf E et al. Human peroxisome proliferator-activated receptor-γ2. Genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes. Diabetes 1998: 47: 490-492.
    • (1998) Diabetes , vol.47 , pp. 490-492
    • Vigouroux, C.1    Fajas, L.2    Khallouf, E.3
  • 16
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000: 26: 76-80.
    • (2000) Nat. Genet. , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 18
    • 0035002488 scopus 로고    scopus 로고
    • Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPARγ) gene and type 2 diabetes
    • Evans D, de Heer J, Hagemann C et al. Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPARγ) gene and type 2 diabetes. Exp Clin Endocrinol Diabetes 2001: 109: 151-154.
    • (2001) Exp. Clin. Endocrinol. Diabetes , vol.109 , pp. 151-154
    • Evans, D.1    de Heer, J.2    Hagemann, C.3
  • 19
    • 0034728762 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes
    • Hara K, Okada T, Tobe K et al. The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun 2000: 271: 212-216.
    • (2000) Biochem. Biophys. Res. Commun. , vol.271 , pp. 212-216
    • Hara, K.1    Okada, T.2    Tobe, K.3
  • 20
    • 17944362462 scopus 로고    scopus 로고
    • Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene in relation to insulin sensitivity among glucose tolerant Caucasians
    • Ek J, Andersen G, Urhammer SA et al. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene in relation to insulin sensitivity among glucose tolerant Caucasians. Diabetologia 2001: 44: 1170-1176.
    • (2001) Diabetologia , vol.44 , pp. 1170-1176
    • Ek, J.1    Andersen, G.2    Urhammer, S.A.3
  • 21
    • 0035914298 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity
    • Akiyama TE, Nicol CJ, Fievet C et al. Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity. J Biol Chem 2001: 276: 39088-39093.
    • (2001) J. Biol. Chem. , vol.276 , pp. 39088-39093
    • Akiyama, T.E.1    Nicol, C.J.2    Fievet, C.3
  • 22
    • 0036210553 scopus 로고    scopus 로고
    • The effects of childhood growth and maternal body size on insulin resistance in elderly men and women
    • Eriksson JG, Forsen T, Jaddoe VWV, Osmond C, Barker DJP. The effects of childhood growth and maternal body size on insulin resistance in elderly men and women. Diabetologia 2002: 45: 342-348.
    • (2002) Diabetologia , vol.45 , pp. 342-348
    • Eriksson, J.G.1    Forsen, T.2    Jaddoe, V.W.V.3    Osmond, C.4    Barker, D.J.P.5
  • 23
    • 0015348189 scopus 로고
    • Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge
    • Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972: 18: 499-502.
    • (1972) Clin. Chem. , vol.18 , pp. 499-502
    • Friedwald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 24
    • 0034771048 scopus 로고    scopus 로고
    • Mutations of the peroxisome proliferator-activated receptor γ (PPARγ) gene in a Japanese population: The Pro12Ala mutation in the PPARγ2 is associated with lower concentrations of serum total and non-HDL cholesterol
    • Iwata E, Matsuda H, Fukuda T et al. Mutations of the peroxisome proliferator-activated receptor γ (PPARγ) gene in a Japanese population: the Pro12Ala mutation in the PPARγ2 is associated with lower concentrations of serum total and non-HDL cholesterol. Diabetologia 2001: 44: 1354-1356.
    • (2001) Diabetologia , vol.44 , pp. 1354-1356
    • Iwata, E.1    Matsuda, H.2    Fukuda, T.3
  • 25
    • 0033811933 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells
    • Dubois M, Pattou F, Kerr-Conte J et al. Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells. Diabetologia 2000: 43: 1165-1169.
    • (2000) Diabetologia , vol.43 , pp. 1165-1169
    • Dubois, M.1    Pattou, F.2    Kerr-Conte, J.3
  • 26
    • 0027240176 scopus 로고
    • Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
    • Abumrad NA, el-Maghrabi MR, Amri EZ, Lopez E, Grimaldi PA. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J Biol Chem 1993: 268: 17665-17668.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17665-17668
    • Abumrad, N.A.1    el-Maghrabi, M.R.2    Amri, E.Z.3    Lopez, E.4    Grimaldi, P.A.5
  • 27
    • 0036835826 scopus 로고    scopus 로고
    • PPARγ2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population
    • Yamamoto Y, Hirose H, Miyashita K et al. PPARγ2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population. Metabolism 2002: 51: 1407-1409.
    • (2002) Metabolism , vol.51 , pp. 1407-1409
    • Yamamoto, Y.1    Hirose, H.2    Miyashita, K.3
  • 28
    • 0036399092 scopus 로고    scopus 로고
    • Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR γ2 gene in healthy individuals
    • Vaccaro O, Mancini FP, Ruffa G et al. Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR)γ2 gene in healthy individuals. Clin Endocrinol 2002: 57: 481-486.
    • (2002) Clin. Endocrinol. , vol.57 , pp. 481-486
    • Vaccaro, O.1    Mancini, F.P.2    Ruffa, G.3
  • 29
    • 0035123646 scopus 로고    scopus 로고
    • Evidence for gene-nutrient interaction at the PPAR-γ locus
    • Luan J, Browne PO, Harding A-H et al. Evidence for gene-nutrient interaction at the PPAR-γ locus. Diabetes 2001: 50: 686-689.
    • (2001) Diabetes , vol.50 , pp. 686-689
    • Luan, J.1    Browne, P.O.2    Harding, A.-H.3
  • 30
    • 0036329369 scopus 로고    scopus 로고
    • Association of the Pro12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study
    • Lindi VI, Uusitupa MIJ, Lindström J et al. Association of the Pro12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 2002: 51: 2581-2586.
    • (2002) Diabetes , vol.51 , pp. 2581-2586
    • Lindi, V.I.1    Uusitupa, M.I.J.2    Lindström, J.3
  • 31
    • 0033304551 scopus 로고    scopus 로고
    • Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women
    • Valve R, Sivenius K, Miettinen R et al. Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women. J Clin Endocrinol Metab 1999: 84: 3708-3712.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3708-3712
    • Valve, R.1    Sivenius, K.2    Miettinen, R.3
  • 32
    • 0033662314 scopus 로고    scopus 로고
    • The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity
    • Le Stunff C, Fallin D, Schork NJ, Bougnères P. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Nat Genet 2000: 26: 444-446.
    • (2000) Nat. Genet. , vol.26 , pp. 444-446
    • Le Stunff, C.1    Fallin, D.2    Schork, N.J.3    Bougnères, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.