Innate lymphocyte subsets and their immunoregulatory roles in burn injury and sepsis

Journal of Burn Care and Research

Volumn 28, Issue 3, 2007, Pages 365-379

  Schneider, David F ^a   Glenn, Cavin H ^a,b   Faunce, Douglas E ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b Mount Sinai Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; KERATINOCYTE GROWTH FACTOR; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

BURN; CELLULAR IMMUNITY; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOPATHOLOGY; IMMUNOREGULATION; INNATE IMMUNITY; LYMPHOCYTE; MACROPHAGE; MEDICAL RESEARCH; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; REGULATORY T LYMPHOCYTE; REVIEW; SEPSIS; T LYMPHOCYTE; UPREGULATION;

BRAIN INJURIES; HUMANS; IMMUNITY, NATURAL; KILLER CELLS, NATURAL; LYMPHOCYTES; SEPSIS; T-LYMPHOCYTES, REGULATORY;

EID: 34248328333     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0B013E318053D40B     Document Type: Review

References (99)

1. Moretta A, Bottino C, Mingari MC, et al. What is a natural killer cell? Nat Immunol 2002;3:6-8.
2. Tosi MF. Innate immune responses to infection. J Allergy Clin Immunol 2005;116:241-49.
3. Yadavalli GK, Auletta JJ, Gould MP, et al. Deactivation of the innate cellular response following endotoxic and surgical injury. Exp Mol Pathol 2001;71:209-21.
4. Keel M. Endotoxin tolerance after severe injury and its regulatory mechanisms. J Trauma 1996;41:430-7.
5. Joshi P, Hauser CJ, Jones Q, et al. Mechanism of supression of natural killer cell activity in trauma patients. Res Comm Mol Pathol 1998;101:241-8.
6. Livingston DH. Depressed interferon gamma production and monocyte HLA-DR expression after severe injury. Arch Surg 1988;123:1309-12.
7. Blazar BA, Rodrick ML, O'Mahony JB, et al. Suppression of natural killer-cell function in humans following thermal and traumatic injury. J Clin Immunol 1986;6:36.
8. Ditschkowski M, Kreuzfelder E, Majetschak M, et al. Reduced B cell HLA-DR expression and natural killer cell counts in patients prone to sepsis after injury. Eur J Surg 1999;165:1129-33.
9. Hauser CJ, Joshi P, Jones Q, et al. Suppression of natural killer cell activity in patients with fracture/soft tissue injury. Arch Surg 1997;132:1326-30.
10. Jobin N, Garrel D, Bernier J. Increased serum-soluble interleukin-2 receptor in burn patients: characterization and effects on the immune system. Human Immunol 2000;61:233-46.
11. Bower RH, Cerra FB, Bershadsky B, et al. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patiens: Results of a multicenter, prospective, randomized clinical trial. Crit Care Med 1995;23:436-49.
12. Gottschlich WM, Warden GD. Vitamin supplementation in the patient with burns. J Burn Care Rehabil 1990;11:275-9.
13. Weimann A, Bastian L, Bischoff WE, et al. Influence of arginine, omega-3 fatty acids and nucleotide-supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma. Nutrition 1998;14:165-72.
14. Pratt VC, Tredget EE, Clandinin MT, et al. Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans. Crit Care Med 2002;30:1753-61.
15. O'Suilleabhain C, O'Sullivan ST, Kelly JL, et al. Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury. Surgery 1996;120:290-6.
16. Ami K, Kinoshita M, Yamauchi A, et al. IFN-gamma production from liver mononuclear cells of mice in burn injury as well as in postburn bacterial infection models and the therapeutic effect of IL-18. J Immunol 2002;169:4437-42.
17. Medzhitov R. Innate immune recognition and control of adaptive immune responses. Semin Immunol 1998;10:351-53.
18. Carson WE, Haixin Y, Dierksheide J, et al. A fatal cytokineinduced systemic inflammatory response reveals a critical role for NK cells. J Immunol 1999;162:4943-51.
19. Moore KW, O'Garra A, de Waal MR, et al. Interleukin-10. Ann Rev Immunol 1993;11:165-90.
