Crystal structure of PTP-SL/PTPBR7 catalytic domain: Implications for map kinase regulation

Journal of Molecular Biology

Volumn 311, Issue 3, 2001, Pages 557-568

  Szedlacsek, Stefan E ^a   Aricescu, Alexandru R ^a   Fulga, Tudor A ^a   Renault, Louis ^c   Scheidig, Axel J ^b  

^a Institute of Biochemistry   (Romania)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

Author keywords

Crystal structure; MAP kinase regulation; Protein tyrosine phosphatase; PTP SL; PTPBR7

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME REGULATION; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 0035902779     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4890     Document Type: Article

References (56)

1. A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain
2. cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain
3. The mouse Ptprr gene encodes two protein tyrosine phosphatases, PTP-SL and PTPBR7, that display distinct patterns of expression during neural development
4. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase
5. A neuronal protein tyrosine phosphatase induced by nerve growth factor
6. Cloning of PCPTP1-Ce encoding protein tyrosine phosphatase from the rat cerebellum and its restricted expression in Purkinje cells
7. Protein tyrosine phosphatase (PC12, Br7, S1) family: Expression characterization in the adult human and mouse
8. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum
9. Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci
10. Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase)
11. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
12. Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm
13. Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7
14. Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
15. A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
16. The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP
17. Crystal structure of human protein tyrosine phosphatase 1B
18. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate
19. Crystal structure of the tyrosine phosphatase SHP-2
20. Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization
21. The crystal structure of domain 1 of receptor protein-tyrosine phosphatase μ
22. Crystal structure of the tandem phosphatase domains of RPTP LAR
23. Structure and function of the protein tyrosine phosphatases
24. Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B
25. Electrostatic evaluation of the signature motif (H/V)CX5R(S/T) in protein-tyrosine phosphatases
26. Use of an oriented peptide library to determine the optimal substrates of protein kinases
27. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
28. Influence of proline residues on protein conformation
29. Effects on general acid catalysis from mutations of the invariant tryptophan and arginine residues in the protein tyrosine phosphatase from Yersinia
30. The Cys(X)5Arg catalytic motif in phosphoester hydrolysis
31. Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis
32. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
33. Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions
34. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
35. Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase
36. A conserved docking motif in MAP kinases common to substrates, activators and regulators
37. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase
38. Crystal structure of the MAPK phosphatase Pystl catalytic domain and implications for regulated activation
39. Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinase
40. Intramolecular interactions in protein tyrosine phosphatase RPTP mu: Kinetic evidence
41. EZ-FIT: A practical curve-fitting microcomputer program for the analysis of enzyme kinetic data on IBM-PC compatible computers
42. Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
43. ICM - A new method for protein modeling and design. Applications to docking and structure prediction from the distored native conformation
44. AMoRe. A new package for molecular replacement: Application to some difficult cases
45. The CCP4 suite: Programs for protein crystallography
46. wARP - Improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models
47. Crystallography & NMR system - A new software suite for macromolecular structure determination
48. Improved methods for binding protein models in electron density maps and the location of errors in these models
49. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
50. Raster3D version 2.0, a program for photorealistic molecular graphics
51. The protein data bank: A computer-based archival file for macromolecular structures
52. Dictionary of protein secondary structure. Pattern recognition of hydrogen bonded and geometrical features
53. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
54. Bragi: A comprehensive protein modelling program system
55. ESPript: Analysis of multiple sequence alignments in PostScript
56. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures