SCOPUS 정보 검색 플랫폼

Volumn 45, Issue 16, 2002, Pages 3440-3450

Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: Potent A2A- and A3-adenosine receptor antagonistst

(7) Müller, Christa E a Thorand, Mark a Qurishi, Ramatullah a Diekmann, Martina a Jacobson, Kenneth A b Padgett, William L b Daly, John W b

a UNIVERSITY OF BONN (Germany)

b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIMETHYL 8 ETHYL 2 STYRYLIMIDAZO[2,1 I]PURINONE; 4 METHYL 8 ETHYL 2 PHENYLIMIDAZO[2,1 I]PURIN 5 ONE; 8 STYRYLXANTHINE DERIVATIVE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; ADENYLATE CYCLASE; BETA CYCLODEXTRIN DERIVATIVE; PURINE DERIVATIVE; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN; CAPILLARY ELECTROPHORESIS; CHIRALITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENANTIOMER; MOUSE; NONHUMAN; PROTON TRANSPORT; RADIOASSAY; RAT; RECEPTOR AFFINITY; SOLUBILITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

3T3 CELLS; ADENYLATE CYCLASE; ANIMALS; BRAIN; ELECTROPHORESIS, CAPILLARY; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; IMIDAZOLES; MEMBRANES; MICE; PC12 CELLS; PURINES; PURINONES; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 0036682414 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm011093d Document Type: Article

Times cited : (90)

References (41)

2
- 0033756241
- Structure and function of adenosine receptors and their genes
- (2000) Naunyn-Schmiedberg's Arch. Pharmacol. , vol.362 , pp. 364-374
- Fredholm, B.B.¹ Arslan, G.² Halldner, L.³ Kull, B.⁴ Schulte, G.⁵ Wasserman, W.⁶

3
- 0031833150
- Adenosine receptors: New opportunities for future drugs
- (1998) Bioorg. Med. Chem. , vol.6 , pp. 619-641
- Poulsen, S.A.¹ Quinn, R.J.²

4
- 2842546966
- Adenosine receptor antagonists: Structures and potential therapeutic applications
- (1996) Curr. Pharm. Des. , vol.2 , pp. 501-530
- Müller, C.E.¹ Stein, B.²

5
- 0031007914
- 1-Adenosine receptor antagonists
- (1997) Exp. Opin. Ther. Pat. , vol.7 , pp. 419-440
- Müller, C.E.¹

6
- 0033639016
- 2A Adenosine receptor antagonists - Future drugs for Parkinson's disease?
- (2000) Drugs Future , vol.25 , pp. 1043-1052
- Müller, C.E.¹

7
- 0035523827
- 3 Adenosine receptor antagonists
- (2001) Mini-Rev. Med. Chem. , vol.1 , pp. 433-443
- Müller, C.E.¹

8
- 0031283107
- 2B receptors
- (1997) Pharmacol. Rev. , vol.49 , pp. 381-402
- Feoktistov, I.¹ Biaggioni, I.²

9
- 0034052190
- 3 adenosine receptor ligands: History and perspectives
- (2000) Med. Res. Rev. , vol.20 , pp. 103-128
- Baraldi, P.G.¹ Cacciari, B.² Romagnoli, R.³ Merighi, S.⁴ Varani, K.⁵ Borea, P.A.⁶ Spalluto, G.⁷

10
- 0033756079
- Adenosine receptors and their ligands
- (2000) NaunynSchmiedberg's Arch. Pharmacol. , vol.362 , pp. 382-391
- Klotz, K.-N.¹

11
- 0026783826
- 1 antagonist
- (1992) J. Med. Chem. , vol.35 , pp. 3578-3581
- Suzuki, F.¹ Shimada, J.² Nonaka, H.³ Ishii, A.⁴ Shiozaki, S.⁵ Ichikawa, S.⁶ Ono, E.⁷

12
- 33947452031
- Synthesis of 1-mono- and 1,3- disubstituted 6-aminouracils. Diuretic activity
- (1951) J. Org. Chem. , vol.16 , pp. 1879-1891
- Papesch, V.¹ Schroeder, E.F.²

