Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes: A protocol effective in nod mice may exacerbate disease in BB rats

Diabetologia

Volumn 41, Issue 7, 1998, Pages 844-847

  Bellmann, K ^a   Kolb, H ^a,c   Rastegar, S ^b   Jee, P ^b   Scott, F W ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b HEALTH CANADA   (Canada)

^c LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

BB rat; Cytokines; Gut; Immune intervention; Oral insulin; Oral tolerance

Indexed keywords

ADJUVANT; GAMMA INTERFERON; INSULIN; INTERLEUKIN 10;

ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; GENE EXPRESSION REGULATION; IMMUNOSTIMULATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOGENESIS; PRIORITY JOURNAL; RAT; SURVIVAL RATE; TREATMENT INDICATION; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; AGING; ANIMALS; ANTIGENS, BACTERIAL; DIABETES MELLITUS, TYPE 1; ESCHERICHIA COLI; IMMUNITY, MUCOSAL; INSULIN; INTERFERON TYPE II; INTERLEUKIN-10; INTESTINAL MUCOSA; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED BB; RISK FACTORS; TH1 CELLS; TIME FACTORS;

EID: 0031839291     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050997     Document Type: Article

References (9)

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