20. Scott MJ, Hoth JJ, Stagner MK, et al. CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol 2004;137:469-77.
21. Godshall CJ, Scott MJ, Burch PT, et al. Natural killer cells participate in bacterial clearance during septic peritonitis through interactions with macrophages. Shock 2003;19:144-9.
22. Scott MJ, Hoth JJ, Gardner SA, et al. Natural killer cell activation primes macrophages to clear bacterial infection. Am Surg 2003;69:679-87.
23. Goldmann O, Chhatwal GS, Medina E. Contribution of natural killer cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice. J Infect Dis 2005;191:1280-6.
24. Badgwell B, Parihar R, Magro C, et al. Natural killer cells contribute to the lethality of a murine model of Escherichia coli infection. Surgery 2002;132:205-12.
25. Sherwood ER, Lin CY, Tao W, et al. Beta-2 Microglubulin knockout mice are resistant to lethal intraabdmoninal sepsis. Am J Respir Crit Care Med 2003;167:1641-9.
26. Emoto M, Miyamoto M, Yoshizawa I, et al. Critical role of NK cells rather than V alpha 14(+)NKT cells in lipopolysaccharideinduced lethal shock in mice. J Immunol 2002;169:1426-32.
27. Raeder RH, Barker-Merrill L, Lester T, et al. A pivotoal role for interferon-gamma in protection against group A streptococcal skin infection. J Infect Dis 2000;181:639-45.
28. Heremans H, Van Damme J, Dillen C, et al. Interferongamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice. J Exp Med 1990;171:1853-69.
29. Seki S, Osada S, Ono S, et al. Role of liver NK cells and peritoneal macrophages in interferon-gamma and interleukin-10 production in experimental bacterial peritonitis in mice. Infect Immun 1998;66:5286-94.
30. Dieli FD, Sireci G, Russo D, et al. Resistance of natural killer T cell-deficient mice to systemic Shwartzman Reaction. J Exp Med 2000;192:1645-51.
31. Hirsh M, Kaplan V, Dyugovskaya L, et al. Response of lung NK1.1-positive natural killer cells to experimental sepsis in mice. Shock 2004;22:40-5.
32. Joyce S. CD1d and natural T cells: how their properties jumpstart the immune system. Cell Mol Life Sci 2001;58:442-69.
33. + T lymphocytes. Science 1995;268:863-5.
34. - T cells in mice and humans. J Exp Med 1994;180:1097-106.
35. Godfrey DI, MacDonald R, Kronenberg M, et al. NKT cells: what's in a name? Nat Rev 2004;4:231-7.
36. Zhou D, Mattner J, Cantu C, et al. Lysosomal glycoshingolipid recognition by NKT cells. Science 2004;306:1786-9.
37. Godfrey DI, Konenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 2004;114:1379-88.
38. Parekh VV. iNKT-cell responses to glycolipids. Crit Rev Immunol 2005;25:183-213.
39. Sonoda KH, Faunce DE, Taniguchi M, et al. NKT cell-derived IL-10 is essential for the differentiation of antigenspecific T regulatory cells in systemic tolerance. J Immunol 2001;166:42-50.
40. Taniguchi M, Seino K, Nakayama T. The NKT cell system: bridging innate and acquired immunity. Nature Immunol 2003;4:1164-5.
41. Biron CA. NK cells and NKT cells in innate defense against viral infections. Curr Opinion Immunol 2001;13:458-64.
42. Toshihiko K, Takeda K, Mandiratta SK, et al. Critical Role of NK1+ T cells in IL-12 induced immune responses in vivo. J Immunol 1998;160:16-19.
43. Faunce DE, Gamelli RL, Kovacs EJ. A role for CD1d-NKT cells in injury-associated T cell suppression. J Leukoc Biol 2003;73:747-55.
44. Palmer JL, Tulley JM, Kovacs EJ, et al. Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells. J Immunol 2006;177:92-9.
45. American Burn Association. National Burn Repository: 2002 Report. Chicago: American Burn Association; 2002.
46. Wu D, Xing G, Poles MA, et al. Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci USA 2005;102:1351-6.