13
- 0000396592
- Pyrimidopteridines by oxidative self-condensation of aminopyrimidines
- (1955) J. Am. Chem. Soc. , vol.77 , pp. 2243-2248
- Tylor E.C., Jr.¹ Loux, H.M.² Falco, E.A.³ Hitchings, G.H.⁴

14
- 0017355354
- Oxidatve cyclization of 6-amino-5-benzylidene-amino-1,3-dimethyluracils with thionyl chloride. A convenient synthesis of 8-substituted theophyllines
- (1977) Chem. Pharm. Bull. , vol.25 , pp. 495-497
- Senga, K.¹ Shimizu, K.² Nishigaki, S.³

15
- 0009845982
- 5-Halo-6-aminouracils and derivatives. US 1956, 2, 731, 45, 465
- Schroeder, E.F.¹

16
- 84936365224
- Vereinfachte synthesen für 7-methyl- und 1,7-dimethylxanthin und -harnsäure
- (1979) Liebigs Ann. Chem. , pp. 1847-1854
- Hutzenlaub, W.¹ Pfleiderer, W.²

17
- 0001461940
- 3,7-Dialkyl-8-alkyl-or -aryl-3,7-dihydropurine-2,6-diones
- (1990) Collect. Czech. Chem. Commun. , vol.55 , pp. 2257-2269
- Rybár, A.¹ Hesek, D.² Szemes, F.³ Alfoldi, J.⁴

18
- 0027481318
- A convenient synthesis of tricyclic purine derivatives
- (1993) J. Heterocycl. Chem. , vol.30 , pp. 241-246
- Shimada, J.¹ Kuroda, T.² Suzuki, F.³

19
- 0026641583
- 2 receptors
- (1992) J. Med. Chem. , vol.35 , pp. 3263-3269
- Peet, N.P.¹ Lentz, N.L.² Sunder, S.³ Dudley, M.W.⁴ Ogden, A.M.L.⁵

20
- 0009851864
- Nucleosidsynthesen. XVIII. Aminierung von heterocyclen. I. Eine neue einfache synthese von cytidinen
- (1975) Liebigs Ann. Chem. , pp. 745-761
- Vorbrüggen, H.¹ Krolkiewiecz, K.²

21
- 0343394984
- Current methods for determination of enantiomeric compositions (part 2): NMR spectroscopy with chiral lanthanide shift reagents
- (1985) Kontakte , pp. 22-36
- Schurig, V.¹

22
- 0000237404
- NMR determination of enantiomeric purity
- (1991) Chem. Rev. , vol.91 , pp. 1441-1457
- Parker, D.¹

23
- 0027938071
- Sulfobutyl ether β-cyclodextrin as chiral discriminator for use with capillary electrophoresis
- (1994) Anal. Chem. , vol.66 , pp. 4013-4018
- Tait, R.J.¹ Thompson, D.O.² Stella, V.J.³ Stobaugh, J.F.⁴

24
- 0033662133
- Enantioseparation of dihydropyridine derivatives by means of neutral and negatively charged β-cyclodextrin derivatives using capillary electrophoresis
- (2000) Electrophoresis , vol.21 , pp. 3609-3617
- Christians, T.¹ Holzgrabe, U.²

25
- 0031463493
- 2A-selective adenosine receptor antagonists
- (1997) J. Med. Chem. , vol.40 , pp. 4396-4405
- Müller, C.E.¹ Geis, U.² Hipp, J.³ Schobert, U.⁴ Frobenius, W.⁵ Pawlowski, M.⁶ Suzuki, F.⁷ Sandoval-Ramírez, J.⁸

26
- 0343144807
- 2A-adenosine receptor antagonists
- (1997) Eur. J. Med. Chem. , vol.32 , Issue.7 , pp. 709-719
- Müller, C.E.¹ Schobert, U.² Hipp, J.³ Geis, U.⁴ Frobenius, W.⁵ Pawlowski, M.⁶

27
- 0035271592
- 1 Adenosine receptors and their ligands: Overview and recent developments
- (2001) Farmaco , vol.56 , pp. 77-80
- Müller, C.E.¹

28
- 0029657868
- 1 receptor antagonists
- (1996) Bioorg. Med. Chem. , vol.4 , pp. 917-921
- Dooley, M.J.¹ Kono, M.² Suzuki, F.³

29
- 0031752856
- Syntheses of paraxanthine and isoparaxanthine analogues (1,7-and 1,9-Substituted Xanthine Derivatives)
- (1998) Synthesis , pp. 1428-1436
- Müller, C.E.¹ Deters, D.² Dominik, A.³ Pawlowski, M.⁴

30
- 0342275190
- 2A-adenosine receptor antagonists
- (1997) Arch. Pharm. Pharm. Med. Chem. , vol.330 , pp. 181-189
- Müller, C.E.¹ Sauer, R.² Geis, U.³ Frobenius, W.⁴ Talik, P.⁵ Pawlowski, M.⁶

31
- 0029842517
- 3 receptor subtype
- (1996) J. Med. Chem. , vol.39 , pp. 4142-4148
- Kim, Y.-C.¹ Ji, X.-D.² Jacobson, K.A.³

32
- 0022646381
- Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: Potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochormocytoma cells, platelets and fat cells
- (1986) Life Sci. , vol.38 , pp. 797-807
- Ukena, D.¹ Daly, J.W.² Kirk, K.L.³ Jacobson, K.A.⁴

33
- 0028182962
- 2b adenosine receptor in NIH 3T3 fibroblasts
- (1994) Biochem. Pharmacol. , vol.47 , pp. 801-814
- Brackett, L.E.¹ Daly, J.W.²

34
- 84989999966
- Selective removal of the benzyl group from position 3 of purines
- (1968) Isr. J. Chem. , vol.6 , pp. 9-16
- Neimann, Z.¹ Bergmann, F.²

35
- 0003176905
- Eine neue xanthin-synthese
- (1965) Liebigs Ann. Chem. , vol.691 , pp. 142-158
- Goldner, H.¹ Dietz, G.² Carstens, E.³

36
- 0027362627
- Effects of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors
- (1993) J. Med. Chem. , vol.36 , pp. 2639-2644
- Jacobson, K.A.¹ Shi, D.² Gallo-Rodríguez, C.³ Manning, M.⁴ Müller, C.⁵ Daly, J.W.⁶ Neumeyer, J.L.⁷ Kiriasis, L.⁸ Pfleiderer, W.⁹

37
- 0013952979
- Solubility of the xanthines, antipyrine, and several derivatives in syrup vehicles
- (1966) J. Pharm. Sci. , vol.55 , pp. 896
- Paruta, A.N.¹ Sheth, B.B.²

38
- 0021957234
- 2 adenosine receptors
- (1989) J. Med. Chem. , vol.28 , pp. 487-492
- Daly, J.W.¹ Padgett, W.² Shamim, M.T.³ Butts-Lamb, P.⁴ Waters, J.⁵

39
- 0028360136
- 2-adenosine receptor antagonists
- (1994) J. Med. Chem. , vol.37 , pp. 1526-1534
- Grahner, B.¹ Winiwarter, S.² Lanzner, W.³ Müller, C.E.⁴

40
- 0002328607
- Analogues of caffeine and theophylline: Activity as antagonists at adenosine receptors
- Imai, S., Nakazawa, M., Eds.; Elsevier: Amsterdam
- (1991) Role of Adenosine and Adenine Nucleotides in the Biological System , pp. 119-129
- Daly, J.W.¹

41
- 0027189806
- 2-selective adenosine antagonists
- (1993) J. Med. Chem. , vol.36 , pp. 1333-1342
- Jacobson, K.A.¹ Gallo-Rodriguez, C.² Melman, N.³ Fischer, B.⁴ Maillard, M.⁵ Van Bergen, A.⁶ Van Galen, P.J.⁷ Karton, Y.⁸

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