Solid-supported solution-phase synthesis of 4-amino-1,2,4,5-tetrahydro-2- benzazepine-3-ones

Journal of Combinatorial Chemistry

Volumn 6, Issue 4, 2004, Pages 468-473

  Van Den Eynde, Isabelle ^a   Van Rompaey, Karolien ^a   Lazzaro, Francesco ^a,b   Tourwé, Dirk ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; ALDEHYDE DERIVATIVE; BENZALDEHYDE DERIVATIVE; BENZAZEPINE DERIVATIVE; BORON DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; ISOCYANIC ACID DERIVATIVE; NITROGEN; PHENYLALANINE DERIVATIVE; POLYMER; SULFONE DERIVATIVE;

ACYLATION; AMINATION; ARTICLE; COMBINATORIAL CHEMISTRY; CROSS COUPLING REACTION; CYCLIZATION; DEPROTECTION REACTION; LIQUID LIQUID EXTRACTION; ORGANIC CHEMISTRY; PHASE TRANSITION; POLYMERIZATION; PURIFICATION; QUANTUM YIELD; REACTION ANALYSIS; REDUCTION; SOLID STATE; SUBSTITUTION REACTION; SYNTHESIS;

ALDEHYDES; AMIDES; AMINATION; BENZAZEPINES; HYDROXYLATION; MOLECULAR STRUCTURE; SOLUTIONS; SULFUR;

EID: 4143076840     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc049940w     Document Type: Article

References (18)

1. Bräse, S.; Gil, C.; Knepper, K. Bioorg. Med. Chem. 2002, 10, 2415-2437.
2. Franzén, R. G. J. Comb. Chem. 2000, 2 (3), 205-207.
3. Dolle, R. E. J. Comb. Chem. 2001, 3 (6), 477-517.
4. Dolle, R. E. J. Comb. Chem. 2002, 4 (5), 369-418.
5. Tourwé, D.; Frycia, A.; Davis, P.; Hruby, V. J.; Toth, G.; Jaspers, H.; Verheyden, P.; Van Binst, G. Biopolymers 1995, 38, 1-12.
6. Flynn, G. A.; Burkholder, T. P.; Huber, E. W.; Bey, P. Bioorg. Med. Chem. Lett. 1991, 1, 309-312.
7. Warshawsky, A. M.; Flynn, G. A.; Koehl, J. R.; Mehdi, S.; Vaz, R. J. Bioorg. Med. Chem. Lett. 1996, 6, 957-962.
8. Miller, W. H.; Alberts, D. P.; Bhatnagar, P. K.; Bondinell, W. E.; Callahan, P. K.; Calvo, R. R.; Cousins, R. D.; Erhard, K. F.; Huffman, W. F. J. Med. Chem. 2000, 43, 22-26.
9. Sidduri, A.; Lou, J. P.; Campbell, R.; Rowan, K.; Tilley, J. W. Tetrahedron Lett. 2001, 42, 8757-8760.
10. Gamez-Montano, R.; Chavez, M. I.; Roussi, G.; Cruz-Almanza, R. Tetrahedron Lett. 2001, 42, 9-12.
11. Ollero, L.; Castedo, L.; Domínguez, D. Tetrahedron 1999, 55, 4445-4456.
12. Scott, L. J.; Goa, K. L. Drugs 2000, 60, 1095-1122.
13. Van Rompaey, K.; Van den Eynde, I.; De Kimpe, N.; Tourwé, D. Tetrahedron 2003, 59 (24), 4421-4432.
14. Kirschning, A.; Monenstein, H.; Wittenberg, R. Angew. Chem., Int. Ed. 2001, 40, 650-679.
15. Ley, S. V.; Baxendale, I. R.; Bream, R. N.; Jackson, P. S.; Leach, A. G.; Longbottom, D. A.; Nesi, M.; Scott, J. S.; Storer, R. I.; Taylor, S. J. J. Chem. Soc., Perkin Trans. 1 2000, 3815-4195.
16. Resins and Reagents Catalog, Technical Handbook; Argonaut: Foster City, CA; 2002, pp 20-21.
17. Labadie, J. W.; Rana, S.; Lindberg, T.; Gooding, O.; Bhattacharyya, S. In Abstracts of Papers; 222nd ACS National Meeting, Chicago, IL, August 26-30-2001.
18. Synthesis and Purification Catalog, Argonaut: Foster City, CA, 2003; pp 66-70.