메뉴 건너뛰기




Volumn 7, Issue 2, 2007, Pages 91-98

Mucosal exposure to antigen: Cause or cure of type 1 diabetes?

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; CD3 ANTIBODY; CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; DNA VACCINE; FOOD ANTIGEN; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; GLUTAMATE DECARBOXYLASE 67; HEAT SHOCK PROTEIN 60; HUMAN INSULIN; INSULIN; INSULIN ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; L SELECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PIG INSULIN; PLACEBO; PROINSULIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; UNINDEXED DRUG;

EID: 34248370977     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-007-0017-3     Document Type: Review
Times cited : (12)

References (67)
  • 1
    • 0035174046 scopus 로고    scopus 로고
    • Collaboration of epithelial cells with organized mucosal lymphoid tissues
    • Neutra MR, Mantis NJ, Kraehenbuhl JP: Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat Immunol 2001, 2:1004-1009.
    • (2001) Nat Immunol , vol.2 , pp. 1004-1009
    • Neutra, M.R.1    Mantis, N.J.2    Kraehenbuhl, J.P.3
  • 2
    • 0039146141 scopus 로고    scopus 로고
    • Design of immune-based interventions in autoimmunity and viral infections - the need for predictive models that integrate time, dose and classes of immune responses
    • discussion 24-30, 45-51
    • von Herrath MG: Design of immune-based interventions in autoimmunity and viral infections - the need for predictive models that integrate time, dose and classes of immune responses. Novartis Found Symp 2001, 239:16-24; discussion 24-30, 45-51.
    • (2001) Novartis Found Symp , vol.239 , pp. 16-24
    • von Herrath, M.G.1
  • 4
    • 2542477129 scopus 로고    scopus 로고
    • Starting at the beginning: New perspectives on the biology of mucosal T cells
    • Cheroutre H: Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu Rev Immunol 2004, 22:217-246.
    • (2004) Annu Rev Immunol , vol.22 , pp. 217-246
    • Cheroutre, H.1
  • 5
    • 33644836224 scopus 로고    scopus 로고
    • Mucosal vaccines: The promise and the challenge
    • Neutra MR, Kozlowski PA: Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 2006, 6:148-158.
    • (2006) Nat Rev Immunol , vol.6 , pp. 148-158
    • Neutra, M.R.1    Kozlowski, P.A.2
  • 7
    • 0033738813 scopus 로고    scopus 로고
    • Antigen-specific therapy for autoimmune disease
    • Harrison LC, Hafler DA: Antigen-specific therapy for autoimmune disease. Curr Opin Immunol 2000, 12:704-711.
    • (2000) Curr Opin Immunol , vol.12 , pp. 704-711
    • Harrison, L.C.1    Hafler, D.A.2
  • 8
    • 0029444727 scopus 로고
    • Autoantigen-induced deletion of peripheral self-reactive T cells
    • Miller JF: Autoantigen-induced deletion of peripheral self-reactive T cells. Int Rev Immunol 1995, 13:107-114.
    • (1995) Int Rev Immunol , vol.13 , pp. 107-114
    • Miller, J.F.1
  • 9
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism?
    • Schwartz RH: Models of T cell anergy: is there a common molecular mechanism? J Exp Med 1996, 184:1-8.
    • (1996) J Exp Med , vol.184 , pp. 1-8
    • Schwartz, R.H.1
  • 11
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, et al.: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155:1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 12
    • 33746338535 scopus 로고    scopus 로고
    • Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    • Roncarolo MG, Gregori S, Battaglia M, et al.: Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006, 212:28-50.
    • (2006) Immunol Rev , vol.212 , pp. 28-50
    • Roncarolo, M.G.1    Gregori, S.2    Battaglia, M.3
  • 13
    • 0034844841 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells
    • Weiner HL: Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect 2001, 3:947-954.
