Characterization of orally active nonpeptide vasopressin V2 receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-chloro-4-pyrrolidin-1-yl-benzoyl)- 2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]-N-isopropylacetamide

Journal of Medicinal Chemistry

Volumn 45, Issue 17, 2002, Pages 3805-3808

  Kondo, Kazumi ^a   Kan, Keizo ^a   Tanada, Yoshihisa ^a   Bando, Masahiko ^a   Shinohara, Tomoichi ^a   Kurimura, Muneaki ^a   Ogawa, Hidenori ^a   Nakamura, Shigeki ^a   Hirano, Takahiro ^a   Yamamura, Yoshitaka ^a   Kido, Masaru ^a   Mori, Toyoki ^a   Tominaga, Michiaki ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (2 CHLORO 4 PYRROLIDIN 1 YLBENZOYL) 2,3,4,5 TETRAHYDRO 1H 1 BENZAZEPIN 5 YL] N ISOPROPYLACETAMIDE; BENZAZEPINE DERIVATIVE; CYCLIC AMP; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; VASOPRESSIN V2 RECEPTOR;

ANIMAL EXPERIMENT; ANTIDIURESIS; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOMER; NONHUMAN; RAT; RAT STRAIN; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; HELA CELLS; HUMANS; RADIOLIGAND ASSAY; RATS; RATS, BRATTLEBORO; RECEPTORS, VASOPRESSIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037103346     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020133q     Document Type: Article

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