Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia

Journal of Applied Physiology

Volumn 93, Issue 3, 2002, Pages 1131-1139

  Pichiule, Paola ^a   Lamanna, Joseph C ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Angiopoietins; Brain capillary density; Vascular regression

Indexed keywords

ANGIOPOIETIN 2; CASPASE 3; AGPT PROTEIN, RAT; ANGIOGENIC FACTOR; ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; MEMBRANE PROTEIN; MEN1 PROTEIN, HUMAN; ONCOPROTEIN; TUMOR PROTEIN;

ADAPTATION; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CAPILLARY; BRAIN DEVELOPMENT; CAPILLARY DENSITY; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; HYPOXIA; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; ANOXIA; BRAIN CIRCULATION; CAPILLARY; CHRONIC DISEASE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TIME; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIUM; WISTAR RAT;

ADAPTATION, PHYSIOLOGICAL; ANGIOGENESIS INDUCING AGENTS; ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; ANOXIA; APOPTOSIS; CAPILLARIES; CEREBROVASCULAR CIRCULATION; CHRONIC DISEASE; ENDOTHELIUM, VASCULAR; MALE; MEMBRANE GLYCOPROTEINS; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS; RATS; RATS, WISTAR; RECEPTOR, TIE-2; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0036707853     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00318.2002     Document Type: Article

References (38)

1. Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats
2. Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat
3. Specific caspase pathways are activated in the two stages of cerebral infarction
4. Increased brain capillaries in chronic hypoxia
5. Angiogenesis in cancer and other diseases
6. Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia
7. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period
8. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
9. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
10. Noninvasive assessment of cerebral oxygenation during acclimation to hypobaric hypoxia
11. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
12. Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells
13. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
14. Time-course and reversibility of the hypoxia-induced alterations in cerebral vascularity and cerebral capillary glucose transporter density
15. Endothelial proliferation in tumours and normal tissues: Continuous labelling studies
16. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
17. Tie receptors: New modulators of angiogenic and lymphangiogenic responses
18. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
19. Role of angiogenesis in patients with cerebral ischemic stroke
20. Brain metabolic and vascular adaptations to hypoxia in the rat. Review and update
21. Brain adaptation to chronic hypobaric hypoxia in rats
22. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion
23. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
24. Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia
25. Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors
26. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
27. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
28. Direct actions of angiopoietin-1 on human endothelium: Evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors
29. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
30. Blood-brain barrier glucose transporter: Effects of hypo- and hyperglycemia revisited
31. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
32. Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2
33. Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin- 2
34. Collateral growth and angiogenesis around cortical stroke
35. Tie 2 expression and phosphorylation in angiogenic and quiescent adult tissues
36. Caspase-dependent apoptotic pathways in CNS injury
37. Vascular apoptosis and involution in gliomas precede neovascularization: A novel concept for glioma growth and angiogenesis
38. Correlation of VEGF and angiopoietin expression with disruption of blood brain barrier and angiogenesis after focal cerebral ischemia