N9-Benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: Synthesis and structure-activity relationships at adenosine A1 and A2A receptors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 14, 2007, Pages 5003-5017

  Drabczyńska, Anna ^a   Müller, Christa E ^b   Karolak Wojciechowska, Janina ^c   Schumacher, Britta ^b   Schiedel, Anke ^b   Yuzlenko, Olga ^a   Kieć Kononowicz, Katarzyna ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b UNIVERSITY OF BONN   (Germany)

^c LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

A2A receptor antagonists; Adenosine A1; Pyrimido 2,1 f purinediones; Tricyclic xanthine derivatives

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; CAFFEINE; ISTRADEFYLLINE; KETONE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; CYCLIZATION; DRUG SELECTIVITY; DRUG SYNTHESIS; MICROWAVE RADIATION; NONHUMAN; PHARMACODYNAMICS; PHARMACOPHORE; PHYSICAL CHEMISTRY; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZENE; CHEMISTRY, PHYSICAL; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; METHYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROPANE; PURINES; PYRIMIDINES; RATS; RECEPTOR, ADENOSINE A1; RECEPTORS, ADENOSINE A2; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 34249731979     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.04.018     Document Type: Article

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