Oral tolerance: Immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells

Microbes and Infection

Volumn 3, Issue 11, 2001, Pages 947-954

  Weiner, Howard L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Oral tolerance; TGF ; Th3 cell

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN A; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CELL TYPE; CLONAL ANERGY; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SECRETORY CELL; STROKE; TARGET ORGAN; TH1 CELL; TH2 CELL; TH3 CELL;

ANIMALIA; MUS MUSCULUS;

EID: 0034844841     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(01)01456-3     Document Type: Review

References (64)

1. Increased frequency of IL-2 responsive T-cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
2. Autoimmunity, microbial immunity and the immunological homunculus
3. Tolerance, danger, and the extended family
4. Oral tolerance to ovalbumin in mice: Studies of chemically modified and 'biologically filtered' antigen
5. Oral tolerance induced by gut-processed antigen
6. Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T-cells in vivo
7. Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T-cells
8. Evidence for function of Ia molecules on gut epithelial cells in man
9. Oral tolerance to haptens: Intestinal epithelial cells from 2,4-dinitrochlorobenzene-fed mice inhibit hapten-specific T-cell activation in vitro
10. The role of small intestinal antigen-presenting cells in the induction of T-cell reactivity to soluble protein antigens: Association between aberrant presentation in the lamina propria and oral tolerance
11. Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function
12. 2 cells in murine Peyer's patches by oral immunization
13. Functional diversity of helper T lymphocytes
14. In situ immune response in gut associated lymphoid tissue (GALT) following oral antigen in TcR transgenic mice
15. FACS-sorted spleen and Peyer's patch dendritic cells induce different responses in Th0 clones
16. Expanding dendritic cells in vivo enhances the induction of oral tolerance
17. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
18. CTLA4 is required for the induction of high-dose oral tolerance
19. + T-cell-depleted mice
20. B cell-deficient (μMT) mice have lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance
21. Suppressor T-cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of TGF-β following antigen specific triggering
22. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy
23. Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin
24. The regulation of immune responses to dietary protein antigens
25. Immunological response to fed protein antigens in mice: I. Reversal of oral tolerance to ovalbumin by cyclophosphamide
26. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
27. Peripheral deletion of antigen-reactive T-cells in oral tolerance
28. Immunosuppression caused by antigen feeding. I. Evidence for the activation of a feedback suppressor pathway in the spleens of antigen-fed mice
29. Oral administration of the contact sensitizer trinitrochlorobenzene: Initial sensitization and subsequent appearance of a suppressor population
30. Regulation of the primary in vitro response to TNP-polymerized ovalbumin by T suppressor cells induced by ovalbumin feeding
31. Enterically induced immunological tolerance. I. Induction of suppressor T lymphocytes by intragastric administration of soluble proteins
32. Immunological responses to fed protein antigens in mice. II. Oral tolerance for CMI is due to activation of cyclophosphamide-sensitive cells by gut-processed antigen
33. Inhibition of specific immune responses by feeding protein antigens. IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin
34. Stigma variations: Observations on suppressor T-cells and leprosy
35. The distinctive specificity of antigen-specific suppressor T-cells
36. Inhibition of specific immune responses by feeding protein antigens. V. Induction of the tolerant state in the absence of specific suppressor T-cells
37. Oral tolerance: Mechanisms and therapeutic applications
38. + T lymphocytes
39. Epitopes of myelin basic protein that trigger TGF-β release following oral tolerization are distinct from encephalitogenic epitopes and mediate epitope driven bystander suppression
40. Oral tolerance to myelin basic protein induces regulatory TGF-β-secreting T-cells in Peyer's patches of SJL mice
41. Regulatory T-cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
42. + cells mediate active suppression
43. Helper T-cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
44. Immunosuppressive and anti-inflammatory properties of interleukin 10
45. + T-cells: IL-4 and IFN-γ have opposing effects, while TGF-β positively regulates its own production
46. On the mechanisms by which transforming growth factor-beta 2 alters antigen-presenting abilities of macrophages on T-cell activation
47. TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells
48. IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis
49. + T-cells
50. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T-cells by oral administration of myelin in multiple sclerosis patients
51. A critical role for transforming growth factor-β in donor transfusion-induced allograft tolerance
52. Alterations in cytokine production following intraocular injection of soluble protein antigen: Impairment in IFN-gamma and induction of TGF-beta and IL-4 production
53. Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T-cells engineered to express latent TGF-β1
54. + T cells
55. Regulatory T cells in the control of autoimmunity: The essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC-cells and CD4(+)CD8(-) thymocytes
56. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
57. Inactivation of Th1 and Th2 cells by feeding ovalbumin
58. Prevention of lung eosinophilic inflammation by oral tolerance
59. Regulation of antigen-specific IgE, IgG1, and mast cell responses to ingested allergen by mucosal tolerance induction
60. Induction of oral tolerance in TGF-beta 1 null mice
61. Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift
62. Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells