Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors

Journal of Biological Chemistry

Volumn 278, Issue 41, 2003, Pages 40010-40019

  Tahtaoui, Chouaïb ^a   Balestre, Marie Noëlle ^b   Klotz, Philippe ^a   Rognan, Didier ^a   Barberis, Claude ^b   Mouillac, Bernard ^b   Hibert, Marcel ^a  

^a CNRS   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL SENSORS; MUTAGENESIS;

PHARMACOLOGICAL PROPERTIES;

BIOCHEMISTRY;

ALPHA CHLOROACETAMIDE; CHLOROACETAMIDE; CYSTEINE; ISOTHIOCYANIC ACID; OXYTOCIN; OXYTOCIN RECEPTOR; PHENYLALANINE; RELCOVAPTAN; THIOL GROUP; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN V1 RECEPTOR; VASOPRESSIN V1A RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN COS7; CHEMICAL MODIFICATION; CHEMICAL SENSOR; CHO CELL; CONTROLLED STUDY; COVALENT BOND; DOSE RESPONSE; LIGAND BINDING; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SENSOR;

AMINO ACID SEQUENCE; BINDING SITES; CYSTEINE; HORMONE ANTAGONISTS; HUMANS; INDOLES; KINETICS; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PYRROLIDINES; RECEPTORS, VASOPRESSIN; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SULFHYDRYL COMPOUNDS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0141925616     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301128200     Document Type: Article

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