    • (2001) Microbes Infect , vol.3 , pp. 947-954
    • Weiner, H.L.1
  • 14
    • 26444515022 scopus 로고    scopus 로고
    • TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs
    • Bisikirska B, Colgan J, Luban J, et al.: TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest 2005, 115:2904-2913.
    • (2005) J Clin Invest , vol.115 , pp. 2904-2913
    • Bisikirska, B.1    Colgan, J.2    Luban, J.3
  • 16
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    • Nakayama M, Abiru N, Moriyama H, et al.: Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005, 435:220-223.
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3
  • 17
    • 28444486947 scopus 로고    scopus 로고
    • Immunomodulation with human recombinant autoantigens
    • Lernmark A, Agardh CD: Immunomodulation with human recombinant autoantigens. Trends Immunol 2005, 26:608-612.
    • (2005) Trends Immunol , vol.26 , pp. 608-612
    • Lernmark, A.1    Agardh, C.D.2
  • 18
    • 0031726755 scopus 로고    scopus 로고
    • Are there unique autoantigens triggering autoimmune diseases?
    • Bach JF, Koutouzov S, van Endert PM: Are there unique autoantigens triggering autoimmune diseases? Immunol Rev 1998, 164:139-155.
    • (1998) Immunol Rev , vol.164 , pp. 139-155
    • Bach, J.F.1    Koutouzov, S.2    van Endert, P.M.3
  • 19
    • 0031726374 scopus 로고    scopus 로고
    • The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis
    • Tuohy VK, Yu M, Yin L, et al.: The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 1998, 164:93-100.
    • (1998) Immunol Rev , vol.164 , pp. 93-100
    • Tuohy, V.K.1    Yu, M.2    Yin, L.3
  • 20
    • 0035876930 scopus 로고    scopus 로고
    • The frequency of high avidity T cells determines the hierarchy of determinant spreading
    • Tian J, Gregori S, Adorini L, et al.: The frequency of high avidity T cells determines the hierarchy of determinant spreading. J Immunol 2001, 166:7144-7150.
    • (2001) J Immunol , vol.166 , pp. 7144-7150
    • Tian, J.1    Gregori, S.2    Adorini, L.3
  • 21
    • 33644666732 scopus 로고    scopus 로고
    • Antigen processing by autoreactive B cells promotes determinant spreading
    • Dai YD, Carayanniotis G, Sercarz E: Antigen processing by autoreactive B cells promotes determinant spreading. Cell Mol Immunol 2005, 2:169-175.
    • (2005) Cell Mol Immunol , vol.2 , pp. 169-175
    • Dai, Y.D.1    Carayanniotis, G.2    Sercarz, E.3
  • 22
    • 26244468055 scopus 로고    scopus 로고
    • Insulin - a primary autoantigen in type 1 diabetes?
    • Wong FS: Insulin - a primary autoantigen in type 1 diabetes? Trends Mol Med 2005, 11:445-448.
    • (2005) Trends Mol Med , vol.11 , pp. 445-448
    • Wong, F.S.1
  • 23
    • 27844561478 scopus 로고    scopus 로고
    • GAD65- and pro-insulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects
    • Oling V, Marttila J, Ilonen J, et al.: GAD65- and pro-insulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. J Autoimmun 2005, 25:235-243.
    • (2005) J Autoimmun , vol.25 , pp. 235-243
    • Oling, V.1    Marttila, J.2    Ilonen, J.3
  • 24
    • 85047690395 scopus 로고    scopus 로고
    • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    • Arif S, Tree TI, Astill TP, et al.: Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 2004, 113:451-463.
    • (2004) J Clin Invest , vol.113 , pp. 451-463
    • Arif, S.1    Tree, T.I.2    Astill, T.P.3
  • 25
    • 0025837184 scopus 로고
    • Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
    • Zhang ZJ, Davidson L, Eisenbarth G, et al.: Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci U S A 1991, 88:10252-10256.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10252-10256
    • Zhang, Z.J.1    Davidson, L.2    Eisenbarth, G.3
  • 26
    • 0032877655 scopus 로고    scopus 로고
    • Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells
    • Bergerot I, Arreaza GA, Cameron MJ, et al.: Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells. Diabetes 1999, 48:1720-1729.
