The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

Genes and Development

Volumn 10, Issue 7, 1996, Pages 816-825

  Nikolic, Margareta ^a   Dudek, Henryk ^a,b   Kwon, Young T ^a   Ramos, Yolande F M ^a   Tsai, Li Huei ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cdk5; dominant negative mutants; growth cone; neurite outgrowth; p35

Indexed keywords

CYCLIN DEPENDENT KINASE; HISTONE H1; PROTAMINE KINASE; PROTEIN P35; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; EMBRYO; ENZYME REGULATION; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GROWTH INHIBITION; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY;

EID: 0029966469     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.10.7.816     Document Type: Article

References (19)

1. Cepko, C.L., C.P. Austin, C. Walsh, E.F. Ryder, A. Halliday, and S. Fields-Berry. 1990. Studies of cortical development using retrovirus vectors. Cold Spring Harb. Symp. Quant. Biol 55: 265-278.
2. DeBondt, H.L., J. Rosenblatt, J. Jancarik, H.D. Jones, D.O. Morgan, and S.-H. Kim. 1993. Crystal structure of cyclin-dependent kinase 2 Nature 363: 595-602.
3. Graham, F.L. and A.J. Van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52: 456-467.
4. Halliday, A.L. and L.C. Cepko. 1992. Generation and migration of cells in the developing striatum. Neuron 9: 15-26.
5. Ishiguro, K., S. Kobayashi, A. Omore, M. Takamatsu, S. Yonekura, K. Anzai, K. Imahori, and T. Uchida. 1994. Identification of the 23kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain. FEBS Lett 342: 203-208.
6. Jeffrey, P.D., A.A. Russo, K. Polyak, E. Gibbs, J. Hurwitz, J. Massague, and N.P. Pavletich. 1995. Mechanism of cdk activation revealed by the structure of a cyclin A-cdk2 complex. Science 376: 313-320.
7. Kosik, K.S. and A. Caceres. 1991. Tau protein and the establishment of an axonal morphology. J. Cell Sci. (Suppl.) 15: 69-74.
8. Lew, J. and J.H. Wang. 1995. Neuronal cdc2-like kinase Trends Biochm. Sci. 20: 33-37.
9. Lew, J., K. Beaudette, C.M.E. Litwin, and J.H. Wang. 1992a. Purification and characterization of a novel proline-directed protein kinase from bovine brain. J. Biol. Chem. 267: 13383-13390.
10. Lew, J., R.J. Winkfein, H.K. Paudel, and J.H. Wang. 1992b. Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. J. Biol. Chem. 267: 25922-25926.
11. Lew, J., Q.-Q. Huang, R.J. Winkfein, Z. Qi, R. Aebersold, T. Hunt, and J.H. Wang. 1994. Neuronal cdc2-like kinase is a complex of cyclin-dependent kinase 5 and a novel brain-specific regulatory subunit. Nature 371: 423-425.
12. Meyerson, M., G.H. Enders, C.-L. Wu, L.-K. Su, C. Gorka, C. Nelson, E. Harlow, and L.-H. Tsai. 1992. A family of human cdc2-related protein kinases. EMBO J. 11: 2909-2917.
13. Reid, C.B., I. Liang, and C. Walsh. 1995. Systematic widespread clonal organization in cerebral cortex. Neuron 15: 299-310.
14. Shetty, K.T., W.T. Link, and H.C. Pant. 1993. Cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXX motifs in neurofilament proteins: Isolation and characterization. Proc. Natl. Acad. Sci. 90: 6844-6848.
15. Taylor, S.S., D.R. Knighton, J. Zheng, J.M. Sowadski, C.S. Gibbs, and M.J. Zoller. 1993. A template for the protein kinase family. Trends Biochem. Sci. 18: 84-89.
16. Tsai, L.-H., T. Takahashi, V.S. Caviness Jr., and E. Harlow. 1993. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development 119: 1029-1040.
17. Tsai, L.-H., I. Delalle, V.S. Caviness Jr., T. Chae, and E. Harlow. 1994. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371: 419-423.
18. van den Heuvel, S. and E. Harlow. 1994. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262: 2050-2054.
19. Wang, N., J.P. Butler, and D.E. Ingber. 1993. Mechanotransduction across the cell surface and through the cytoskeleton. Science 260: 1124-1127