A model of restriction endonuclease MvaI in complex with DNA: A template for interpretation of experimental data and a guide for specificity engineering

Proteins: Structure, Function and Genetics

Volumn 68, Issue 1, 2007, Pages 324-336

  Kosinski, Jan ^a   Kubareva, Elena ^b   Bujnicki, Janusz M ^a  

^a INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Extreme divergence; Fold recognition; GeneSilico; Homology modeling; Model validation; Molecular evolution; Restriction endonuclease MvaI; Sequence alignment; Structure prediction

Indexed keywords

AMINO ACID; DNA; NUCLEOTIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN MUTH; RESTRICTION ENDONUCLEASE; RESTRICTION ENDONUCLEASE MVAI; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DNA PROTEIN COMPLEX; DNA SEQUENCE; DNA STRAND BREAKAGE; ENZYME ENGINEERING; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; EVOLUTION; HYDROLYSIS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; COMPUTATIONAL BIOLOGY; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR ENZYMES; EVOLUTION, MOLECULAR; LIKELIHOOD FUNCTIONS; MODELS, GENETIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN ENGINEERING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SUBSTRATE SPECIFICITY;

EID: 34249866596     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21460     Document Type: Article

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