1,8-Disubstituted xanthine derivatives: Synthesis of potent A2B-selective adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2002, Pages 1500-1510

  Hayallah, Alaa M ^a,d   Sandoval Ramírez, Jesús ^b,e   Reith, Ulrike ^a   Schobert, Ulrike ^b   Preiss, Birgit ^a   Schumacher, Britta ^a   Daly, John W ^c   Müller, Christa E ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Assiut University   (Egypt)

^e BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTYL 8 (4 CARBOXYPHENYLXANTHINE); 1 BUTYL 8 [4 (4 BENZYL)PIPERAZINO 2 OXOETHOXYPHENYL]XANTHINE; 1 PROPYL 8 (4 SULFOPHENYLXANTHINE); 8 [4 (2 HYDROXYETHYLAMINO) 2 OXOETHOXYPHENYL] 1 PROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; CARBOXYLIC ACID; CYCLOPENTANE; PHENYL GROUP; RECEPTOR SUBTYPE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; NONHUMAN; POLARIZATION; PROTEIN FUNCTION; RAT;

AMINES; ANIMALS; BENZOIC ACID; CELL LINE; CHO CELLS; CRICETINAE; FIBROBLASTS; HUMANS; KINETICS; MODELS, CHEMICAL; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; XANTHINES;

EID: 0037187362     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011049y     Document Type: Article

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