    • (1999) Diabetes , vol.48 , pp. 1720-1729
    • Bergerot, I.1    Arreaza, G.A.2    Cameron, M.J.3
  • 27
    • 0033566743 scopus 로고    scopus 로고
    • Insulin in oral immune "tolerance": A one-amino acid change in the B chain makes the difference
    • Homann D, Dyrberg T, Petersen J, et al.: Insulin in oral immune "tolerance": a one-amino acid change in the B chain makes the difference. J Immunol 1999, 163:1833-1838.
    • (1999) J Immunol , vol.163 , pp. 1833-1838
    • Homann, D.1    Dyrberg, T.2    Petersen, J.3
  • 28
    • 0030791484 scopus 로고    scopus 로고
    • Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance
    • Ma SW, Zhao DL, Yin ZQ, et al.: Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance. Nat Med 1997, 3:793-796.
    • (1997) Nat Med , vol.3 , pp. 793-796
    • Ma, S.W.1    Zhao, D.L.2    Yin, Z.Q.3
  • 29
    • 1842732158 scopus 로고    scopus 로고
    • Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4
    • Ma S, Huang Y, Yin Z, et al.: Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci U S A 2004, 101:5680-5685.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 5680-5685
    • Ma, S.1    Huang, Y.2    Yin, Z.3
  • 30
    • 4243539805 scopus 로고    scopus 로고
    • A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes
    • Bergerot I, Ploix C, Petersen J, et al.: A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes. Proc Natl Acad Sci U S A 1997, 94:4610-4614.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4610-4614
    • Bergerot, I.1    Ploix, C.2    Petersen, J.3
  • 31
    • 0037221029 scopus 로고    scopus 로고
    • Cholera toxin induces migration of dendritic cells from the subepithelial dome region to T- and B-cell areas of Peyer's patches
    • Shreedhar VK, Kelsall BL, Neutra MR: Cholera toxin induces migration of dendritic cells from the subepithelial dome region to T- and B-cell areas of Peyer's patches. Infect Immun 2003, 71:504-509.
    • (2003) Infect Immun , vol.71 , pp. 504-509
    • Shreedhar, V.K.1    Kelsall, B.L.2    Neutra, M.R.3
  • 32
    • 0032758223 scopus 로고    scopus 로고
    • Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells
    • Ploix C, Bergerot I, Durand A, et al.: Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells. Diabetes 1999, 48:2150-2156.
    • (1999) Diabetes , vol.48 , pp. 2150-2156
    • Ploix, C.1    Bergerot, I.2    Durand, A.3
  • 33
    • 1842837271 scopus 로고    scopus 로고
    • alpha4 integrins and L-selectin differently orchestrate T-cell activity during diabetes prevention following oral administration of CTB-insulin
    • Aspord C, Czerkinsky C, Durand A, et al.: alpha4 integrins and L-selectin differently orchestrate T-cell activity during diabetes prevention following oral administration of CTB-insulin. J Autoimmun 2002, 19:223-232.
    • (2002) J Autoimmun , vol.19 , pp. 223-232
    • Aspord, C.1    Czerkinsky, C.2    Durand, A.3
  • 34
    • 0031839291 scopus 로고    scopus 로고
    • Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes: A protocol effective in NOD mice may exacerbate disease in BB rats
    • Bellmann K, Kolb H, Rastegar S, et al.: Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes: a protocol effective in NOD mice may exacerbate disease in BB rats. Diabetologia 1998, 41:844-847.
    • (1998) Diabetologia , vol.41 , pp. 844-847
    • Bellmann, K.1    Kolb, H.2    Rastegar, S.3
  • 35
    • 0029807595 scopus 로고    scopus 로고
    • Induction of autoimmune diabetes by oral administration of autoantigen
    • Blanas E, Carbone FR, Allison J, et al.: Induction of autoimmune diabetes by oral administration of autoantigen. Science 1996, 274:1707-1709.
