Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)- 1-propargylxanthine) to rat striatal membranes - A new, selective antagonist radioligand for A(2A) adenosine receptors

European Journal of Pharmaceutical Sciences

Volumn 10, Issue 4, 2000, Pages 259-265

  Müller, Christa E ^a   Maurinsh, Juris ^a   Sauer, Roland ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

A(2A) adenosine receptor antagonist; Adenosine receptors; Radioligand; Xanthine; 3H MSX 2

Indexed keywords

2 CHLOROADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR; GUANOSINE TRIPHOSPHATE; MAGNESIUM CHLORIDE; RADIOLIGAND; XANTHINE DERIVATIVE; (H(3))3 (3 HYDROXYPROPYL) 7 METHYL 8 (M METHOXYSTYRYL) 1 PROPARGYLXANTHINE; (H(3))3-(3-HYDROXYPROPYL)-7-METHYL-8-(M-METHOXYSTYRYL)-1-PROPARGYLXANTHINE; ADENOSINE A2A RECEPTOR; STYRENE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; KINETICS; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; RECEPTOR BINDING; ANIMAL; CHEMISTRY; CORPUS STRIATUM; DRUG ANTAGONISM; DRUG POTENTIATION; METABOLISM;

ANIMALS; CORPUS STRIATUM; RATS; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; STYRENES; XANTHINES;

EID: 0033625399     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00064-6     Document Type: Article

References (28)

1. 2A adenosine receptors in rat brain homogenates. Br. J. Pharmacol. 125:1999;27P.
2. 2a adenosine receptor antagonists. Curr. Med. Chem. 2:1995;707-722.
3. 2A adenosine receptors. Life Sci. 59:1996;1373-1388.
4. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
5. 1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 335:1987;59-63.
6. 3H]NECA in rat striatal membranes. Mol. Pharmacol. 29:1986;331-346.
7. Daly J.W., Padgett W. L, Shamim M.T. Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J. Med. Chem. 29:1986;1305-1308.
8. 2A receptors in the caudate-putamen. Neuroreport. 9:1998;1803-1806.
9. 2 receptors in rat brain. J. Pharmacol. Exp. Pharmaceut. 251:1989;888-893.
10. 1 receptor in the rat cortex. Mol. Pharmacol. 39:1991;49-54.
11. 2-adenosine receptors in rabbit striatum. Neurochem. Int. 18:1991;207-213.
12. 1 adenosine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 340:1989;679-683.
13. 3H]-CGS 21680 in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 354:1996;539-541.
14. 1 adenosine receptor with receptor/G protein complexes in rat brain membranes. Mol. Pharmacol. 49:1996;915-926.
15. 2A-selective adenosine receptor antagonists. J. Med. Chem. 40:1997;4396-4405.
16. 2A-selective adenosine receptor antagonists. Bioorg. Med. Chem. 6:1998;707-719.
17. 2A-selective adenosine receptor antagonists: development of water-soluble prodrugs and a new tritiated radioligand. Drug Dev. Res. 45:1998;190-197.
18. Müller C.E., Stein B. Adenosine receptor antagonists: structures and potential therapeutic applications. Curr. Pharm. Design. 2:1996;501-530.
19. 1 adenosine receptor/G protein coupling: identification of a membrane protein that stabilizes the association of the receptor/G protein complex. Mol. Pharmacol. 48:1995;806-817.
20. 2 receptor antagonist, to rat brain membranes. Mol. Pharmacol. 46:1994;817-822.
21. 2a adenosine receptor. Mol. Pharmacol. 48:1995;970-974.
22. Poulsen S.-A., Quinn R.J. Adenosine receptors: new opportunities for future drugs. Bioorg. Med. Chem. 6:1998;619-641.
23. Ralevic V., Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:1998;413-492.
24. 2A receptor antagonists as new agents for the treatment of Parkinson's disease. Trends Pharmacol. Sci. 18:1997;338-344.
25. 2A-selective adenosine receptor antagonists. J. Med. Chem., in press.
26. i adenosine receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 321:1982;84-87.
27. 1 receptor. Eur. J. Pharmacol./Mol. Pharmacol. 290:1995;189-199.
28. 2A adenosine receptor antagonist, to rat striatal membranes. Br. J. Pharmacol. 117:1996;1381-1386.