Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: A C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin

Angewandte Chemie - International Edition

Volumn 42, Issue 22, 2003, Pages 2515-2517

  Carlomagno, Teresa ^a   Sánchez, Victor M ^a   Blommers, Marcel J J ^b   Griesinger, Christian ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Conformation analysis; Dihedral angle; Natural products; NMR spectroscopy; Tubulin

Indexed keywords

AMINO ACIDS; CARBON; CHEMICAL RELAXATION; NUCLEAR MAGNETIC RESONANCE;

TORSION ANGLES;

KETONES;

CARBON 13; EPOTHILONE A; TUBULIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL BOND; CORRELATION ANALYSIS; DIPOLE; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION TIME;

EID: 0037663864     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200350950     Document Type: Article

References (20)

1. B. Reif, M. Hennig, C. Griesinger, Science 1997, 276, 1230-1233.
2. a) G. S. Harbison, J. Am. Chem. Soc. 1993, 115, 3026-3027;
3. b) T. J. Norwood, Z Magn. Resort. Ser. A 1993,]04, 106.
4. D. Yang, K. H. Gardner, L. E. Kay, Z Biomol. NMR 1998, 11, 213-220.
5. D. Yang, R. Konrat, L. E. Kay, J. Am. Chem. Soc. 1997, 119, 11938-11940.
6. E. Chiarparin, P. Pelupessy, R. Ghose, G. Bodenhausen, J. Am. Chem. Soc. 2000, 122, 1758-1761.
7. E Pelupessy, E. Chiarparin, R. Ghose, G. Bodenhausen, J. Biomol. NMR 1999, 14, 277-280.
8. T. Carlomagno, I. C. Felli, M. Czech, R. Fischer, M. Sprinzl, C. Griesinger, J. Am. Chem. Soc. 1999, 121, 1945-1948.
9. M. J. J. Blommers, W. Stark, C. E. Jones, D. Head, C. E. Owen, W. Jahnke, J. Am. Chem. Soc. 1999, 121, 1949-1953.
10. a) F. Ni, Prog. Nucl. Magn. Reson. Spectrosc. 1994, 26, 517;
11. b) L. Y. Lian, I. L. Barsukov, M. J. Sutcliffe, K. H. Sze, G. C. K. Roberts, Methods Enzymol. 1994, 239, 657-707.
12. a) G. M. Clore, A.M. Gronenborn, J. Magn. Reson. 1982, 48, 402-417;
13. b) G. M. Clore, A. M. Gronenborn, J. Magn. Reson. 1982, 53, 423-442.
14. a) G. Höfle, N. Bedorf, K. Gerth, Chem. Abstr. 1993, 120, 52841;
15. b) G. Höfle, N. Bedorf, H. Steinmetz, D. Schomburg, K. Gerth, H. Reichenbach, Angew. Chem. Int. Ed. Engl. 1996, 35, 1567-1569; Angew. Chem. 1996,]08, 1671-1673.
16. b) G. Höfle, N. Bedorf, H. Steinmetz, D. Schomburg, K. Gerth, H. Reichenbach, Angew. Chem. Int. Ed. Engl. 1996, 35, 1567-1569; Angew. Chem. 1996,]08, 1671-1673.
17. I. C. Felli, C. Richter, C. Griesinger, H. Schwalbe, J. Am. Chem. Soc. 1999, 121, 1956-1957.
18. T. Carlomagno, M. J. J. Blommers, J. Meiler, B. Cuenoud, C. Griesinger, J. Am. Chem. Soc. 2001,]23, 7364-7370.
19. See previous manuscript in this issue: T. Carlomagno, M. J. J. Blommers, J. Meiler, W. Jahnke, T. Schupp, F. Petersen, D. Schinzer, K.-H. Altmann, C. Griesinger, Angew. Chem. 2003, 115, 2511-2515; Angew. Chem. Int. Ed. 2003, 42, 2615-2619.
20. See previous manuscript in this issue: T. Carlomagno, M. J. J. Blommers, J. Meiler, W. Jahnke, T. Schupp, F. Petersen, D. Schinzer, K.-H. Altmann, C. Griesinger, Angew. Chem. 2003, 115, 2511-2515; Angew. Chem. Int. Ed. 2003, 42, 2615-2619.