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34249947467
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14
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34249929738
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Acetylcholinesterase inhibitor: (a) Goto, G.; Ishihara, Y.; Miyamoto, M. Condensed heterocyclic compounds, their production and use. EP 487071, 1992.
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34249942214
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CETP inhibitors: Guoqing, C, Escribano, A. M, Fernandez, M. C, Fields, T, Gernert, D. L, Cioffi, C. L, Herr, R. J, Mantlo, N. B, Martin de la Nava, E. M, Mateo Herranz, A. I, Mayhugh, D. R, Wang, X. Compounds and methods for treating dyslipidemia. WO 2005037796, 2005
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CETP inhibitors: Guoqing, C.; Escribano, A. M.; Fernandez, M. C.; Fields, T.; Gernert, D. L.; Cioffi, C. L.; Herr, R. J.; Mantlo, N. B.; Martin de la Nava, E. M.; Mateo Herranz, A. I.; Mayhugh, D. R.; Wang, X. Compounds and methods for treating dyslipidemia. WO 2005037796, 2005.
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34249929980
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34249935956
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19
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34249937779
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RXR agonist: Hibi, S, Kikuchi, K, Yoshimura, H, Nagai, M, Tagami, K, Abe, S, Hishinula, I, Nagakawa, J, Miyamoto, N, Hida, T, Ogasawara, A, Higashi, S, Tai, K, Yamanaka, T, Asasa, M. Mono- or polyenic carboxylic acid derivatives. US 6,420,363, 2002
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RXR agonist: Hibi, S.; Kikuchi, K.; Yoshimura, H.; Nagai, M.; Tagami, K.; Abe, S.; Hishinula, I.; Nagakawa, J.; Miyamoto, N.; Hida, T.; Ogasawara, A.; Higashi, S.; Tai, K.; Yamanaka, T.; Asasa, M. Mono- or polyenic carboxylic acid derivatives. US 6,420,363, 2002.
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20
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34249951805
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MBR antagonist: Takuya, S.; Seishi, K.; Masashi, K.; Junichiro, M.; Ohmoto, K. N-carbanoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient. WO 03068753, 2003.
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34249938807
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Inhibitor N-type calcium channels: Takuya, E.; Kazuya, H. Benzazepine derivative. JP 2002363163, 2002.
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22
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34249935467
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30344449174
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31
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3843146342
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Oxytocin agonist: Pitt, G. R. W.; Batt, A. R.; Haigh, R. M.; Penson, A. M.; Robson, P. A.; Rooker, D. P.; Tartar, A. L.; Trim, J. E.; Yeaa, C. M.; Roea, M. B. Bioorg. Med. Chem. Lett. 2004, 14, 4585-4589.
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32
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34249950230
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GHS agonist: Li, J. J. Benzoazepines and analogs thereof useful as growth hormone secretagogues. WO 0024398, 2000.
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33
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34249940380
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LHRH antagonist: Kazumasa, H.; Tsuneo, O.; Masami, K.; Naoyuki, K. Fused pyrimidine derivative and use thereof. WO 2005019188, 2005.
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34
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10444259767
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CCR5 antagonist: Seto, M.; Miyamoto, N;. Aikawa, K.; Aramaki, Y.; Kanzaki, N.; lizawa, Y.; Baba, M.; Shiraishi, M. Biorg. Med. Chem. 2005, 13, 363-383.
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40
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34249939649
-
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Microwave irradiation (120°C, 15 min) could be alternatively used to remove the Ts group with a similar result.
-
Microwave irradiation (120°C, 15 min) could be alternatively used to remove the Ts group with a similar result.
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41
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34249938126
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Three alternative protecting groups orthogonal to acid-labile linkers were evaluated but found either not compatible with our synthetic scheme (Fmoc) or not convenient/amenable for preparation of a large library Alloc, oNS
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Three alternative protecting groups orthogonal to acid-labile linkers were evaluated but found either not compatible with our synthetic scheme (Fmoc) or not convenient/amenable for preparation of a large library (Alloc, oNS).
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