47. Apostolou I, Takahama Y, Belmant C, et al. Murine natural killer T (NKT) cells contribute to the granulomatous reaction caused by mycobacterial cell walls. Proc Natl Adad Sci USA 1999;96:5141-6.
48. Kawakami K, Kinjo Y, Yara S, et al. Activation of Valpha14+ natural killer T cells by alpha-glactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans. Infect Immun 2001;69:213-20.
49. Skold M, Behar SM. Role of CD1d-restricted NKT cells in microbial immunity. Infect Immun 2003;71:5447-55.
50. Ozmen L. Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction. J Exp Med 1994;180:907-15.
51. Dieli F, Sireci G, Russo D, et al. Resistance of Natural Killer T cell-deficient mice to systemic Shwartzman reaction. J Exp Med 2000;192:1645-51.
52. Nieuwenhuis EE, Matsumoto T, Exley MA, et al. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med 2002;8:588-93.
53. Kim CH. Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Va24+VB11+ NKT cell subsets with distinct cytokine-producing capacity. Blood 2002;100:11-6.
54. Faunce DE, Sonoda KH, Stein-Streilein J. MIP-2 recruits NKT cells to the spleen during tolerance induction. J Immunol 2001;166:313-21.
55. Kawakami K, Yamamoto N, Kinjo Y, et al. Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection. Eur J Immunol 2003;33:3322-30.
56. Carding RR, Egan PJ. γδ T cells: functional plasticity and heterogeneity. Nat Immunol 2002;2:336-45.
57. Hayday A, Tigelaar R. Immunoregulation in tissues by γδ T cells. Nat Immunol 2003;3:233-42.
58. Buckowski JF, Morita CT, Brenner MB. Human γδ T cells recongnize alkylamines derived from microbes, edible plants, tea: Implications for innate immunity. Immunity 1999;11:57-65.
59. Crowley MP, Fahrer AM, Baumgarth N, et al. A population of murine γδ T cells that recognize an inducible MHC class Ib molecule. Science 2000;287:314-6.
60. Jameson J, Ugarte K, Chen N, et al. A role for skin γδ T cells in wound repair. Science 2002;296:747-9.
61. Sharp LL, Jameson JM, Cauvi G, et al. Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1. Nat Immunol 2005;6:79.
62. Schwacha MG, Ayala A, Chaudry IH. Insights into the role of gamma delta T lymphocytes in the immunopathogenic response to thermal injury. J Leukoc Biol 2000;67:644-50.
63. Schwacha MG. Macrophages and post-burn immune dysfunction. Burns 2003;29:14.
64. Balazs T, Michelle A, Daniel T, et al. The role of γδ T cells in the regulation of neutrophil-mediated tissue damage after thermal injury. J Leukoc Biol 2004;76:552.
65. Lahn M, Kalataradi H, Mittlestadt P, et al. Early preferential stimulation of γδ T cells by TNF-α. J Immunol 1998;160:5230.
66. Yeh FL, Lin WL, Shen HD, et al. Changes in serum tumor necrosis factor-α in burned patients. Burns 1997;23:10.
67. Spies M, Chappell VL, Dasu MR, et al. Role for TNF-α in gut mucosal changes after severe burn. Am J Physiol 2002;283:G703-8.
68. Wu X, Woodside KJ, Song J, et al. Burn-induced gut mucosal homeostasis in TCR delta receptor deficient mice. Shock 2004;21:52-7.
69. Moore TA, Moore BB, Newstead MW, et al. γδ T cells are critical for the survival and early proinflammatory cytokine gene expression during murine Klebsiella pneumonia. J Immunol 2000;165:2642-50.
70. O'Brien R, Yin X, Huber SA, et al. Depletion of gamma delta T cell subsets increases host resistance to a bacterial infection. J Immunol 2000;165:6473-9.
71. Belles C, Kuhl AK, Donoghue AJ, et al. Bias in the gamma delta T cell response to Listeria monocytogenes. V delta 6.3+ cells are a major component of the gamma delta T cell response to Listeria monocytogenes. J Immunol 1996;156:4280-9.
72. Ladel CH, Blum C, Kaufmann SH. Control of Natural Killer cell-mediated innate resistance against the intracellular pathogen Listeria monocytogenes by γδ T lymphocytes. Infection and Immunity 1996;64:1744-9.