    • (1996) Science , vol.274 , pp. 1707-1709
    • Blanas, E.1    Carbone, F.R.2    Allison, J.3
  • 36
    • 0035085647 scopus 로고    scopus 로고
    • Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route
    • Hanninen A, Braakhuis A, Heath WR, et al.: Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route. Diabetes 2001, 50:771-775.
    • (2001) Diabetes , vol.50 , pp. 771-775
    • Hanninen, A.1    Braakhuis, A.2    Heath, W.R.3
  • 37
    • 0036155928 scopus 로고    scopus 로고
    • Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity
    • Hanninen A, Martinez NR, Davey GM, et al.: Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity. J Clin Invest 2002, 109:261-267.
    • (2002) J Clin Invest , vol.109 , pp. 261-267
    • Hanninen, A.1    Martinez, N.R.2    Davey, G.M.3
  • 38
    • 0030060229 scopus 로고    scopus 로고
    • Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells
    • Ke Y, Kapp JA: Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells. J Immunol 1996, 156:916-921.
    • (1996) J Immunol , vol.156 , pp. 916-921
    • Ke, Y.1    Kapp, J.A.2
  • 39
    • 0028954103 scopus 로고
    • CD4+ but not CD8+ T cells are required for the induction of oral tolerance
    • Garside P, Steel M, Liew FY, et al.: CD4+ but not CD8+ T cells are required for the induction of oral tolerance. Int Immunol 1995, 7:501-504.
    • (1995) Int Immunol , vol.7 , pp. 501-504
    • Garside, P.1    Steel, M.2    Liew, F.Y.3
  • 40
    • 0034984007 scopus 로고    scopus 로고
    • Tolerance induction with agonist peptides recognized by autoaggressive lymphocytes is transient: Therapeutic potential for type 1 diabetes is limited and depends on time-point of administration, choice of epitope and adjuvant
    • von Herrath MG, Coon B, Wolfe T: Tolerance induction with agonist peptides recognized by autoaggressive lymphocytes is transient: therapeutic potential for type 1 diabetes is limited and depends on time-point of administration, choice of epitope and adjuvant. J Autoimmun 2001, 16:193-199.
    • (2001) J Autoimmun , vol.16 , pp. 193-199
    • von Herrath, M.G.1    Coon, B.2    Wolfe, T.3
  • 41
    • 0029744298 scopus 로고    scopus 로고
    • Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice
    • von Herrath MG, Dyrberg T, Oldstone MB: Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. J Clin Invest 1996, 98:1324-1331.
    • (1996) J Clin Invest , vol.98 , pp. 1324-1331
    • von Herrath, M.G.1    Dyrberg, T.2    Oldstone, M.B.3
  • 42
    • 0038292006 scopus 로고    scopus 로고
    • The cholera toxin B subunit is a mucosal adjuvant for oral tolerance induction in type 1 diabetes
    • Bregenholt S, Wang M, Wolfe T, et al.: The cholera toxin B subunit is a mucosal adjuvant for oral tolerance induction in type 1 diabetes. Scand J Immunol 2003, 57:432-438.
    • (2003) Scand J Immunol , vol.57 , pp. 432-438
    • Bregenholt, S.1    Wang, M.2    Wolfe, T.3
  • 43
    • 0033213471 scopus 로고    scopus 로고
    • Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway
    • Homann D, Holz A, Bot A, et al.: Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity 1999, 11:463-472.
    • (1999) Immunity , vol.11 , pp. 463-472
    • Homann, D.1    Holz, A.2    Bot, A.3
  • 44
    • 0033914445 scopus 로고    scopus 로고
    • DNA vaccination to treat autoimmune diabetes
    • von Herrath MG, Whitton JL: DNA vaccination to treat autoimmune diabetes. Ann Med 2000, 32:285-292.
