Generation of inhibitor-sensitive protein tyrosine phosphatases via active-site mutations

Methods

Volumn 42, Issue 3, 2007, Pages 278-288

  Bishop, Anthony C ^a   Zhang, Xin Yu ^a   Lone, Anna Mari ^a  

^a AMHERST COLLEGE   (United States)

Author keywords

Allele specific inhibitors; Hematopoietic PTP (HePTP); Inhibitor sensitization; Protein engineering; Protein tyrosine phosphatases (PTPs); PTP1B; PTPH1; T cell PTP (TCPTP)

Indexed keywords

PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

ARTICLE; DEPHOSPHORYLATION; METHODOLOGY; MUTATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; SENSITIZATION; SIGNAL TRANSDUCTION; SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDOLES; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; PROTEIN-TYROSINE-PHOSPHATASE; SEQUENCE ALIGNMENT;

MAMMALIA;

EID: 34249031540     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2007.02.005     Document Type: Article

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