73. Li B, Rossman MD, Imir T, et al. Disease-specific changes in γδ T cells repertoire and function in patients with pulmonary tuberculosis. J Immunol 1996;157:4222-9.
74. Li B, Bassiri H, Rossman MD, et al. Involvement of Fas/Fas-ligand pathway in activation induced cell death of mycobacteria reactive human γδ T cells: a mechanism for the loss of γδ T cells in patients with pulmonary turberculosis. J Immunol 1998;161:1558-67.
75. Hirsh M, Hashiguchi N, Chen Y, et al. LPS-stimualted neutrophils facilitate gamma delta T cell-mediated killing. Eur J Immunol 2006;36:712-21.
76. Hirsh M, Dyugovskaya L, Kaplan V, et al. Response of lung γδ T cells to experimental sepsis in mice. Immunology 2004;112:153-60.
77. Matsushima A, Ogura H, Fujita K, et al. Early activation of γδ T lymphocytes in patients with severe systemic inflammatory response syndrome. Shock 2004;22:11-5.
78. Venet F, Bohe J, Debard A, et al. Both the percentage of γδ T lymphocytes and CD3 expression are reduced during septic shock. Critical Care Medicine 2005;33:2836-40.
79. Chung C, Xu YX, Wang W, et al. Is Fas ligand endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? Arch Surg 1998;133:1213-20.
80. Chung C, Watkins L, Funches A, et al. Deficiency of γδ T lymphocytes contributes to mortality and immunosuppression in sepsis. Am J Physiol Reg Integr Comp Physiol 2006;291:R1343.
81. Mills KH. Regulatory T cells: friend or foe in immunity to infection. Nat Rev Immunol 2004;4:841-55.
82. Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). J Immunol 1995;155:1151-61.
83. LaCava A, Van Kaer L, Fu-Dong-Shi. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol 2006;27:322-7.
84. Furtado GC, Curotto de Lafaille MA, Kutchukhidze N, et al. Interleukin 2 signaling is required for CD4+ regulatory T cell function. J Exp Med 2002;196:851-7.
85. Shevach EM. CD4+CD25+ suppressor T cells: more questions than answers. Nature Reviews Immunology 2002;2:557-68.
86. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Ann Rev Immunol 2004;22:531-62.
87. Jiang S, Game DS, Davies D, et al. Activated CD1d-restricted natural killer T cells secrete IL-2: innate help for CD4+CD25+ regulatory T cells. Eur J Immunol 2005;4:1193-200.
88. Takeshi A, Takahashi T, Kunisato A, et al. Human CD4+CD25+ regulatory T cells suppress NKT cell functions. Cancer Res 2003;63:4516-20.
89. + regulatory T cells in patients with multiple sclerosis. J Exp Med 2004;199:971-9.
90. Murphy TJ, Choileain NN, Zang Y, et al. CD4+CD25+ regulatory T cells control innate immune reactivity after injury. J Immunol 2005;174:2957-63.
91. Choileain NN, MacConmara M, Zang Y, et al. Enhanced regulatory T cell activity is an element of the hot response to injury. J Immunol 2005;176:225-36.
92. MacConmara M, Maung AA, Fujimi S, et al. Increased CD4+CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity. Ann Surg 2006;244:514-23.
93. Caramalho I, Lopes-Carvalho T, Ostler D, et al. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003;197:403-11.
94. Heuer JG, Zhang T, Zhao J, et al. Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis. J Immunol 2005;176:7141-6.
95. Scumpia PO, Delano MJ, Kelly KM, et al. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol 2006;177:7943-9.
96. Kullberg MC, Jankovic D, Gorelick PL, et al. Bacteriatriggered CD4+ T regulatory cells suppress Heliobacter hepaticus-induced colitis. J Exp Med 2002;197:111-9.
97. Maloy KJ, Salaun L, Cahill R, et al. CD4+CD25+ Treg cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 2003;197:111-9.
98. Monneret G, Debard A, Venet F, et al. CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 2003;31:2068-71.
99. Venet F, Pachot A, Debard A, et al. Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25- lymphocytes. Crit Care Med 2004;32:2329-31.