    • (2000) Ann Med , vol.32 , pp. 285-292
    • von Herrath, M.G.1    Whitton, J.L.2
  • 45
    • 0038541762 scopus 로고    scopus 로고
    • Intradermal or oral delivery of GAD-encoding genetic vaccines suppresses type 1 diabetes
    • Li AF, Escher A: Intradermal or oral delivery of GAD-encoding genetic vaccines suppresses type 1 diabetes. DNA Cell Biol 2003, 22:227-232.
    • (2003) DNA Cell Biol , vol.22 , pp. 227-232
    • Li, A.F.1    Escher, A.2
  • 46
    • 0036012798 scopus 로고    scopus 로고
    • van den Engel NK, an Haack M, Martin S, et al.: Oral DNA vaccination with a plasmid encoding soluble ICAM-1 modulates cytokine expression profiles in nonobese diabetic mice. J Mol Med 2002, 80:301-308.
    • van den Engel NK, an Haack M, Martin S, et al.: Oral DNA vaccination with a plasmid encoding soluble ICAM-1 modulates cytokine expression profiles in nonobese diabetic mice. J Mol Med 2002, 80:301-308.
  • 47
    • 0030456670 scopus 로고    scopus 로고
    • Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes
    • Harrison LC, Dempsey-Collier M, Kramer DR, et al.: Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes. J Exp Med 1996, 184:2167-2174.
    • (1996) J Exp Med , vol.184 , pp. 2167-2174
    • Harrison, L.C.1    Dempsey-Collier, M.2    Kramer, D.R.3
  • 48
    • 0036408394 scopus 로고    scopus 로고
    • Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice
    • Aspord C, Thivolet C: Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol 2002, 130:204-211.
    • (2002) Clin Exp Immunol , vol.130 , pp. 204-211
    • Aspord, C.1    Thivolet, C.2
  • 49
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B
    • Daniel D, Wegmann DR: Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci U S A 1996, 93:956-960.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 50
    • 33644820235 scopus 로고    scopus 로고
    • Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes
    • Yuki Y, Hara-Yakoyama C, Guadiz AA, et al.: Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes. Biotechnol Bioeng 2005, 92:803-809.
    • (2005) Biotechnol Bioeng , vol.92 , pp. 803-809
    • Yuki, Y.1    Hara-Yakoyama, C.2    Guadiz, A.A.3
  • 51
    • 0036300542 scopus 로고    scopus 로고
    • Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
    • Alleva DG, Gaur A, Jin L, et al.: Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 2002, 51:2126-2134.
    • (2002) Diabetes , vol.51 , pp. 2126-2134
    • Alleva, D.G.1    Gaur, A.2    Jin, L.3
  • 52
    • 0035500757 scopus 로고    scopus 로고
    • Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes
    • Chen W, Bergerot I, Elliott JF, et al.: Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 2001, 167:4926-4935.
    • (2001) J Immunol , vol.167 , pp. 4926-4935
    • Chen, W.1    Bergerot, I.2    Elliott, J.F.3
  • 53
    • 0038814318 scopus 로고    scopus 로고
    • Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
    • Martinez NR, Augstein P, Moustakas AK, et al.: Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide. J Clin Invest 2003, 111:1365-1371.
    • (2003) J Clin Invest , vol.111 , pp. 1365-1371
    • Martinez, N.R.1    Augstein, P.2    Moustakas, A.K.3
  • 54
    • 33645788313 scopus 로고    scopus 로고
    • Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes
    • Every AL, Kramer DR, Mannering SI, et al.: Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes. J Immunol 2006, 176:4608-4615.
    • (2006) J Immunol , vol.176 , pp. 4608-4615
    • Every, A.L.1    Kramer, D.R.2    Mannering, S.I.3
  • 55
    • 16144361909 scopus 로고    scopus 로고
    • Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
    • Tian J, Clare-Salzler M, Herschenfeld A, et al.: Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med 1996, 2:1348-1353.
