7-Deazaadenines bearing polar substituents: Structure - Activity relationships of new A1 and A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 43, Issue 24, 2000, Pages 4636-4646

  Hess, S ^c   Muller, C E ^a,b   Frobenius, W ^a   Reith, U ^a,b   Klotz, K N ^a   Eger, K ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIMETHYL 7 (1 METHYLBENZYL) 2 (4' PYRIDYL) 7H PYRROLO[2,3 D]PYRIMIDINE 4 AMINE; 9 (1 METHYLBENZYL) 2 (4' PYRIDYL) 9H PYRIMIDO[4,5 B]INDOLE 4 AMINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ANALYSIS;

ADENINE; ANIMALS; CEREBRAL CORTEX; CHO CELLS; CORPUS STRIATUM; CRICETINAE; HUMANS; INDOLES; PYRIMIDINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 0034736036     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000967d     Document Type: Article

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