Intradermal or oral delivery of GAD-encoding genetic vaccines suppresses type 1 diabetes

DNA and Cell Biology

Volumn 22, Issue 4, 2003, Pages 227-232

  Li, Alice F ^a   Escher, Alan ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; CYTOKINE; DNA VACCINE; GLUTAMATE DECARBOXYLASE; PLASMID DNA;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL PRACTICE; DISEASE MODEL; DOSE CALCULATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; TH2 CELL;

ADMINISTRATION, ORAL; ANIMALS; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN G; INJECTIONS, INTRADERMAL; INJECTIONS, INTRAMUSCULAR; INTERFERON TYPE II; MICE; MICE, INBRED NOD; SPLEEN; TREATMENT OUTCOME; VACCINES, DNA;

ANIMALIA;

EID: 0038541762     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454903321908610     Document Type: Article

References (23)

1. BARRY, M.A., and JOHNSTON, S.A. (1997). Biological features of genetic immunization. Vaccine 15, 788-791.
2. BOT A., SMITH D., BOT S., HUGHES A., WOLFE T., WANG L., WOODS C., and VON HERRATH M. (2001). Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. J. Immunol. 167, 2950-2955.
3. BOYLE, J.S., SILVA, A., BTADY, J.L., and LEW, A.M. (1997). DNA immunization: Induction of higher avidity antibody and effect of route on T cell cytotoxicity. Proc. Natl. Acad. Sci. USA 94, 14626-14631.
4. DE ROSE R, TENNENT J., MCWATERS P., CHAPLIN P.J., WOOD P.R., KIMPTON W., CAHILL R., and SCHEERLINCK J.P. (2002). Efficacy of DNA vaccination by different routes of immunization in sheep. Vet. Immunol. Immunopathol. 90, 55-63.
5. FELTQUATE, D.M., HEANEY, S., WEBSTER, R.G., and ROBINSON, H.L. (1997). Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 158, 2278-2284.
6. FILIPPOVA, M., LIU, J., and ESCHER, A. (2001). Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice. DNA Cell Biol. 20, 175-181.
7. GARREN, H., RUIZ, P.J., WATKINS, T.A., FONTOURA, P., NGUYEN, L.T., ESTLINE, E.R., HIRSCHBERG, D.L., and STEINMAN, L. (2001). Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity 15, 15-22.
8. GERDTS, V., BABIUK, L.A., DRUNEN, S.V., HURK, L.D., and GRIEBEL, P.J. (2000). Fetal immunization by a DNA vaccine delivered into the oral cavity. Nat. Med. 6, 929-932.
9. LIU, J., FILIPPOVA, M., FAGOAGA, O., NEHLSEN-CANNARELLA, S., and ESCHER, A. (1999). Intramuscular injection of plasmid DNA encoding intracellular or secreted glutamic acid decarboxylase causes decreased insulitis in the non-obese diabetic mouse. Gen. Ther. Mol. Biol. 3, 197-206.
10. MARON R., MELICAN N.S., and WEINER H.L. (1999). Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes. J. Autoimmun. 12, 251-258.
11. MCCLUSKIE, M.J., BROZOLOT MILLAN, C.L., GRAMZINSKI, R.A., ROBINSON, H.L., SANTORO, J.C., FULLER, J.T., WIDERA, G., HAYNES, J.R., PURCELL, R.H., et al. (1999). Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates. Mol. Med. 5, 287-300.
12. OGRA P.L., FADEN H., and WELLIVER R.C. (2001). Vaccination strategies for mucosal immune responses. Clin. Microbiol. Rev. 14, 430-445.
13. PRUD'HOMME, G.J., CHANG, Y., and LI, X. (2002). Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand. Hum. Gene Ther. 13, 395-406.
14. RAMIYA V.K., SHANG X.Z., WASSERFALL C.H., and MACLAREN N.K. (1997). Effects of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice. Autoimmunity 26, 139-151.
15. RAMSHAW I.A., FORDHAM S.A., BERNARD C.C., MAGUIRE D., COWDEN W.B., and WILLENBORG D.O. (1997). DNA vaccines for the treatment of autoimmune disease. Immunol. Cell Biol. 75, 409-413.
16. REDDY S., STEFANOVIC N., and KARANAM M. (2000). Prevention of autoimmune diabetes by oral administration of syngeneic pancreatic extract to young NOD mice. Pancreas 20, 55-60.
17. REIMANN J., and SCHIRMBECK R. (2000). Modulating specific priming of immune effector functions by DNA-based vaccination strategies. Dev. Biol. (Basel) 104, 15-24.
18. SALMON J.K., ARMSTRONG C.A., and ANSEL J.C. (1994). The skin as an immune organ. West J. Med. 160, 146-152.
19. SHEDLOCK, D.J., and WEINER, D.B. (2000). DNA vaccination: Antigen presentation and the induction of immunity. J. Leukoc. Biol. 68, 793-806.
20. TISCH, R., WANG, B., WEAVER, F.J., LIU, B., BUI, T., ARTHOS, J., and SERREZE, D.V. (2001). Antigen-specific mediated suppression of β cell autoimmunity by plasmid DNA vaccination. J. Immunol. 166, 2122-2132.
21. VON HERRATH, M.G., and WHITON, J.L. (2000). DNA vaccination to treat autoimmune diabetes. Ann. Med. 32, 285-292.
22. WIEST-LADENBURGER, U., FORTNAGEL, A., RICHTER, W., REIMANN, J., and BOEHM, B.O. (1998). DNA vaccination with glutamic acid decarboxylase (GAD) generates a strong humoral immune response in BALB/c, C57BL/6, and in diabetes-prone NOD mice. Horm. Metab. Res. 30, 605-609.
23. WOLFE, T., BOT, A., HUGHES, A., MOHRIE, U., RODRIGO, E., JAUME, J.C., BAEKKESKOV, S., and VON HERRATH, M. (2002). Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: Addition of IL-4 increases safety. Eur. J. Immunol. 32, 113-121.