    • (1996) Nat Med , vol.2 , pp. 1348-1353
    • Tian, J.1    Clare-Salzler, M.2    Herschenfeld, A.3
  • 56
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson D, Togher L, Rodrigo E, et al.: Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest 2006, 116:1371-1381.
    • (2006) J Clin Invest , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3
  • 57
    • 3242754344 scopus 로고    scopus 로고
    • Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3
    • Ostroukhova M, Seguin-Devaux C, Oriss TB, et al.: Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest 2004, 114:28-38.
    • (2004) J Clin Invest , vol.114 , pp. 28-38
    • Ostroukhova, M.1    Seguin-Devaux, C.2    Oriss, T.B.3
  • 58
    • 31844443691 scopus 로고    scopus 로고
    • Natural history of beta-cell function in type 1 diabetes
    • Sherry NA, Tsai EB, Herold KC: Natural history of beta-cell function in type 1 diabetes. Diabetes 2005, 54(suppl 2): S32-S39.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Sherry, N.A.1    Tsai, E.B.2    Herold, K.C.3
  • 59
    • 33744995996 scopus 로고    scopus 로고
    • Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1
    • Sosenko JM, Palmer JP, Greenbaum CJ, et al.: Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2006, 29:643-649.
    • (2006) Diabetes Care , vol.29 , pp. 643-649
    • Sosenko, J.M.1    Palmer, J.P.2    Greenbaum, C.J.3
  • 60
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1
    • Skyler JS, Krischer JP, Wolfsdorf J, et al.: Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial - Type 1. Diabetes Care 2005, 28:1068-1076.
    • (2005) Diabetes Care , vol.28 , pp. 1068-1076
    • Skyler, J.S.1    Krischer, J.P.2    Wolfsdorf, J.3
  • 61
    • 0033846982 scopus 로고    scopus 로고
    • No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group
    • Pozzilli P, Pitocco D, Visalli N, et al.: No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. Diabetologia 2000, 43:1000-1004.
    • (2000) Diabetologia , vol.43 , pp. 1000-1004
    • Pozzilli, P.1    Pitocco, D.2    Visalli, N.3
  • 62
    • 17444437590 scopus 로고    scopus 로고
    • Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial. Diabete Insuline Orale group
    • Chaillous L, Lefevre H, Thivolet C, et al.: Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Diabete Insuline Orale group. Lancet 2000, 356:545-549.
    • (2000) Lancet , vol.356 , pp. 545-549
    • Chaillous, L.1    Lefevre, H.2    Thivolet, C.3
  • 63
    • 4644230843 scopus 로고    scopus 로고
    • Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    • Harrison LC, Honeyman MC, Steele CE, et al.: Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care 2004, 27:2348-2355.
    • (2004) Diabetes Care , vol.27 , pp. 2348-2355
    • Harrison, L.C.1    Honeyman, M.C.2    Steele, C.E.3
  • 64
    • 0027380361 scopus 로고
    • Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Influence of MHC binding affinity
    • Metzler B, Wraith DC: Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity. Int Immunol 1993, 5:1159-1165.
    • (1993) Int Immunol , vol.5 , pp. 1159-1165
    • Metzler, B.1    Wraith, D.C.2
  • 65
    • 0141725404 scopus 로고    scopus 로고
    • Intranasally administered insulin intended for prevention of type 1 diabetes - a safety study in healthy adults
    • Kupila A, Sipila J, Keskinen P, et al.: Intranasally administered insulin intended for prevention of type 1 diabetes - a safety study in healthy adults. Diabetes Metab Res Rev 2003, 19:415-420.
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 415-420
    • Kupila, A.1    Sipila, J.2    Keskinen, P.3
  • 66
    • 0036790542 scopus 로고    scopus 로고
    • Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
    • Liu E, Moriyama H, Abiru N, et al.: Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest 2002, 110:1021-1027.
    • (2002) J Clin Invest , vol.110 , pp. 1021-1027
    • Liu, E.1    Moriyama, H.2    Abiru, N.3
  • 67
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, et al.: Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000, 6:1167-1175.
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.